TL;DR

• We incubated 8 new nonprofits in Latin America using an evidence-based, cost-effectiveness–driven approach.
• Each organization is tackling a high-priority, neglected problem with proven interventions adapted to their context, all designed to scale.
• These orgs would not exist without this process, supporting them creates real counterfactual impact.
• 📅 We are hosting a “Meet the Founder” session on April 9th — connectors, funders, and mentors are invited to join and meet the teams.
• Donations are now open to support these new orgs pilots.

• 🚀 We are also opening applications for our 2026 cohort.

Why this work exists

In Latin America, many social organizations are driven by strong intentions — but far fewer are built around:

• rigorous prioritization
• strong causal evidence
• cost-effectiveness thinking

We started Theory of Change Makers (ToCM) to help close that gap.

Instead of launching a single organization, we asked:

What if we could help create many high-impact organizations, designed from day one around evidence, scale, and cost-effectiveness?

This post shares the result of this endeavor.

The process (briefly)

Over 8 months, founders:

1. Identified and prioritized problems using ITN (Importance, Tractability, Neglectedness)
2. Reviewed global evidence (RCTs, meta-analyses, systematic reviews)
3. Selected and adapted proven interventions
4. Built a Theory of Change
5. Developed a cost-effectiveness model
6. Tested [...]

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Outline:

(00:12) TL;DR

(00:58) Why this work exists

(01:37) The process (briefly)

(02:22) The organizations

(02:38) 💧 YAKU (Bolivia / Mexico) -- Water & Health

(03:12) 🧠 LUNAVA (Mexico) -- Mental Health

(03:50) 🧠 GRANA (Colombia) -- Mental Health

(04:32) 🍎 VIVIR BIEN (Guatemala) -- Child Health

(05:04) 📚 CAYAMBE (Ecuador) -- Education

(05:40) 💼 PROPIA (Spain / LATAM migrants) -- Livelihoods

(06:13) 🐔 CENTINELA (Chile / Mexico) -- Animal Welfare

(06:49) 🐣 DeNovo (Chile) -- Animal Welfare

(07:24) Why supporting these orgs matters

(07:47) 📅 Meet the Founders -- April 9th

(08:19) Event timing (2 hour meeting)

(09:10) 💛 Support the work

(09:35) Applications open -- ToCM 2026

(10:18) Acknowledgements

(10:45) Final reflection

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First published:

Source:

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Narrated by TYPE III AUDIO.