A real area game changer started January 7th, 2019. Any guesses? This past Monday, January 7th, Sky West Airlines began offering three flights a day to Chicago O’Hare International Airport from the Cape Girardeau Regional Airport. Departures are at approximately 6:00 a.m., 12:00 noon, and 4:00 p.m. with return flights at approximately 11:30 a.m., 3:30 p.m., and 11:45 p.m. Monday through Friday. The early morning and late afternoon flight have one stop in Paducah, Kentucky, and the mid-day flight