Innovation Overground

Humanity went 200,000 years without genetically modifying a baby. Then some knucklehead went ahead and did it in 2018. Tyler perp-walks the baby-modifying science hooligans to the Overground firing squad. Joe adds how the original CRISPR patents are made commercially available by their respective institutions, as well as the therapeutic applications of the UNMC-co-invented EASI-CRISPR.  

Featured Technology: https://www.broadinstitute.org/partnerships/office-strategic-alliances-and-partnering/information-about-licensing-crispr-genome-edi ; https://www.unemed.com/product/crispr-cas9-editing-tool 

Hosts: Charlie Litton (@charlielitton); Tyler Scherr (@dare2scherr); Joe Runge (@EntreprenurialW) 

Sponsor:  UNeMed (https://www.unemed.com); @UNeMed 

Music: Countdown to Myocardial Infarction, by Peter Gresser. Used with permission. http://sonofactori.com/

Tyler’s got the dots... let’s get to connecting them! He leads the Overground crew on a guided tour of the origin of psychedelic drugs and the emerging science about how they may offer new hope for people with debilitating mental illness.  

Featured Technology: https://compasspathways.com/research-clinical-trials/; https://clinicaltrials.gov/ct2/show/NCT03775200?term=psilocybin&cond=treatment+resistant+depression&rank=1  

Hosts: Charlie Litton (@charlielitton); Tyler Scherr (@dare2scherr); Joe Runge (@EntreprenurialW) 

Sponsor:  UNeMed (https://www.unemed.com); @UNeMed 

Music: Countdown to Myocardial Infarction, by Peter Gresser. Used with permission. http://sonofactori.com/

Joe’s calling it: The U.S. silicon solar panel party is over. Done. Last one out please turn off the lights... ‘cause we’re all heading to the Overground after-party! Join the Overground as they discuss how to “level-up" current solar technology and the truly wide-open future of electricity generation, which may or may not include a giant Acme-style magnifying glass hanging off the moon.  

Featured Technology: http://jhu.technologypublisher.com/techcase/C14576

Hosts: Charlie Litton (@charlielitton); Tyler Scherr (@dare2scherr); Joe Runge (@EntreprenurialW) 

Sponsor:  UNeMed (https://www.unemed.com); @UNeMed 

Music: Countdown to Myocardial Infarction, by Peter Gresser. Used with permission. http://sonofactori.com/

Did you know that you’re living in the biotechnology century? Decades of innovation have made DNA sequencing cheap and easy, littering the world with piles of genetic code. Tyler guides the Overground through the innovative software applications that turns piles of sequence data into clinically relevant information. Join the crew they discuss how bioinformatics detects diseases, keeps you healthy and why we have a spleen. 

Featured Technology: https://www.unemed.com/product/smzl-specific-biomarkers; https://www.unemed.com/product/cancer-classification-algorithm; https://webapps.fhcrc.org/sites/public/bdir/technology/technologies/detail/colon-cancer-biomarkers-14-033  

Hosts: Charlie Litton (@charlielitton); Tyler Scherr (@dare2scherr); Joe Runge (@EntreprenurialW) 

Sponsor:  UNeMed (https://www.unemed.com); @UNeMed 

Music: Countdown to Myocardial Infarction, by Peter Gresser. Used with permission. http://sonofactori.com/

Set your minds for blown as Joe leads the Overground through the latest on quantum computing and something involving a cat in a meow-proof box. Also, if no one listens to a quantum podcast, then the podcast both exists and doesn’t exist at the same time...unless there’s a dead cat in a box? You should probably just listen to this one for yourself. 

Featured Technologies: https://techlaunch.arizona.edu/news/tech-blog-college-engineering-faculty-advance-world-quantum-computing; https://umdrightnow.umd.edu/news/new-quantum-computer-module-sets-stage-general-purpose-quantum-computers; https://www.youtube.com/watch?v=OWJCfOvochA

Hosts: Charlie Litton (@charlielitton); Tyler Scherr (@dare2scherr); Joe Runge (@HJRunge) 

Sponsor:  UNeMed (https://www.unemed.com); @UNeMed 

Music: Countdown to Myocardial Infarction, by Peter Gresser. Used with permission. http://sonofactori.com/

Are your lazy houseplants judging you? Put them to work! When your ficus tree turns purple, you’ll know you have a deadly radon leak. The University of Tennessee is working on plants capable of sensing changes in the environment and alerting their human caretakers. And it’s Tyler’s favorite way to beat seasonal affective disorder: life-affirming, indoor greenery!  

