ISTAART Voices

In this episode of ISTAART Voices, Dr. Sietske Sikkes and Dr. Mark Dubbelman reveal the complex challenges of pooling data from multiple Alzheimer's disease clinical trials. Their research highlights significant barriers in accessing and analyzing historical trial data, demonstrating the critical need for more open and streamlined scientific collaboration. This discussion underscores the importance of making clinical trial data more accessible to advance personalized medicine and understanding of Alzheimer's disease treatment responsiveness.

Special thanks to ISTAART Ambassador Lucy Core for her contributions to the production of this episode of ISTAART Voices.

Links

• Show page: alz.org/ISTAARTpodcast 
• ISTAART: alz.org/ISTAART 
• Featured paper: https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/trc2.12485
• Dr. Mark A. Dubbelman: https://connects.catalyst.harvard.edu/Profiles/display/Person/213733
• Dr. Sietske A. M. Sikkes: https://research.vu.nl/en/persons/sietske-sikkes
• Professional Interest Areas (PIAs): alz.org/ISTAARTPIAS 
• Podcast CMEs: alz.org/ISTAARTpodcastCME
• Alzheimer's Association International Conference® 2025 (AAIC®): alz.org/AAIC
• Alzheimer's Association Scientific Meetings: alz.org/scientificmeetings 
• Alzheimer's Association Journal Family: alz.org/journals 
• Social: #ISTAART @ISTAART 

The views and opinions expressed in this podcast are solely those of the guests and do not necessarily reflect those of the Alzheimer's Association. The Alzheimer's Association does not endorse any external product or service. This podcast is for informational purposes and is not intended to provide medical advice, please consult your physician.

Hosted on Acast. See acast.com/privacy for more information.

In this episode, Dr. Sylvie Belleville talks through the latest results from a trial involving older adults experiencing mild cognitive impairment. This work emphasizes how targeted cognitive training and memory interventions could potentially slow the progression of mild cognitive impairment and may help sustain long-term cognitive function. The trial results offer compelling perspectives on non-pharmacological interventions for delaying the onset of dementia in individuals experiencing early cognitive changes.

Special thanks to ISTAART Ambassador James Brady for his contributions to the production of this episode of ISTAART Voices.

Links

• Show page: alz.org/ISTAARTpodcast
• ISTAART: alz.org/ISTAART 
• Featured paper: https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/dad2.12626/utm_source=podcast&utm_medium=newsletter&utm_campaign=IVS1_SB&utm_id=ISTAARTVoicesTAARTVoices 
• Dr. Sylvie Belleville: https://recherche.umontreal.ca/english/our-researchers/professors-directory/researcher/is/in14272/
• Podcast CMEs: www.alz.org/ISTAARTpodcastCME
• Alzheimer's Association International Conference® 2025 (AAIC®): alz.org/AAIC
• Alzheimer's Association Scientific Meetings: alz.org/scientificmeetings 
• Alzheimer's Association Journal Family: alz.org/journals 
• Social: #ISTAART @ISTAART 

The views and opinions expressed in this podcast are solely those of the guests and do not necessarily reflect those of the Alzheimer's Association. The Alzheimer's Association does not endorse any external product or service. This podcast is for informational purposes and is not intended to provide medical advice, please consult your physician.

Hosted on Acast. See acast.com/privacy for more information.

Stressful life events like divorce and widowhood can have profound effects on brain health. In this episode of ISTAART Voices, Dr. Avinash Chandra shares his research exploring how marital dissolution may contribute to increased amyloid pathology and memory decline. His study offers compelling insights into the intricate relationship between life stress, brain biology, and cognitive aging, paving new avenues for understanding dementia risk factors.

