Lagrange Point

Lagrange Point

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Lagrange Point episodes

  • Episode 467 - Repairing throats and better implants

    How can we make stronger implants that don't get rejected by the body? Bioactive materials can help make implants feel more at home. Replacing a knee or a hip requires not just strength but also compatibility. A new coating method makes it easier for implants to fit in. An implant has to be strong yet flexible, friendly to cells but not bacteria - it's challenging. Your vocal chords are subject to extreme forces, so how can we design an implant to repair them? Hydro-gels can help repair damaged organs and tissue even in extreme environments like your vocal chods.

    1. Imran Deen, Gurpreet Singh Selopal, Zhiming M. Wang, Federico Rosei. Electrophoretic deposition of collagen/chitosan films with copper-doped phosphate glasses for orthopaedic implants. Journal of Colloid and Interface Science, 2022; 607: 869 DOI: 10.1016/j.jcis.2021.08.199
  • Sareh Taheri, Guangyu Bao, Zixin He, Sepideh Mohammadi, Hossein Ravanbakhsh, Larry Lessard, Jianyu Li, Luc Mongeau. Injectable, Pore‐Forming, Perfusable Double‐Network Hydrogels Resilient to Extreme Biomechanical Stimulations. Advanced Science, 2021; 2102627 DOI: 10.1002/advs.202102627
  • 17 min
  • Episode 466 - Tsunamis, underwater volcanoes and magnetic fields

    When Tsunami's strike, every extra minute of notice can help save lives. How can scientists better predict the height and journey of a tsunami? We look at the ways scientists can use tectonic plates or magnetic fields to improve tsunami predictions. Where an earthquake occurs can make a big difference to the size of a tsunami. The shallower an earthquake in a thinner sub-ducting plate can lead to higher tsunamis. When you move a large amount of sea-water the earths magnetic field changes, just enough to detect. Like reading the vibrations in seismic waves, earth's magnetic field changes enough for you to identify a tsunami. Using magnetic fields you can measure and asses the height of a tsunami much faster.

    1. Zhiheng Lin, Hiroaki Toh, Takuto Minami. Direct Comparison of the Tsunami‐Generated Magnetic Field With Sea Level Change for the 2009 Samoa and 2010 Chile Tsunamis. Journal of Geophysical Research: Solid Earth, 2021; 126 (11) DOI: 10.1029/2021JB022760
  • Kwok Fai Cheung, Thorne Lay, Lin Sun, Yoshiki Yamazaki. Tsunami size variability with rupture depth. Nature Geoscience, 2021; DOI: 10.1038/s41561-021-00869-z
  • 18 min
  • Episode 465 - Hedgehogs to mouthwash - Strange tales of the war against bacteria

    From Hedgehogs to mouthwash, we check in on the arms race against bacteria. MRSA super-bugs are a super problem for humans, but some pre-date the modern era. MRSA super-bugs have been around since the Industrial revolution, at least on hedgehogs. The skin of hedgehogs is a battlefield between Fungus and Bacteria, and whoever wins, we loose. We often focus on Humans vs Bacteria, but it's actually a triple threat with Fungus. The fight Fungus vs Bacteria can lead to the development of antibiotic resistance. The mouth is the gate in the castle like defenses of the human immune system, so what defends it from bacteria attackers? If you have periodontal disease, it can make it easier for other viruses to get into your body. Keeping your mouth free of bacteria plaque can keep your defense against other infections high.

