JACC's February 24 issue is a mini-spotlight issue on the ACHD Guidelines. In this discussion, Lidija B. McGrath, MD, provides additional early career perspective on the 2025 Adult Congenital Heart Disease (ACHD) guidelines. In the interview with JACC Consultant Carla P. Rodriguez-Monserrate, MD, they highlight the value of the guideline as a practical decision aid for clinical care, education, and shared decision making. They discuss key updates including expanded anatomic physiologic classification, greater alignment with real world systems of care, and an increased emphasis on transition, equity, and collaboration with non ACHD specialists. The conversation underscores how the updated guidelines are designed to support clinicians across diverse practice settings while improving care for a growing and complex ACHD population.

Early diagnosis in transthyretin cardiac amyloidosis (ATTR CM) matters more than ever. Adith Arun talks with Dr. Ahmad Masri about key findings from the ATTRIBUTE CM phase 3 trial on acoramidis, what recurrent event analyses reveal, and why delays in suspicion, diagnosis, or treatment can meaningfully impact outcomes. They also explore challenges in clinical pathways, updates in the therapeutic landscape, and the biggest unmet needs as patients live longer with disease directed therapy.

Learn more about the ACHD guideline in JACC's February 24 issue. In our latest interview, JACC Consultant Yonatan Buber, MD, FACC joins author Patrick T O'Gara, MD, MACC to discuss key insights from the 2025 Adult Congenital Heart Disease guidelines and how they intersect with the 2020 ACC/AHA Valvular Heart Disease guidelines. The conversation highlights the importance of multidisciplinary, shared decision-making for younger ACHD patients, particularly when valve interventions have lifelong implications. They also explore how clinicians can thoughtfully navigate between guidelines, balance limited evidence with expert consensus, and refer patients to experienced ACHD centers to optimize long-term outcomes.

The ACHD Guideline gets expert perspectives in JACC's February 24 mini-focus issue. In this interview, join JACC Consultant Sitaram M. Emani, MD, speak with commentary author Emile A. Bacha, MD, FACC, about the maturation of the Adult Congenital Heart Disease (ACHD) specialty following the release of new AHA/ACC guidelines. Dr. Bacha emphasizes the necessity of a multidisciplinary "team sport" approach to care and highlights critical updates regarding earlier surgical intervention, the management of complex Fontan patients, and the treatment of vascular rings. The conversation also addresses the current shortage of ACHD specialists and the evolving nature of the field as new cohorts of complex pediatric survivors transition into adult care.

JACC's February 17 issue gives readers a comprehensive focus issue on women's cardiovascular health, a long overlooked field of study. In this interview, JACC Associate Editor Makoto Mori, MD, joins resident Catherine M. Wagner, MD, MSc, to discuss her brief report on sex differences in tricuspid valve repair during mitral surgery, highlighting that women with moderate or severe tricuspid regurgitation are less likely than men to receive concomitant repair. The findings suggest that reliance on an absolute annular size threshold rather than an indexed threshold may contribute to undertreatment of women, as indexed measurements better reflect disease severity in smaller body sizes. The study emphasizes the need to move toward personalized, indexed criteria in surgical guidelines to reduce care gaps and improve outcomes for women.

In JACC's February 17 issue on Women's Heart Health. JACC Deputy Editor Erica Spatz, MD, joins author and JACC Associate Editor Michael Honigberg, MD, FACC, to discuss the need to rethink cholesterol management in women by moving beyond short term, age driven risk calculators toward a life course approach that accounts for cumulative exposure to atherogenic lipoproteins. His piece in our focus issue highlights opportunities for earlier, individualized prevention—including shared decision making around statin therapy and careful consideration of reproductive goals—to better reduce long term cardiovascular risk in women.

Early diagnosis in transthyretin cardiac amyloidosis (ATTR-CM) matters more than ever. Adith Arun talks with Dr. Ahmad Masri about key findings from the ATTRIBUTE-CM phase 3 trial on acoramidis, what recurrent event analyses reveal, and why delays in suspicion, diagnosis, or treatment can meaningfully impact outcomes. They also explore challenges in clinical pathways, updates in the therapeutic landscape, and the biggest unmet needs as patients live longer with disease-directed therapy.

JACC is pleased to publish this study from authors Nicole J. van Steijn, MD and Michiel M. Winter MD, PhD, featuring the results of integrating Apple Watch monitoring into a clinical workflow. In this video interview accompanying the article, JACC: Associate Editor Xiaoxi Yao, PhD, MPH, MS joins first author Nicole van Steijn, MD, to discuss how findings led to a fourfold increase in early atrial fibrillation detection among high risk patients. Timely ECG review within an established e health program enabled rapid diagnosis and highlights the importance of infrastructure and reimbursement for scalable use of wearable technologies. The conversation explores how consumer wearables may play an expanding role in AF screening, stroke prevention, and future cardiovascular care.

This JACC Author Interview features Karen Joynt Maddox, MD, MPH, and JACC Executive Associate Editor Mitsuaki Sawano, MD, discussing this paper published in the March 24 issue of JACC. The paper looks into cardiovascular care and outcomes among Medicare beneficiaries during the late phase of the COVID-19 pandemic (2021–2022). The research reveals persistent reductions in hospitalizations, increased outpatient visits driven by telehealth, and a concerning 20% rise in mortality—especially among socially vulnerable populations and Medicare Advantage enrollees. In this in-depth author interview, learn about potential biological, behavioral, and systemic factors behind these trends and the importance of strengthening healthcare resilience for future crises. #jacc #jaccjournals

In this episode of Behind the Science, Adith Arun, BS, speaks with Paul Lacaze, PhD, and Sultana Monira Hussain, PhD about their study in JACC's January 6 issue, examining loss of the Y chromosome (LOY) in older men and its association with cardiovascular disease. They discuss the study design, analytical approach, and key findings linking LOY to an increased risk of major adverse cardiovascular events, particularly myocardial infarction. The conversation explores potential biological mechanisms underlying these associations, the strengths and limitations of the data, and how LOY could emerge as a novel biomarker for cardiovascular risk stratification in men. The episode also looks ahead to future research directions and possible clinical applications. #jacc #jaccjournals #behindthescience