Links

• Show page: alz.org/ISTAARTpodcast 
• ISTAART: alz.org/ISTAART 
• Featured paper: https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/dad2.70032/utm_source=podcast&utm_medium=newsletter&utm_campaign=IVS1_AC&utm_id=ISTAARTVoices 
• Dr. Avinash Chandra: https://www.qmul.ac.uk/wiph/people/profiles/chandra-avinash.html
• Podcast CMEs: www.alz.org/ISTAARTpodcastCME
• Alzheimer's Association International Conference® 2025 (AAIC®): alz.org/AAIC
• Tau Tau Global Conference 2025: alz.org/tau 
• Alzheimer's Association Scientific Meetings: alz.org/scientificmeetings 
• Alzheimer's Association Journal Family: alz.org/journals 
• Social: #ISTAART @ISTAART 

The views and opinions expressed in this podcast are solely those of the guests and do not necessarily reflect those of the Alzheimer's Association. The Alzheimer's Association does not endorse any external product or service. This podcast is for informational purposes and is not intended to provide medical advice, please consult your physician.

Hosted on Acast. See acast.com/privacy for more information.

New anti-amyloid therapies are transforming the treatment landscape for Alzheimer's disease. In this episode of ISTAART Voices, Dr. Gregory Jicha and Dr. Peter Nelson compare emerging Alzheimer's treatments to biologics used in cancer and other diseases. Their insightful analysis highlights the significance of new disease-modifying therapies, further illustrating why choices and access to treatment are crucial for individuals living with Alzheimer's disease.

Special thanks to ISTAART Ambassador Shloka Dhareshwar for her contributions to the production of this episode of ISTAART Voices.

Links

• Show page: alz.org/ISTAARTpodcast 
• ISTAART: alz.org/ISTAART 
• Featured paper: https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/trc2.12500?utm_source=podcast&utm_medium=newsletter&utm_campaign=IVS1_GJPN&utm_id=ISTAARTVoices
• Gregory A. Jicha: https://medicine.uky.edu/users/gajich2
• Peter T. Nelson: https://medicine.uky.edu/users/pnels2
• Clinicans’ Resources: www.alz.org/ISTAARTclinicians
• ALZ-NET: https://www.alz-net.org/ 
• Podcast CMEs: www.alz.org/ISTAARTpodcastCME
• Alzheimer's Association International Conference® 2025 (AAIC®): alz.org/AAIC
• Alzheimer's Association Scientific Meetings: alz.org/scientificmeetings 
• Alzheimer's Association Journal Family: alz.org/journals 
• Social: #ISTAART @ISTAART 

The views and opinions expressed in this podcast are solely those of the guests and do not necessarily reflect those of the Alzheimer's Association. The Alzheimer's Association does not endorse any external product or service. This podcast is for informational purposes and is not intended to provide medical advice, please consult your physician.

Hosted on Acast. See acast.com/privacy for more information.

Hearing loss increases the risk of developing dementia in later years. In this episode of ISTAART Voices, researchers Dr. Joshua Stevenson-Hoare and Dr. Kouki Tomida dissect the ways in which hearing loss may accelerate dementia progression. Through studies conducted in Germany and Japan, their works explore how early hearing difficulties and reduced conversation could signal future cognitive decline, offering compelling perspectives on early intervention and prevention strategies.

Special thanks to ISTAART Ambassador Michelle Chiu for her contributions to the production of this episode of ISTAART Voices.

Links

• Show page: alz.org/ISTAARTpodcast 
• ISTAART: alz.org/ISTAART 
• Featured paper 1: https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/dad2.12586/utm_source=podcast&utm_medium=newsletter&utm_campaign=IVS1_KT&utm_id=ISTAARTVoices 
• Featured paper 2: https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/dad2.12624/utm_source=podcast&utm_medium=newsletter&utm_campaign=IVS1_JSH&utm_id=ISTAARTVoices
• Dr. Kouki Tomida: https://orcid.org/0000-0002-7397-8224 
• Dr. Joshua Stevenson-Hoare: https://www.dkfz.de/en/clinical-epidemiology-and-aging-research/our-team 
• Podcast CMEs: www.alz.org/ISTAARTpodcastCME
• Alzheimer's Association International Conference® 2025 (AAIC®): alz.org/AAIC
• Alzheimer's Association Scientific Meetings: alz.org/scientificmeetings 
• Alzheimer's Association Journal Family: alz.org/journals 
• Social: #ISTAART @ISTAART 

The views and opinions expressed in this podcast are solely those of the guests and do not necessarily reflect those of the Alzheimer's Association. The Alzheimer's Association does not endorse any external product or service. This podcast is for informational purposes and is not intended to provide medical advice, please consult your physician.