Featured Technology: http://utrf.technologypublisher.com/technology/13001; https://ag.tennessee.edu/news/Pages/NR-2018-07-SciencePerspectiveHouseplants.aspx  

Hosts: Charlie Litton (@charlielitton); Tyler Scherr (@dare2scherr); Joe Runge (@HJRunge) 

Sponsor:  UNeMed (https://www.unemed.com); @UNeMed 

Music: Countdown to Myocardial Infarction, by Peter Gresser. Used with permission. http://sonofactori.com/

Live! From the llama pit at the Wylie Park Zoo in beautiful Aberdeen, South Dakota, (in spirit) the Overground crew explains why the flu vaccine only works 30% of the time. Tyler explains how sneaky the flu really is, how a new invention from the University of South Dakota may make a better vaccine and why llama’s don’t get the flu, but if they do...

Featured Technology: https://www.usd.edu/-/media/files/research/business-and-industry/researchinfluenzaafluvaccine.ashx?la=en; http://science.sciencemag.org/content/362/6414/598  

Hosts: Charlie Litton (@charlielitton); Tyler Scherr (@dare2scherr); Joe Runge (@HJRunge) 

Sponsor:  UNeMed (https://www.unemed.com); @UNeMed 

Music: Countdown to Myocardial Infarction, by Peter Gresser. Used with permission. http://sonofactori.com/

Happy birthday Bayh-Dole! The Overground crew celebrates the law that created university technology transfer and closes out 2018 with hard hitting questions: Why are we so fat? Can technology change our daily behavior? When do the things we do become our legacies? Is that robot inside you doing surgery? Thank you to everyone who listened in Overground’s freshman year. We left our yearbook in our locker so you’ll just have to come find us again next year.  

Featured Technology: https://www.unemed.com/product/a-wrist-a-trac ; https://prommuneinc.com/ ; https://www.virtualincision.com/ 

Hosts: Charlie Litton (@charlielitton); Tyler Scherr (@dare2scherr); Joe Runge (@HJRunge) 

Sponsor:  UNeMed (https://www.unemed.com); @UNeMed 

Music: Countdown to Myocardial Infarction, by Peter Gresser. Used with permission. http://sonofactori.com/

The obvious common thread between batteries and English muffins is, of course, contact lenses. An unusually high-energy Joe unravels that mystery after whining about battery chemistry and how it basically remains unchanged from Thomas Edison's ideas more than 100 years ago. The crew discusses Innovative power storage technologies await us in the form of…supercapacitors!

Featured Technology: http://www.bris.ac.uk/news/2018/february/supercapacitor.html; https://www.nasa.gov/ames-partnerships/technology/technology-opportunity-metal-oxide-vertical-graphene-hybrid-supercapacitors

Hosts: Charlie Litton (@charlielitton); Tyler Scherr (@dare2scherr); Joe Runge (@HJRunge)

Sponsor:  UNeMed (https://www.unemed.com); @UNeMed

Music: Countdown to Myocardial Infarction, by Peter Gresser. Used with permission. http://sonofactori.com/

We live in a brief moment where bacterial infections do not routinely kill people...which is coming to a close. Each day, the medicines we use to treat bacterial infection are getting a little less effective and there are not enough new drugs coming to market. The Overground crew discuss a technology that uses viruses to kill bacterial infections, and the hard choices that confront new technologies throughout the world.

Featured Technology: Phage Lysins https://www.rockefeller.edu/technology-transfer/technologies/infectiousdiseases/fischettilysins/; future technologies to come from UC San Diego Center for Innovative Phage Applications and Therapeutics https://medschool.ucsd.edu/som/medicine/divisions/idgph/research/center-innovative-phage-applications-and-therapeutics/Pages/default.aspx 

Hosts: Charlie Litton (@charlielitton); Tyler Scherr (@dare2scherr); Joe Runge (@HJRunge)

Sponsor:  UNeMed (https://www.unemed.com); @UNeMed

Music: Countdown to Myocardial Infarction, by Peter Gresser. Used with permission. http://sonofactori.com/