Keeping InSight

According to the World Health Organization (WHO), social determinants of health (SDOH) are defined as the circumstances in which humans are born, develop, live, earn, and age. They are non-medical factors that influence health outcomes. The
distribution of money, power, and resources shapes these circumstances1. These socioeconomic variables contribute to societal stratification and health disparities among persons of different social and economic classes, genders, and ethnicity.

In this episode our MSL co-hosts Shweta Kulkarni, PhD and Mary Voelmle NP, CDCES have a conversation with Shideh Majidi, MD on how the landscape and incidence of T1D diagnosis and treatment is changing. Dr. Majidi identifies key barriers and attitudes that physicians and other healthcare providers may encounter when discussing screening for type 1 diabetes, particularly among patients from under resourced communities with unique challenges that are encountered daily. We conclude the episode with concrete actions and resources our listeners can use to begin to narrow the gap on healthcare disparities within under resourced communities when approaching patients and their families on education on the incidence of T1D and the option to potentially screen for T1D.

Supporting literature from episode:
1. Felicia Hill-Briggs et al. Social Determinants of Health and Diabetes: A Scientific Review. Diabetes Care 1 January 2021; 44 (1): 258–279. https://doi.org/10.2337/dci20-0053.
2. Chelak K, Chakole S. The Role of Social Determinants of Health in Promoting Health Equality: A Narrative Review. Cureus. 2023 Jan 5;15(1):e33425. doi:10.7759/cureus.33425. PMID:36751221; PMCID: PMC9899154.
3. T1D Exchange Quality Improvement Collaborative; Driving Equity and Innovation in the T1D Exchange Quality Improvement Collaborative: Advancing Outcomes Through Collaborative Change. https://doi.org/10.2337/cd23-0070.
4. Alkhatib EH, Majidi S. et al. Feasibility of caregiver diabetes distress screening in routine clinical care of youth with type 1 diabetes. Diabet Med. 2024; 00:e15416. doi:10.1111/dme.15416.
5. Divers J, et al. MMWR Morb Mortal Wkly Rep. 2020; 69(6):161-165.
6. Majidi S, et al. T1D Exchange Quality Improvement Collaborative Study Group. Inequities in Health Outcomes in Children and Adults With Type 1 Diabetes: Data From the T1D Exchange Quality Improvement Collaborative. Clin Diabetes. 2021 Jul;39(3):278-283. doi: 10.2337/cd21-0028. PMID: 34421203; PMCID: PMC8329009.
7. Moshe Phillip, Linda A. DiMeglio et al.; Consensus Guidance for Monitoring Individuals With Islet Autoantibody–Positive Pre-Stage 3 Type 1 Diabetes. Diabetes Care 25 July 2024; 47 (8): 1276–1298. https://doi.org/10.2337/dci24-0042.

Music: Spark of Inspiration by Shane Ivers - https://www.silvermansound.com

This program is non-promotional and sponsored by Sanofi. Presenter(s) were compensated and/or received an honorarium from Sanofi in connection with this program. This program does not constitute an endorsement by Sanofi of any particular organization or its programming. Additional resources and information may be available and should be investigated.

This podcast is intended for US residents only. Sanofi does not provide medical advice, diagnosis, or treatment. The health information contained herein is provided for general educational purposes only. Your healthcare professional is the best source of information regarding your health. Please consult your healthcare professional if you have any questions about your health or treatment.

In this episode, we will feature a compelling discussion with Dr. Teresa Quattrin, MD on addressing the challenges posed by social determinants of health in the screening process for Type 1 Diabetes (T1D). Our MSL co-hosts, Anil Jacob, PharmD, and Mary Voelmle, NP, CDCES, engage Dr. Quattrin in an insightful conversation about breaking down barriers and overcoming challenges faced by under-resourced communities. Dr. Quattrin sheds light on key obstacles and attitudes healthcare providers may encounter, especially when discussing T1D screening among racial and ethnic minority populations. We conclude by providing actionable strategies and resources that our listeners can utilize to narrow the healthcare disparity gap. This includes practical guidance on how to approach patients and their families regarding education on T1D screening. 

Supporting literature from episode: 
1. Felicia Hill-Briggs, et al. Social Determinants of Health and Diabetes: A Scientific Review. Diabetes Care 1 January 2021;44 (1):258–279. https://doi.org/10.2337/dci20-0053.

2. Chelak K, Chakole S. The Role of Social Determinants of Health in Promoting Health Equality: A Narrative Review. Cureus. 2023 Jan 5;15(1):e33425. doi: 10.7759/cureus.33425. PMID: 36751221. PMCID: PMC9899154. 

3. A H Mokdad, et al. Diabetes trends in the U.S.: 1990-1998. Diabetes Care. 1 September 2000; 23(9):1278–1283. https://doi.org/10.2337/diacare.23.9.1278. 

