JTO Insights

Episode 3: In this episode of JTO Insights, Editor-in-Chief Dr. Alex Adjei and Associate Editor Dr. Tom John host authors of two articles published in the May issue of the Journal of Thoracic Oncology. Dr. Bonnie Ky, Founder’s Professor of Cardio-Oncology at the Perelman School of Medicine, University of Pennsylvania, discusses their article “Changes in Cardiac Function in Patients Receiving Radiation Therapy for Lung Cancer”; and Dr. David Planchard, Head of Thoracic Group at Gustave Roussy, discusses their article “Trastuzumab Deruxtecan in Patients with HER2-Overexpressing Non-Small Cell Lung Cancer: Results From Part 1 of the Open-label, Multicenter, Phase 1b DESTINY-Lung03 Trial.”

Recommended Reading:

1. Changes in Cardiac Function in Patients Receiving Radiation Therapy for Lung Cancer: https://www.jto.org/article/S1556-0864(26)00002-X/fulltext

2. Trastuzumab Deruxtecan in Patients with HER2-Overexpressing Non-Small Cell Lung Cancer: Results From Part 1 of the Open-label, Multicenter, Phase 1b DESTINY-Lung03 Trial: https://www.jto.org/article/S1556-0864(25)03021-7/fulltext

3. JTO May 2026 Issue: https://www.jto.org/issue/S1556-0864(26)X2003-2

Podcast Hosts:

-Alex A. Adjei, MD, PhD, FACP, Editor-in-Chief, Journal of Thoracic Oncology; Chief, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA

-Thomas John, MBBS, PhD, Associate Editor, Journal of Thoracic Oncology, Deputy Director, Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia

Podcast Guests:

-David Planchard, MD, Department of Medical Oncology, Thoracic Group, Institut Gustave Roussy, Villejuif, France

-Bonnie Ky, MD, MSCE, Division of Cardiology, Perelman School of Medicine, University of Pennsylvania, Pennsylvania, United States

Episode 2: In this episode of JTO Insights, Editor-in-Chief Dr. Alex Adjei and Associate Editor Dr. Tom John host authors of two articles published in the JTO 20th Anniversary Series.

Dr. Michele Carbone, Director of the Thoracic Oncology Program at the University of Hawaii Cancer Center, joins us to discuss their article, “Advances in the Basic Sciences in Thoracic Oncology in the Last 20 Years and Their Translational Impact"; and Dr. Jeff Bogart, Distinguished Professor and Chair of Radiation Oncology of SUNY Upstate Medical University, New York, joins to discuss their article, "The Optimization of Radiotherapy in Lung Cancer Treatment: 20 Years of Progress".

Recommended Reading:

1. JTO 20th Anniversary Series: https://www.jto.org/content/20thAnniversarySeries

2. "Advances in the Basic Sciences in Thoracic Oncology in the Last 20 Years and Their Translational Impact": https://www.jto.org/article/S1556-0864(25)02895-3/fulltext

3. "The Optimization of Radiotherapy in Lung Cancer Treatment: 20 Years of Progress": https://www.jto.org/article/S1556-0864(26)00031-6/fulltext

Podcast Hosts:

-Alex A. Adjei, MD, PhD, FACP, Editor-in-Chief, Journal of Thoracic Oncology; Chief, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA

-Thomas John, MBBS, PhD, Associate Editor, Journal of Thoracic Oncology, Deputy Director, Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia

Podcast Guests:

-Michele Carbone, MD, PhD, Thoracic Oncology Program, University of Hawaii Cancer Center, Hawaii, United States

-Jeffrey A. Bogart, MD, SUNY Upstate Medical University, New York, United States

Episode 1: In this episode of JTO Insights, Editor-in-Chief Dr. Alex Adjei and Associate Editor Dr. Tom John host authors of two articles published in the Journal of Thoracic Oncology April 2026 issue.

Dr. Timothy F. Burns, Professor of Medicine in the Division of Medical Oncology at the Ohio State University Comprehensive Cancer Center, joins us to discuss their article "Efficacy and Safety of Olomorasib in Combination with Pembrolizumab in Treatment of Patients with KRAS G12C-Mutant Advanced NSCLC"; and Dr. Paaladinesh Thavendiranathan of Division of Cardiology, Peter Munk Cardiac Center at the Toronto General Hospital and the Director of the Ted Rogers Program in Cardiotoxicity Prevention joins to discuss their article, "The risk of cardiovascular adverse outcomes in patients with thymoma or thymic carcinoma receiving cancer therapy".

Key Topics Covered:

• KRAS G12C-mutant NSCLC

• Thymoma

• Cardiovascular adverse outcomes

Recommended Reading:

1. April 2026 JTO Issue: https://www.jto.org/issue/S1556-0864(26)X2002-0

2. "Efficacy and Safety of Olomorasib in Combination with Pembrolizumab in Treatment of Patients with KRAS G12C-Mutant Advanced NSCLC": https://www.jto.org/article/S1556-0864(25)02936-3/fulltext

3. "The risk of cardiovascular adverse outcomes in patients with thymoma or thymic carcinoma receiving cancer therapy": https://www.jto.org/article/S1556-0864(25)02940-5/fulltext

Podcast Hosts:

-Alex A. Adjei, MD, PhD, FACP, Editor-in-Chief, Journal of Thoracic Oncology; Chief, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA

-Thomas John, MBBS, PhD, Associate Editor, Journal of Thoracic Oncology, Deputy Director, Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia

Podcast Guests:

-Timothy F. Burns, MD, PhD, Professor of Medicine, Division of Medical Oncology, The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OH, USA

-Dinesh Thavendiranathan, MD, SM, FRCPC, Professor of Medicine, Director, Ted Rogers in Cardiotoxicity Prevention, Peter Munk Cardiac Center, Toronto General Hospital, University of Toronto, Canada

Welcome to JTO Insights, the official podcast of the IASLC Journal of Thoracic Oncology (JTO).

Hosts Dr. Alex Adjei and Dr. Tom John introduce the new podcast and its mission to deliver concise, accessible insights from the latest JTO research. Each episode features expert discussions with authors, highlighting key studies, clinical implications, and future directions in thoracic oncology.

Designed for clinicians, researchers, and healthcare professionals, JTO Insights helps you quickly stay informed on the most impactful advances in the field. Subscribe now so you don’t miss an episode – JTO Insights launces this April 2026 and visit jto.org for full articles and additional research.

Co-Hosts:

• Alex A. Adjei, MD, PhD, FACP, Editor-in-Chief, Journal of Thoracic Oncology, Chief, Taussig Cancer Institute, Cleveland Clinic, OH, USA

• Thomas John, MBBS, PhD, Associate Editor, Journal of Thoracic Oncology, Deputy Director, Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia