Life's dramatic and unexpected change keeps us vital and longing to see what will happen next. To experience, to travel, to be a loose-fitting component to a tightly fitted place. Anywhere one can be a loose component and absorb the unique experiences of societies and cultures where we will never fit.

I am not finished. It is easy to give up sometimes, especially when one feels tired, and abandoned, and, like many, the best is behind me. What is the point of continuing?

Like The Point, the point is to go on. One is never finished. The realm of the Gods will come fast enough.

Life's dramatic and unexpected change keeps us vital and longing to see what will happen next. To experience, to travel, to be a loose-fitting component to a tightly fitted place. Anywhere one can be a loose component and absorb the unique experiences of societies and cultures where we will never fit.

I am not finished. It is easy to give up sometimes, especially when one feels tired, and abandoned, and, like many, the best is behind me. What is the point of continuing?

Like The Point, the point is to go on. One is never finished. The realm of the Gods will come fast enough.

Investment success combines predicting the future, the confidence to make bold choices, and the fortitude to stay with those choices. Today's volatile and uncertain world requires new knowledge and perspective and assembling relevant facts from many diverse sources to make better decisions and achieve superior returns.

There is no simple formula. Thoughtful observation of complex factors, understanding their interrelation, and predicting the outcome of their interaction is challenging. Media-based quips are usually misguided, superficial, and potentially catastrophic.

Some of the world's most important industries are being profoundly impacted by new technological innovations and platforms, such as artificial intelligence, digital assets, blockchain-based businesses, gene editing, and DNA sequencing, enabling unprecedented disruption to business and economic models. Stable predictability is increasingly anachronistic. Every company or industry will either be a disrupter or disrupted. The leading growth companies of today stand an excellent chance to be memories tomorrow.

Distributed ledger technology (Blockchain) and digital assets have the potential to dramatically disrupt global equity and debt markets. This will decentralize critical data and enable an entirely new financial system where capital flows without the need for traditional intermediaries. It is an irreversible disruptive force transforming capital markets and the global financial system.

Digital currencies, crypto assets, digitized securities, and distributed ledgers require an enormous amount of power. While the combination of these assets is subject to tremendous hype, the environmental impact has been mostly ignored. However, this is changing because there has been increasing alarm about crypto's carbon footprint and environmental impact.

Technology is facing policy changes with global resonance, such as China's new crackdown, the rising resistance to social media, and government's desire to manage and control technological development. "I'll build a wall and we will be fine behind it." This did not work for China's First Emperor, and it will not work for its current one. The tech crackdown, regardless of any good intentions, will bring disastrous consequences. Regardless of any good intentions, this will add friction, inefficiency, and underperformance to the most dynamic global industry. The best intentions usually bring disastrous consequences.

Inflation fears, currency tremors, market jitters, and emotional vacillation causing joy and terror because all these outcomes seem equally likely. No realistic gauge is showing reliable directions for key metrics. Near-term data usually predicts the near-term future, and that usually gives us a reasonable sense of comfort about the markets, and how to plan, prepare, predict, and withstand anticipated market moves. But that is not the case now.

Drug development platforms such as mRNA, CRISPR, and gene therapies combined with cost-effective development are creating spectacular economic opportunities.

New firms are targeting large markets including treatments for cancer, auto-immune disease, and other pathologies of the immune system, the brain, and infectious diseases.

Economics assumes that supply and demand do not determine prices in financial markets. Asset-pricing theory says prices in financial markets are determined by expected future cash flows rather than buying and selling dynamics. Therefore, stocks and bonds are mostly immune from supply and demand determining prices. This is nonsense.

As with the ancient Ptolemaic model of our solar system that assumed the earth was at the center, efficient pricing theory is increasingly complex and inaccurate. Its fundamental assumption is wrong.