Hosted on Acast. See acast.com/privacy for more information.

In this episode, Dr. Aleksandra Wojtas and Dr. Nicholas Seyfried discuss their latest research investigating the critical role of cerebrovascular dysfunction in Alzheimer's and related neurodegenerative diseases. They explain how analyzing the unique protein signatures found within the brain's blood vessels is uncovering new insights into the early development of Alzheimer's pathology. This innovative approach has the potential to lead to earlier detection methods and new treatment avenues.

Links

• Show page: alz.org/ISTAARTpodcast 
• ISTAART: alz.org/ISTAART 
• Featured paper: https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.13821?utm_campaign=IVS1_AMWNTS&utm_id=ISTAARTVoices&utm_medium=newsletter&utm_source=podcast
• Dr. Aleksandra M. Wojtas and Dr. Nicholas T. Seyfried: https://med.emory.edu/departments/biochemistry/research-labs/seyfried/people/index.html 
• Podcast CMEs: www.alz.org/ISTAARTpodcastCME
• Tau Global Conference 2025: alz.org/tau 
• Alzheimer's Association International Conference® 2025 (AAIC®): alz.org/AAIC
• Alzheimer's Association Scientific Meetings: alz.org/scientificmeetings 
• Alzheimer's Association Journal Family: alz.org/journals 
• Social: #ISTAART @ISTAART 

The views and opinions expressed in this podcast are solely those of the guests and do not necessarily reflect those of the Alzheimer's Association. The Alzheimer's Association does not endorse any external product or service. This podcast is for informational purposes and is not intended to provide medical advice, please consult your physician.

Hosted on Acast. See acast.com/privacy for more information.

In this episode, we explore the complex relationship between Alzheimer's and Lewy body pathologies. Our guest Dr. Duygu Tosun, explains how cutting-edge research methods are helping uncover this complex interplay of brain pathologies, and why understanding each individual's unique profile will be crucial for developing more personalized treatments in the future.

Special thanks to ISTAART Ambassador Yara Yakoub for her contributions to the production of this episode of ISTAART Voices.

Links

• Show page: alz.org/ISTAARTpodcast 
• ISTAART: alz.org/ISTAART 
• Featured paper: https://alz-journals.onlinelibrary.wiley.com/doi/full/10.1002/alz.13858?utm_source=podcast&utm_medium=newsletter&utm_campaign=IVS1_DTT&utm_id=ISTAARTVoices 
• Dr. Duygu Tosun-Turgut: https://radiology.ucsf.edu/people/duygu-tosun-turgut 
• ISTAART Alliance of Women Alzheimer's Researchers Professional Interest Area: www.alz.org/AWAREPIA  
• Podcast CMEs: www.alz.org/ISTAARTpodcastCME
• Alzheimer's Association International Conference® (AAIC®): alz.org/AAIC
• AAIC Neuroscience Next: alz.org/neurosciencenext 
• Alzheimer's Association Scientific Meetings: alz.org/scientificmeetings 
• Alzheimer's Association Journal Family: alz.org/journals 
• Social: #ISTAART @ISTAART 

The views and opinions expressed in this podcast are solely those of the guests and do not necessarily reflect those of the Alzheimer's Association. The Alzheimer's Association does not endorse any external product or service. This podcast is for informational purposes and is not intended to provide medical advice, please consult your physician.

Hosted on Acast. See acast.com/privacy for more information.

In this episode, we speak with Dr. Mohammad Fili and Dr. Auriel Willette about the exciting applications of machine learning and brain imaging in the context of Alzheimer's disease and related dementias. They explain how combining emerging technologies with existing large datasets can uncover compelling patterns in the brain that distinguish those on a trajectory of cognitive decline from those who maintain or even improve their mental abilities as they age.

