This episode reviews clinical management of gastrointestinal symptoms associated with semaglutide therapy and strategies to maintain treatment when intolerance occurs. The discussion explains the role of delayed gastric emptying in nausea and highlights practical approaches including dietary modification, slower dose titration, and symptom directed therapy.
Additional topics include pregnancy planning with the recommended 8 week washout period before conception and emerging evidence for kidney protection from the SUSTAIN 6 and FLOW trials demonstrating reduction in nephropathy progression and cardiovascular events in patients with type 2 diabetes.