4. Denys T. Lau, et al. 2023:Data Related to Social Determinants of Health Captured in the National Health and Nutrition Examination Survey. American Journal of Public Health. 113;1290-1295. https://doi.org/10.2105/AJPH.2023.307490.

5. Moshe Phillip, et al. Consensus Guidance for Monitoring Individuals With Islet Autoantibody–Positive Pre-Stage 3 Type 1 Diabetes. Diabetes Care. 25 July 2024; 47(8):1276–1298. https://doi.org/10.2337/dci24-0042.

6. Sofia Learns About Research: https://www.research.buffalo.edu/sofia/

Music: Spark of Inspiration by Shane Ivers - https://www.silvermansound.com

MAT-US-2500094(v1.0)-P
Approved Distribution
Exp: 11/6/2026

This program is non-promotional and sponsored by Sanofi. Presenter(s) were compensated and/or received an honorarium from Sanofi in connection with this program. This program does not constitute an endorsement by Sanofi of any particular organization or its programming. Additional resources and information may be available and should be investigated.

This podcast is intended for US residents only. Sanofi does not provide medical advice, diagnosis, or treatment. The health information contained herein is provided for general educational purposes only. Your healthcare professional is the best source of information regarding your health. Please consult your healthcare professional if you have any questions about your health or treatment.

In this episode our hosts Katie McMurry, PharmD (US Transplant MSL) and Amber Lawson, PharmD (US Transplant MSL) have a conversation with Dr. Michael Verneris, MD. Dr. Verneris is a Professor of Pediatrics and the Barton Family Endowed Chair of Bone Marrow Transplant at the University of Colorado Denver School of Medicine. He also serves as the Director of Bone Marrow Transplantation and Cellular Therapy at the Children’s Hospital Colorado. In addition, he is currently serving as Vice Chair of the Pediatric Blood and Marrow Transplant Consortium (PBMTC).  Dr. Verneris will take us through some of the impacts socioeconomic status has on hematopoietic cell transplant outcomes in the pediatric population as well as some of the data gaps that need to be addressed going forward in this patient population.  

Supporting Literature and References: 

1. “Neighborhood poverty and pediatric allogeneic hematopoietic cell transplantation outcomes: a CIBMTR analysis”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7845011/ 
2. “Prevalence and Impact of Financial Hardship among New England Pediatric Stem Cell Transplantation Families” https://pubmed.ncbi.nlm.nih.gov/25445021/  
3. “Social determinants of health predict health outcomes following pediatric allogeneic hematopoietic stem cell transplant” https://pubmed.ncbi.nlm.nih.gov/38302730/  
4. “Social regulation of human gene expression: mechanisms and implications for public health” https://pubmed.ncbi.nlm.nih.gov/23927506/   
5. “The conserved transcriptional response to adversity” https://pubmed.ncbi.nlm.nih.gov/31592179/   
6. “Alterations in leukocyte transcriptional control pathway activity associated with major depressive disorder and antidepressant treatment” https://pubmed.ncbi.nlm.nih.gov/27219347/  
7. “Low socioeconomic status, adverse gene expression profiles, and clinical outcomes in hematopoietic stem cell transplant recipients” https://pubmed.ncbi.nlm.nih.gov/26286914/  
8. “Molecular correlates of socioeconomic status and clinical outcomes following hematopoietic cell transplantation for leukemia” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859844/  
9. “The health risk of social disadvantage is transplantable into a new host” https://pubmed.ncbi.nlm.nih.gov/39008669/   
10. “Mindfulness-Based Stress Reduction training reduces loneliness and pro-inflammatory gene expression in older adults: A small randomized controlled trial” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3635809/  
11. “Yogic meditation reverses NF-kappa B and IRF-related transcri

This program is non-promotional and sponsored by Sanofi. Presenter(s) were compensated and/or received an honorarium from Sanofi in connection with this program. This program does not constitute an endorsement by Sanofi of any particular organization or its programming. Additional resources and information may be available and should be investigated.

This podcast is intended for US residents only. Sanofi does not provide medical advice, diagnosis, or treatment. The health information contained herein is provided for general educational purposes only. Your healthcare professional is the best source of information regarding your health. Please consult your healthcare professional if you have any questions about your health or treatment.

In this episode our hosts Jessica Driscoll, DNP (US Transplant MSL) and Katie McMurry, PharmD (US Transplant MSL) have a conversation with Amanda Ferraro, a patient advocate for chronic graft-versus-host disease and the complications associated with stem cell transplant. A leukemia and stem cell transplant survivor, Amanda lives with chronic graft-versus-host disease and speaks candidly about her journey. Her mission is to help others by validating the challenges associated with stem cell transplant and facilitating these crucial conversations.  

