Ketamine therapy has emerged as a groundbreaking treatment for severe mental health conditions, such as treatment-resistant depression, PTSD, and suicidal ideation. Originally developed as an anesthetic in the 1960s, ketamine's rebranding into a medical intervention has been driven by decades of research demonstrating its rapid-acting and transformative effects. With the recent FDA approval of Johnson & Johnson's ketamine-based nasal spray, Spravato, the therapy has gained mainstream acceptance, offering hope to those who have not found relief with traditional treatments. Despite challenges related to accessibility, cost, and long-term safety, ketamine therapy continues to revolutionize mental health care. The article explores its historical development, current applications, and future potential, while addressing societal, ethical, and cultural implications of this innovative treatment.