In this week's episode of the Spine & Nerve podcast, Dr. Brian Joves and Dr. Nicolas Karvelas discuss opioid induced hyperalgesia (OIH)- a topic that is fairly controversial in the pain medicine world.

OIH is a medical process defined by worsening of pain with the use of opioids; typically patients will have evidence of central and peripheral sensitization including hyperesthesia and/or allodynia, and the pain can become more widespread/diffuse.  The doctors will discuss the theories behind the pathophysiology of OIH, including but definitely not limited to increased NMDA receptor activity. Lastly the doctors will address potential treatment options available to providers to help manage this very difficult to treat condition.

 

Listen as the doctors explore this interesting, and to some degree controversial topic.  Regardless of one’s final opinion on OIH, the potential impact of opioids of the nervous system (including the possibility of sensitization) is an important concept to be aware of and consider for any provider utilizing opioids to treat their patients.  

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This podcast is for information and educational purposes only, it is not meant to be medical advice. If anything discussed may pertain to you, please seek council with your healthcare provider. The views expressed are those of the individuals expressing them, they may not represent the views of Spine & Nerve.