Prolonged screen exposure and sedentary behaviors are increasingly associated with musculoskeletal dysfunction in the digital era. This narrative review synthesizes current literature examining the relationship between digital behavior and orthopedic pathology, outlining proposed mechanisms, clinical presentations, and preventive strategies. Searches of PubMed, Google Scholar, and ScienceDirect (2000–2025) identified clinical, biomechanical, and epidemiologic evidence related to posture-associated musculoskeletal disorders. Sustained screen use and poor ergonomics are associated with cumulative strain on the cervical, thoracic, and lumbar spine. Proposed physiologic mediators, including muscle fatigue, altered proprioception, and altered spinal loading patterns, may contribute to neck pain, shoulder impingement, carpal tunnel syndrome, and lumbar strain. These conditions are commonly reported among students, remote workers, and healthcare professionals. Interventions focused on ergonomic modification, postural re-education, and osteopathic or physical rehabilitation demonstrate improvements in pain and functional outcomes in selected populations. Although screen-related biomechanical strain is increasingly prevalent, additional longitudinal research is needed to clarify causality and long-term orthopedic implications. Early preventive strategies may help mitigate chronic musculoskeletal dysfunction.