Dr. Ben Synth traces ketamine's remarkable 60+ year journey from its 1962 discovery as a battlefield anesthetic to its 2025 FDA approval as a breakthrough depression treatment. This episode explores how a substance once dismissed as a "party drug" became one of the most significant psychiatric innovations of the 21st century, examining the science behind its rapid-acting antidepressant effects and the clinical trials that proved its effectiveness for treatment-resistant depression.

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