    1. Jesper Larsen, Claire L. Raisen, Xiaoliang Ba, Nicholas J. Sadgrove, Guillermo F. Padilla-González, Monique S. J. Simmonds, Igor Loncaric, Heidrun Kerschner, Petra Apfalter, Rainer Hartl, Ariane Deplano, Stien Vandendriessche, Barbora Černá Bolfíková, Pavel Hulva, Maiken C. Arendrup, Rasmus K. Hare, Céline Barnadas, Marc Stegger, Raphael N. Sieber, Robert L. Skov, Andreas Petersen, Øystein Angen, Sophie L. Rasmussen, Carmen Espinosa-Gongora, Frank M. Aarestrup, Laura J. Lindholm, Suvi M. Nykäsenoja, Frederic Laurent, Karsten Becker, Birgit Walther, Corinna Kehrenberg, Christiane Cuny, Franziska Layer, Guido Werner, Wolfgang Witte, Ivonne Stamm, Paolo Moroni, Hannah J. Jørgensen, Hermínia de Lencastre, Emilia Cercenado, Fernando García-Garrote, Stefan Börjesson, Sara Hæggman, Vincent Perreten, Christopher J. Teale, Andrew S. Waller, Bruno Pichon, Martin D. Curran, Matthew J. Ellington, John J. Welch, Sharon J. Peacock, David J. Seilly, Fiona J. E. Morgan, Julian Parkhill, Nazreen F. Hadjirin, Jodi A. Lindsay, Matthew T. G. Holden, Giles F. Edwards, Geoffrey Foster, Gavin K. Paterson, Xavier Didelot, Mark A. Holmes, Ewan M. Harrison, Anders R. Larsen. Emergence of methicillin resistance predates the clinical use of antibiotics. Nature, 2022; DOI: 10.1038/s41586-021-04265-w
  • Carlos J. Rodriguez-Hernandez, Kevin J. Sokoloski, Kendall S. Stocke, Himabindu Dukka, Shunying Jin, Melissa A. Metzler, Konstantin Zaitsev, Boris Shpak, Daonan Shen, Daniel P. Miller, Maxim N. Artyomov, Richard J. Lamont, Juhi Bagaitkar. Microbiome-mediated incapacitation of interferon lambda production in the oral mucosa. Proceedings of the National Academy of Sciences, 2021; 118 (51): e2105170118 DOI: 10.1073/pnas.2105170118
  • 14 min
  • Episode 464 - Rogue Planets and glass in meteorites

    Rogue planets hurtling across space without a place to call home. How do we detect intergalactic nomads like Rogue planets? Just how many rogue planets are out there? Are there rogue planets lurking in our own solar system? Glass inside meteorites can help us understand early earth. How does meteorite rock differ from rock here on earth? What can we piece together about the cataclysmic events that formed glass inside meteorites? Rapidly heating then even more rapidly cooling coalesced glass inside meteorites.

    1. Núria Miret-Roig, Hervé Bouy, Sean N. Raymond, Motohide Tamura, Emmanuel Bertin, David Barrado, Javier Olivares, Phillip A. B. Galli, Jean-Charles Cuillandre, Luis Manuel Sarro, Angel Berihuete, Nuria Huélamo. A rich population of free-floating planets in the Upper Scorpius young stellar association. Nature Astronomy, 2021; DOI: 10.1038/s41550-021-01513-x
  • Nicole X. Nie, Xin-Yang Chen, Timo Hopp, Justin Y. Hu, Zhe J. Zhang, Fang-Zhen Teng, Anat Shahar, Nicolas Dauphas. Imprint of chondrule formation on the K and Rb isotopic compositions of carbonaceous meteorites. Science Advances, 2021; 7 (49) DOI: 10.1126/sciadv.abl3929
  • 19 min
  • Episode 463 - Unlocking former junk DNA in Rice to feed the planet

    How was rice turned from a wild grass into a staple crop for over 3 billion people? What secrets are lurking in the 'junk' DNA of rice that can explain it's transformation? What parts of the rice genome have been long overlooked? Can non protein coding parts of a genome help define important traits for plants and animals? Proteins aren't everything; unlocking the secrets of the rice genome.  How can we boost rice yields and rice bran oil content?

