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What if you could edit a drug molecule the way you edit a document? Not rebuild it from scratch, just go in, find what needs changing, and fix it.

That’s exactly what skeleton editing does. And it might be one of the most underreported breakthroughs in modern chemistry.

In this episode I dig into what skeleton editing actually is, why it matters for drug discovery, and how it connects to the other tools reshaping medicine right now: CRISPR, AlphaFold, and Isomorphic Labs.

Together these technologies are attacking the biggest bottleneck in medicine, iteration speed, from every angle at once. For the first time we have tools working at every level of biology simultaneously.

This is what engineering medicine looks like.

Links to articles sited in the episode and CRISPR Casgevy success cases:

Science Magazine — Skeleton Editing:

PhRMA — Research & Development:

Patheon — Drug Development Phases:

The Applied Science — Biotech Product Dev:

AlphaFold Protein Database

Isomorphic Labs - Isomorphic Labs website

CRISPR Casgvey success case in Uganda

Another CRISPR world treatment case at Children’s Hospital in Philadelphia.

Why I swapped my mattress and bed for the floor—and how it’s changed my back (and sleep!)

Book Recommendation - Back Mechanic: The Secrets to a Healthy Spine Your Doctor Isn't Telling You.

Executive Producers: Sol & Ben

Ever wondered how a tiny microSD can store so much data in a tiny space? Well, thanks to quantum tunneling and clever math. In this episode we explain how important it has been for the 21st century innovations.

Executive Producers: Sol & Ben

For collaborations and episode suggestions: [email protected]

In this episode, I discuss decision-making, focusing on mental models and heuristics. I share personal experiences from product management, exploring tools like opportunity cost, first principles thinking, and cognitive biases. I suggest expanding mental models, challenging biases, and using techniques like the Feynman Method and 80/20 Rule and more to improve our decision making and communication.

Timestamps and key moments:

00:00:00 - Intro.

00:01:06 - Intro to Mental models and there usefulness to breaking down complex ideas for better decision making.

00:03:09 - Drawbacks on over relying on Mental models.

00:04:04 - Intro to heuristics and how they influence our decisions like the availability heuristics, anchoring heuristics and more.

00:06:35 - Benefits and drawbacks of heuristics in making decisions.

00:07:35 - Exploring ways to use Mental models and heuristics for better decision making.

00:10:55 - More mental models like the Feynman Technique, Inversion, Occam’s razor, etc can help you in making better decisions.

00:18:10 - Intro to Framing, Baader-Meinhof Phenomenon, and confirmation bais.

00:18:29 - Exploring Framing and how information is presented influences our decisions.

00:19:48 - Exploring confirmation bias and the Baader-Meinhof Phenomenon.

00:21:27 - Closing remarks concluding everything we have discussed in the episode. It also discusses how these models make us better decision markers and better communicators.

00:24:51 - FS blog article recommendation. It covers all the mental models I’ve mentioned in this episode and more from the fields of economics, physics, biology and more.

00:25:14 - Book recommendation: Thinking Fast, and Slow by Daniel Kahneman on the psychology of decision making.

00:25:56 - Outro :)

Links:

FS blog on mental models

Earth day article

Thinking Fast, And Slow (Online read)

Production Credits

Executive Producer, Script, Research: Sol & Ben

Got topics you want us to look into? Want to feature on our podcast? Got any Book recommendations?

Send us an email at [email protected]

In today's episode, we dive into Uganda's bold energy plans that plans to have at least one nuclear energy plan by 2031 and generating over $2 billion from their oil reserves by 2040.

We look at the whether Uganda's high risk appetite outweigh the potential risks that could put not just the country's economy in shambles but millions of lives at stake with pollution and environmental concerns.

Can Uganda realistically pull off a nuclear energy power plant 7 years from now? Join the conversation.

Timestamps and Key moments

00:00:00 - Brief intro by Sol and Ben. Detailed description by Sol.

00:02:25 - Introduction to nuclear energy by Ben. It's history and the scientists behind the invention.

00:04:07 - Nuclear fission - the process of splitting atoms to produce energy out of mass.

00:05:36 - First Nuclear fission real world use that changed the future of nuclear fission reactors forever.

00:07:00 - Nuclear energy safety measures.

00:09:00 - Nuclear fusion and why it is future of cleaner energy. Fusion is the process of combining light atoms, typically hydrogen, to form a heavier element like helium.

00:12:10 - Uganda's nuclear power plant plan and its economic impact.

00:22:15 - Exploring Uganda's alternative energy sources i.e hydroelectricity, solar and geothermal.

00:29:35 - Exploring Uganda's oil mining plan.

00:37:16 - Conclusion.

00:38:30 - Book recommendation segment

Links

Our Apple Music Playlist

Our Spotify Playlist

Rest: Why You Get More Done When You Work Less

Production Credits

Executive Producer, Script, Research: Sol & Ben

Got topics you want us to look into? Want to feature on our podcast? Book recommendations?

Send us an email at [email protected]

Infrared dialogue introduces you to wide range of perspectives from arts to engineering to music and more. Join us as we explore.