In this episode, we dive deep into major gastrointestinal and hepatic disorders, exploring their pathophysiology, assessment findings, and nursing management. We begin with Peptic Ulcer Disease (PUD)—unpacking its causes like H. pylori infection and NSAID use, key differences between gastric and duodenal ulcers, and treatment options including PPIs and antibiotic therapy. We then move into viral hepatitis (A, B, and C), examining routes of transmission, clinical stages such as the icteric phase, and critical prevention measures like vaccination and education. Finally, we discuss liver dysfunction and cancer, focusing on hallmark complications—bleeding tendencies, edema, and metabolic disturbances—and the distinction between primary hepatocellular carcinoma and metastatic liver disease. This episode ties together the essential nursing priorities needed to care for patients with complex gastrointestinal and hepatic conditions.