Links

• Show page: alz.org/ISTAARTpodcast 
• ISTAART: alz.org/ISTAART 
• Featured paper: https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/dad2.12595/utm_source=podcast&utm_medium=newsletter&utm_campaign=IVS1_Mohammad&utm_id=ISTAARTVoices  
• Dr. Mohammad Fili: https://ceat.okstate.edu/iem/people/mohammad-fili-faculty-profile.html 
• Dr. Auriel Willette: https://ifh.rutgers.edu/faculty_staff/auriel-a-willette-ba-ms-phd/ 
• Podcast CMEs: www.alz.org/ISTAARTpodcastCME
• ISTAART Ambassador Program: www.alz.org/ISTAARTambassadors 
• Alzheimer's Association International Conference® (AAIC®): alz.org/AAIC
• Alzheimer's Association Scientific Meetings: alz.org/scientificmeetings 
• Alzheimer's Association Journal Family: alz.org/journals 
• Social: #ISTAART @ISTAART 

The views and opinions expressed in this podcast are solely those of the guests and do not necessarily reflect those of the Alzheimer's Association. The Alzheimer's Association does not endorse any external product or service. This podcast is for informational purposes and is not intended to provide medical advice, please consult your physician.

Hosted on Acast. See acast.com/privacy for more information.

Alzheimer's disease profoundly affects the LGBTQIA+ community, yet research remains limited. In this episode, we speak with Dr. Jace Flatt about the risks and disparities LGBTQIA+ older adults face regarding cognitive decline and dementia. We uncover the challenges they navigate and explore innovative approaches to engage them in research.

Links

• Show page: alz.org/ISTAARTpodcast 
• ISTAART: alz.org/ISTAART 
• Featured paper: https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/trc2.12477/utm_source=podcast&utm_medium=newsletter&utm_campaign=IVS1_JasonF&utm_id=ISTAARTVoices
• Dr. Jason D. Flatt: https://www.unlv.edu/people/jason-flatt 
• ISTAART Diversity and Disparities Professional Interest Area: www.alz.org/DDisparitiesPIA 
• Alzheimer's Association LGBTQ+ Community Resources for Dementia: www.alz.org/lgbtq 
• Alzheimer's Association Help Line: www.alz.org/helpline 
• Podcast CMEs: www.alz.org/ISTAARTpodcastCME
• Alzheimer's Association International Conference® 2024 (AAIC®): alz.org/AAIC
• Alzheimer's Association Scientific Meetings: alz.org/scientificmeetings 
• Alzheimer's Association Journal Family: alz.org/journals 
• Social: #ISTAART @ISTAART 

The views and opinions expressed in this podcast are solely those of the guests and do not necessarily reflect those of the Alzheimer's Association. The Alzheimer's Association does not endorse any external product or service. This podcast is for informational purposes and is not intended to provide medical advice, please consult your physician.

Hosted on Acast. See acast.com/privacy for more information.

In this episode, we sit down with postdoctoral researcher Dr. Dana Pourzinal, to discuss her work exploring the varied cognitive profiles of Parkinson's disease. Through an international collaboration, this research identifies distinct subtypes of cognitive decline, shedding light on the complexity of Parkinson's. By pinpointing these diverse cognitive patterns, this work aims to enable earlier interventions and enhance the quality of life for those living with this neurodegenerative disorder.

Links

• Show page: alz.org/ISTAARTpodcast 
• ISTAART: alz.org/ISTAART 
• Featured paper: https://alz-journals.onlinelibrary.wiley.com/doi/epdf/10.1002/dad2.12625
• Dr. Dana Pourzinal: https://about.uq.edu.au/experts/44547 
• Podcast CMEs: alz.org/ISTAARTpodcastCME
• Alzheimer's Association International Conference® (AAIC®): alz.org/AAIC
• Alzheimer's Association Scientific Meetings: alz.org/scientificmeetings 
• Alzheimer's Association Journal Family: alz.org/journals 
• Social: #ISTAART @ISTAART 

The views and opinions expressed in this podcast are solely those of the guests and do not necessarily reflect those of the Alzheimer's Association. The Alzheimer's Association does not endorse any external product or service. This podcast is for informational purposes and is not intended to provide medical advice, please consult your physician.

Hosted on Acast. See acast.com/privacy for more information.