n this episode of The Gazette of Medical Sciences Podcast, we dive into a compelling case report by Dr. Zaibun Nisa, Consultant Histopathologist at Queen’s Hospital, Romford, Barking, Havering, and Redbridge NHS Trust. The study explores the rare and intricate challenge of differentiating between primary bladder adenocarcinoma and metastatic colorectal cancer using KRAS mutations.

This fascinating case involves an elderly patient whose unexpected bladder involvement was eventually linked to metastatic colorectal cancer, thanks to molecular analysis revealing a KRAS mutation. Dr. Nisa's insightful findings highlight how advanced diagnostics, including histology, immunohistochemistry, and molecular testing, can lead to definitive diagnoses in complex oncological cases.

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