Your Wise Self with Sara

Insulin Resistance in Perimenopause with Aaron McDonough, Pharm D


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If you're in midlife and feeling frustrated with unexplained weight gain, energy crashes, brain fog, or confusing lab results, you're not alone. In this episode, we're diving deep into insulin resistance in perimenopause: what it is, why it happens, and most importantly, what actually helps.

I'm joined by Aaron McDonough, PharmD, a functional health pharmacist and owner of Towncrest Pharmacy. Aaron specializes in personalized care, including lab-informed supplementation and compounded hormones, and he has a gift for explaining complex physiology in a way that feels empowering instead of overwhelming.

In this conversation, we explore:
 • What insulin resistance really means in plain language
 • How hormonal shifts in perimenopause contribute to metabolic changes
 • Why belly fat, fatigue, and cravings are connected to insulin resistance
 • The domino effect: how insulin resistance impacts cortisol, sleep, inflammation, and more
 • Which labs can help you understand what's happening in your body (hint: fasting insulin is key!)
 • Practical, modifiable lifestyle changes: movement, nutrition, sleep, and stress management

This isn't a personal failure; it's a physiological shift that deserves informed, compassionate support. Whether you're experiencing symptoms now or want to understand what's happening in your body, this episode will help you make sense of it all. 


Resources mentioned:
 • Town Crest Pharmacy
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Your Wise Self with SaraBy Sara