This study investigates the effects of dietary supplementation with maqui (Aristotelia chilensis) in obese mice induced by a high-fat diet. The results indicate that maqui supplementation improves insulin sensitivity, reduces weight gain, and enhances thermogenic activity. Specifically, maqui supplementation was found to induce a brown-like phenotype in subcutaneous white adipose tissue (scWAT), marked by increased expression of genes involved in thermogenesis, de novo lipogenesis, and fatty acid oxidation. Additionally, these beneficial effects may be linked to improved FGF21 signaling and upregulation of key metabolic regulators, including Chrebpb, CREG1, PGC1a, and SREBP1c. DOI: 10.3390/antiox8090360