This program is non-promotional and sponsored by Sanofi. Presenter(s) were compensated and/or received an honorarium from Sanofi in connection with this program. This program does not constitute an endorsement by Sanofi of any particular organization or its programming. Additional resources and information may be available and should be investigated.

This podcast is intended for US residents only. Sanofi does not provide medical advice, diagnosis, or treatment. The health information contained herein is provided for general educational purposes only. Your healthcare professional is the best source of information regarding your health. Please consult your healthcare professional if you have any questions about your health or treatment.

In this episode our hosts Jason Yeh, PharmD (US Transplant MSL) and Katie McMurry, PharmD (US Transplant MSL) have a conversation with Dr. Sagar Patel, an Assistant Professor in the Transplant and Cellular Therapy Program at the Huntsman Cancer Institute in Salt Lake City, Utah. In this episode, Dr. Patel discusses current transplantation barriers observed in the diagnosis and treatment of chronic graft versus host disease, the existing tools utilized to improve outcomes and potential innovations to mitigate barriers.  

This program is non-promotional and sponsored by Sanofi. Presenter(s) were compensated and/or received an honorarium from Sanofi in connection with this program. This program does not constitute an endorsement by Sanofi of any particular organization or its programming. Additional resources and information may be available and should be investigated.

This podcast is intended for US residents only. Sanofi does not provide medical advice, diagnosis, or treatment. The health information contained herein is provided for general educational purposes only. Your healthcare professional is the best source of information regarding your health. Please consult your healthcare professional if you have any questions about your health or treatment.

In this episode our MSL co-hosts Yiota Manolopoulos, PharmD, MPH and Katie Mousavi, PharmD have a conversation with Anne Peters, MD on how to incorporate social determinants of health in clinical trials and methods to overcome the challenges that under resourced communities face daily. Dr. Peters identifies key barriers that physicians and other healthcare providers encounter when designing clinical trials for patients with diabetes, particularly among racial and ethnic minority populations and other marginalized communities. We conclude the episode with concrete actions and resources our listeners can use to design clinical trials, ensure longevity of these interventions, and begin to narrow the gap on healthcare disparities within the racial and ethnic minority populations with diabetes.   

This program is non-promotional and sponsored by Sanofi. The presenter was compensated by Sanofi in connection with this program. This program does not constitute an endorsement by Sanofi of any particular organization or its programming.  Additional resources and information may be available and should be investigated.

Supporting literature from episode: 

1. Social Determinants of Health at CDC: https://www.cdc.gov/about/sdoh/index.html
2. Social Determinants of Health and Diabetes: A Scientific Review:  https://doi.org/10.2337/dci20-0053 
3. The multidisciplinary team in diagnosing and treatment of patients with diabetes and comorbidities: A scoping review: https://doi.org/10.1177/26335565231165966 

Music: Spark of Inspiration by Shane Ivers - https://www.silvermansound.com  

This program is non-promotional and sponsored by Sanofi. Presenter(s) were compensated and/or received an honorarium from Sanofi in connection with this program. This program does not constitute an endorsement by Sanofi of any particular organization or its programming. Additional resources and information may be available and should be investigated.

This podcast is intended for US residents only. Sanofi does not provide medical advice, diagnosis, or treatment. The health information contained herein is provided for general educational purposes only. Your healthcare professional is the best source of information regarding your health. Please consult your healthcare professional if you have any questions about your health or treatment.

In this episode our hosts Sara Hammad, PharmD (US Transplant Associate Medical Director) and Ryan Bookout, PharmD (US Transplant MSL) have a conversation with Dr. Joseph Scalea, MD. Dr. Scalea is the inaugural Vice Chair of Innovation in the Department of Surgery, the Surgical Director of Kidney Transplant, and the Director of Hepatology, Nephrology, and Transplant ICCE Quality and Innovation at the Medical University of South Carolina. Dr. Scalea will take us through the past, present, and future of how innovation has and can help bridge the disparities gap seen in kidney transplantation today.

Music: Spark of Inspiration by Shane Ivers - https://www.silvermansound.com 

MAT-US-2306343 (v1.0). Approved for Distribution. Exp: 08-02-2025.

This program is non-promotional and sponsored by Sanofi. Presenter(s) were compensated and/or received an honorarium from Sanofi in connection with this program. This program does not constitute an endorsement by Sanofi of any particular organization or its programming. Additional resources and information may be available and should be investigated.

This podcast is intended for US residents only. Sanofi does not provide medical advice, diagnosis, or treatment. The health information contained herein is provided for general educational purposes only. Your healthcare professional is the best source of information regarding your health. Please consult your healthcare professional if you have any questions about your health or treatment.

Join our Sanofi Medical co-hosts, Dalila Masic, Amulya Tatachar and Sara Hammad as we sit down with Subarna Malakar, Head of Diversity, Equity & Inclusion (DE&I) North America and Global Specialty Care at Sanofi. In this episode, Subarna speaks to personal experiences that relate to his passion for health equity. We also discuss Sanofi’s approach to DE&I, and Subarna’s role in leading these initiatives. 

