Hey college sports fans, it’s clear that 2025’s Clemson vs. South Carolina football game will hang largely on the battle between Tigers QB Cade Klubnik’s efficiency and Gamecocks QB Lanorris Sellers’ ability to run. But several other matchups on the field Saturday in this nook kickoff of the Palmetto Bowl also loom as major factors. Can Antonio Williams lead the Clemson wide receivers to put up big yards-after-catch totals and key the Tigers offense? Can running backs Adam Randall and Gideon Davidson break free despite an injury-depleted Tigers offensive line? Will Clemson’s defensive line find a way to keep Sellers contained and off his game? And can the troubled Tigers defensive backs resolve their problems against a capable Gamecocks receiving corps? Get ready to run through all of it.