In this episode, we take a deeper look at the mechanism behind IgA nephropathy — a condition driven by a defective immune protein (IgA1) that originates in the gut.
We also examine how treatments like Tarpeyo are designed to target immune activity in the small intestine — and why that raises a critical, often overlooked question: what’s activating the immune system there in the first place?
We explore the role of the gut microbiome, chronic infections, and mucosal immune triggers in driving abnormal IgA responses. From oral and tonsil-related infections to gut imbalances and pathogens like Helicobacter pylori, emerging research suggests these upstream factors may play a meaningful role in how the disease develops and progresses.
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