The extracellular matrix (ECM) biomechanically regulates nephrogenesis, and abnormal ECM is a histologic feature of kidney aging and disease. Two reports in this issue use state-of-the-art methods to characterize the ECM in development, aging and disease.

Transplant candidates with top 20% Estimated Post-Transplant Survival (EPTS) scores are prioritized to receive optimal deceased-donor kidneys. A study found fewer than half of eligible ESKD patients w/ top 20% EPTS scores were on transplant waiting list.

A few articles in each issue are chosen by the EIC for their interest. The issue highlights include: laminin-521 –a novel GBM autoantigen, iron biomarkers & mortality in nondialysis kidney disease, & disparities among hemodialysis patients with COVID-19.

A conversation with EIC, Josie Briggs and leading nephrology clinical trialist, Vlado Perkovic - on the next generation of clinical trials in nephrology.

Each issue of JASN contains Highlights, short summaries of a few of the articles in the issue, chosen by the EIC as of special interest to our readers.

Each issue of JASN contains Highlights, short summaries of a few of the articles in the issue, chosen by the EIC as of special interest to our readers.

In this podcast JASN EIC, Josie Briggs talks with transplant expert and JASN Associate Editor, Matt Griffin about two studies that examine the immune responses to COVID-19 in transplant patients.

Josie Briggs talks with Nicholas Steers about his work using inbred mice strains to understand the genetic factors that result in collapsing focal segmental glomerulosclerosis in HIV nephropathy, insights also relevant to a rare complication of COVID-19.

In this episode, Dr. Josie Briggs and Dr. Brendon Neuen discuss the GFR paradox: SGLT inhibitors and other kidney-protective drugs initially cause a drop in GFR.

Kidney patients are at high risk for cardiovascular disease. In this Podcast, Dr. Briggs talks and Dr. David Charytan discuss recent work to improve the prediction of CVD in kidney patients. New work from CRIC aims to update the Framingham equation.