This episode explores how Urban Indian Organizations imbued American Indian and Alaska Native cultural heritage and values into their infection control programs during the COVID-19 pandemic. Cultural competency is an essential part of training for healthcare professionals in UIOs and that extends to the world of infection control. By placing infection control principles into a cultural context, UIOs are better equipped to serve both patients and health care professionals in their field. Additionally, we will examine the unique role UIOs play in serving the diverse indigenous diaspora in the United States.