How can AI systems reason safely in the open world of medicine? JAMA+ AI Associate Editor Yulin Hswen, ScD, MPH, talks with Eric Horvitz, MD, PhD, Chief Scientific Officer at Microsoft, about the future of AI in 5 years to 100 years, from neurons to the nebulous, and how we can guide AI to be copilots while maintaining integrity and safety in the clinical arena. Related Content:

• AI—Days of Future Past

Will AI usher in a new era of rapid drug discovery? In this episode of JAMA+ AI Conversations, Editor in Chief Roy Perlis interviews Ajamete Kaykas, Chief eXploration Officer at Insitro, a biotech company looking to apply AI to develop new therapeutics. Related Content:

• AI in the Lab—Will It Really Change Drug Discovery?

Derek Angus, MD, MPH, joins JAMA+ AI Editor in Chief Roy Perlis, MD, MSc, to discuss a special communication from JAMA Summit: Artificial Intelligence. Related Content:

• What the Experts Think About Where AI Is Headed
• AI, Health, and Health Care Today and Tomorrow

How will 2026 shape the world of AI in health? Editor in Chief Roy Perlis and Associate Editor Yulin Hswen discuss in this special episode marking one year since the launch of JAMA+ AI. Hosted by Roy H. Perlis, MD, MSc and Yulin Hswen, ScD, MPH. Related Content:

• What Will Next Year Bring for AI in Health?
• Detection of Epileptogenic Focal Cortical Dysplasia Using Graph Neural Networks
• Evaluating a Large Language Model in Translating Patient Instructions to Spanish Using a Standardized Framework
• Public Perception of Physicians Who Use Artificial Intelligence
• Assessment of Machine Learning to Estimate the Individual Treatment Effect of Corticosteroids in Septic Shock
• Artificial Intelligence Across the JAMA Network
• Early Warning Scores With and Without Artificial Intelligence
• Artificial Intelligence and Radiologist Burnout
• Complete AI-Enabled Echocardiography Interpretation With Multitask Deep Learning
• How AI Could Reshape Health Care—Rise in Direct-to-Consumer Models
• Artificial Intelligence–Enabled Wearable Devices and Nocturnal Scratching in Mild Atopic Dermatitis

How is Google Search evolving with AI and how do we ensure that language models maintain safety? JAMA+ AI Editor in Chief Roy Perlis, MD, talks with Michael Howell, MD, chief health officer at Google, about how he aims to balance innovation and safety in AI-driven medicine, building on his own work in hospital-based quality and safety. Related Content:

• "15% of Searches Have Never Been Typed Before"
• Three Epochs of Artificial Intelligence in Health Care

In this special edition of JAMA+ AI Conversations, editor in chief Roy Perlis is joined by Linda Brubaker, editor in chief of JAMA+ Women's Health and deputy editor at JAMA. They speak with Linda Moy, inaugural vice chair of AI for the NYU Department of Radiology and former editor of Radiology, about the opportunities and risks of applying AI in medical imaging. Will these new tools be a net positive for women's health? Related Content:

• The Promise and Challenge of AI for Women's Health

Michelle Mello, JD, PhD, MPhil, professor of law and health policy at Stanford University, joins JAMA+ AI Editor in Chief Roy Perlis, MD, MSc, to discuss her recently published JAMA Perspective that lays out a framework for when and how health care organizations should disclose AI use to patients. Dr Mello shares insights on the importance of patient trust and surveys that suggest many patients currently mistrust the use of AI in their care. Related Content:

• Ethical Obligations to Inform Patients About Use of AI Tools
• AI Disclosure and Patient Consent in Health Care

In this episode of JAMA+ AI Conversations, Microsoft CMO David Rhew, MD, discusses his journey from clinical practice to technology leadership, rapid progress in AI, its potential impacts on health care, and the challenges and opportunities that lie ahead for clinicians and researchers. Related Content:

• Changing Opinions About AI in Health Care

In this follow-up to a 2017 interview with JAMA Medical News, the University of Southern California's Maja Matarić, PhD, the computer scientist who pioneered the field of socially assistive robotics, discusses how artificial intelligence is advancing the field in areas ranging from autism to physical rehabilitation to anxiety and depression. Related Content:

• Social Robots That Help Support People's Health Are Getting a Boost From AI
• Socially Assistive Robots

3D total-body photography is used to detect lesions and melanoma in patients at high risk of developing skin cancer. The cost-effectiveness of this technology was examined in a recent study published in JAMA Dermatology. Roy Perlis, Editor in Chief of JAMA+ AI, joins economist Daniel Lindsay, PhD, to discuss the clinical and economic outcomes of this recent study. Related Content:

• Cost-Effectiveness Analysis of 3D Total-Body Photography for People at High Risk of Melanoma
• Can AI Improve the Cost-Effectiveness of 3D Total-Body Photography?