For 200,000 years, our species has been vulnerable to natural threats with the potential to eliminate humanity. Over the past 100 years, our technological advancements have reached a point where we now pose an anthropogenic risk to ourselves. From asteroids and A.I., to nuclear weapons and climate change, we discuss some of the known kill mechanisms that can bring about the extinction of our species and what, if anything, we can do to mitigate the risk.