Link to A Million Conversations: https://www.sanofi.com/en/our-company/social-impact/diversity-equity-and-inclusion-in-and-beyond-the-workplace/a-million-conversations

Music: Spark of Inspiration by Shane Ivers - https://www.silvermansound.com 

This program is non-promotional and sponsored by Sanofi. Presenter(s) were compensated and/or received an honorarium from Sanofi in connection with this program. This program does not constitute an endorsement by Sanofi of any particular organization or its programming. Additional resources and information may be available and should be investigated.

This podcast is intended for US residents only. Sanofi does not provide medical advice, diagnosis, or treatment. The health information contained herein is provided for general educational purposes only. Your healthcare professional is the best source of information regarding your health. Please consult your healthcare professional if you have any questions about your health or treatment.

In this episode our co-hosts Sara Hammad, PharmD (US Transplant Associate Medical Director) and Tracy Chen, PharmD (US Transplant Senior MSL) have a conversation with Sumit Mohan, MD, MPH, a Professor of Medicine and Epidemiology at the Columbia University Medical Center, about disparities seen throughout the kidney transplant process. Dr. Mohan discusses the challenges seen with health disparities at all time points from a patient’s journey through kidney transplantation, and ways we could potentially overcome these disparities as a kidney transplant community.  

Music: Spark of Inspiration by Shane Ivers - https://www.silvermansound.com

Supporting literature and resources:  

1. “Early Effect of the Circular Model of Kidney Allocation in the United States” https://pubmed.ncbi.nlm.nih.gov/36302599/ 
2. “Major Variation across Local Transplant Centers in Probability of Kidney Transplant for Wait-Listed Patients” https://pubmed.ncbi.nlm.nih.gov/33037131/ 
3. “Greater complexity and monitoring of the new Kidney Allocation System: Implications and unintended consequences of concentric circle kidney allocation on network complexity” https://pubmed.ncbi.nlm.nih.gov/33314637/ 

MAT-US-2304542 (v1.0)-P Approved for Distribution. Exp: 06-08-2025

This program is non-promotional and sponsored by Sanofi. Presenter(s) were compensated and/or received an honorarium from Sanofi in connection with this program. This program does not constitute an endorsement by Sanofi of any particular organization or its programming. Additional resources and information may be available and should be investigated.

This podcast is intended for US residents only. Sanofi does not provide medical advice, diagnosis, or treatment. The health information contained herein is provided for general educational purposes only. Your healthcare professional is the best source of information regarding your health. Please consult your healthcare professional if you have any questions about your health or treatment.

Join our Medical Science Liaison co-hosts, Amulya Tatachar and Erin Moline, and expert Dr. David Kerr, MBChB DM, FRCP, Director of Digital Health at the Diabetes Technology Society. Dr. Kerr will share more about democratization and discuss the importance of empowering people with diabetes through technology. In this episode, we will continue to build our conversation on trust and add this critical aspect of addressing health disparities – equitable access to technology.

Supporting Literature

• Kerr D et al. A Roadmap to an Equitable Digital Diabetes Ecosystem - Endocrine Practice. Endocrine Practice. 2023;29(3):179-184.
• Kerr D et al. New Digital Health Technologies for Insulin Initiation and Optimization for People With Type 2 Diabetes. Endocrine Practice. 2022;28(8):811-821.
• Kerr D, et al. A persisting parallel universe in diabetes care within America's capital - eClinicalMedicine. The Lancet Discovery Science.2022;43. https://doi.org/10.1016/j.eclinm.2021.101244.
• Kerr D, et al. Dysglycemia in adults at risk for or living with non-insulin treated type 2 diabetes: Insights from continuous glucose monitoring - eClinicalMedicine. The Lancet Discovery Science. 2021;35. https://doi.org/10.1016/j.eclinm.2021.100853
• Kerr D, et al. The northeast glucose drift: Stratification of post-breakfast dysglycemia among predominantly Hispanic/Latino adults at-risk or with type 2 diabetes - eClinicalMedicine. The Lancet Discovery Science. 2022;43. https://doi.org/10.1016/j.eclinm.2021.100853.

This program is non-promotional and sponsored by Sanofi. Presenter(s) were compensated and/or received an honorarium from Sanofi in connection with this program. This program does not constitute an endorsement by Sanofi of any particular organization or its programming. Additional resources and information may be available and should be investigated.

This podcast is intended for US residents only. Sanofi does not provide medical advice, diagnosis, or treatment. The health information contained herein is provided for general educational purposes only. Your healthcare professional is the best source of information regarding your health. Please consult your healthcare professional if you have any questions about your health or treatment.