    1. X. M. Zheng, J. Chen, H. B. Pang, S. Liu, Q. Gao, J. R. Wang, W. H. Qiao, H. Wang, J. Liu, K. M. Olsen, and Q. W. Yang. Genome-wide analyses reveal the role of noncoding variation in complex traits during rice domestication. Science Advances, 2019 DOI: 10.1126/sciadv.aax3619
  • Ze‐Hua Guo, Richard P. Haslam, Louise V Michaelson, Edward C. Yeung, Shiu‐Cheung Lung, Johnathan A. Napier, Mee‐Len Chye. The overexpression of rice ACYL ‐ CoA ‐ BINDING PROTEIN 2 increases grain size and bran oil content in transgenic rice. The Plant Journal, 2019; 100 (6): 1132 DOI: 10.1111/tpj.14503
  • 15 min
  • Episode 462 - Fish helping make smart materials and renewable tech

    What can fish scales teach us about the next generation of smart materials. Why is 'scale armor' often found in video games and on fish so strong? What is special about fish scales that can help us make a new generation of smart materials for clothing and structures? What do 35 million year old fish trapped in mud have to do with wind turbines and batteries? Renewable tech relies on Rare earth metals, so where do we find them? Studying fossilized fish can help us find more sources of rare earth metals to build more renewable tech.

    1. Haocheng Quan, Wen Yang, Marine Lapeyriere, Eric Schaible, Robert O. Ritchie, Marc A. Meyers. Structure and Mechanical Adaptability of a Modern Elasmoid Fish Scale from the Common Carp. Matter, 2020; DOI: 10.1016/j.matt.2020.05.011
  • Junichiro Ohta, Kazutaka Yasukawa, Tatsuo Nozaki, Yutaro Takaya, Kazuhide Mimura, Koichiro Fujinaga, Kentaro Nakamura, Yoichi Usui, Jun-Ichi Kimura, Qing Chang, Yasuhiro Kato. Fish proliferation and rare-earth deposition by topographically induced upwelling at the late Eocene cooling event. Scientific Reports, 2020; 10 (1) DOI: 10.1038/s41598-020-66835-8
  • 17 min
  • Episode 461 - What trees can help save a city

    Planting trees can help save the planet, but which trees should you plant? How do you decide what trees to plant and where to help the environment and people? Trees can help reduce pollution in the air and ground, so where are they most effective in a city? Planting urban trees can have significant public health benefits, but what trees are most effective to plant? Just what exactly is grass? How can detailed modeling and genetic testing help solve the riddle of grass classification? Are grass leaves and sheathes one thing, or is it stem and leaf like a tree?

    1. A. E. Richardson, J. Cheng, R. Johnston, R. Kennaway, B. R. Conlon, A. B. Rebocho, H. Kong, M. J. Scanlon, S. Hake, E. Coen. Evolution of the grass leaf by primordium extension and petiole-lamina remodeling. Science, 2021; 374 (6573): 1377 DOI: 10.1126/science.abf9407
  • Loren P. Hopkins, Deborah J. January‐Bevers, Erin K. Caton, Laura A. Campos. A simple tree planting framework to improve climate, air pollution, health, and urban heat in vulnerable locations using non‐traditional partners. PLANTS, PEOPLE, PLANET, 2021; DOI: 10.1002/ppp3.10245
  • 18 min
  • Episode 460 - What shape is the heliosphere

    Just what is the heliosphere and how doe sit work? What shape is the heliosphere (spoiler alert, probably not a sphere). At the very edge of our solar system lies the boundary between our neighborhood and interstellar space. Do outside forces from interstellar space jumble up the heliosphere? Sandwiched between Space and the Earth, the Ionsphere buzzes and hums with a pulsing generator. Winds from earth can bend and shape plasma in our ionsphere to make a generator. Moving a conducting object through a magnetic field can generate electricty, and its happening right now 100km above our heads.

    1. M. Opher, J. F. Drake, G. Zank, E. Powell, W. Shelley, M. Kornbleuth, V. Florinski, V. Izmodenov, J. Giacalone, S. Fuselier, K. Dialynas, A. Loeb, J. Richardson. A Turbulent Heliosheath Driven by the Rayleigh–Taylor Instability. The Astrophysical Journal, 2021; 922 (2): 181 DOI: 10.3847/1538-4357/ac2d2e
  • Thomas J. Immel, Brian J. Harding, Roderick A. Heelis, Astrid Maute, Jeffrey M. Forbes, Scott L. England, Stephen B. Mende, Christoph R. Englert, Russell A. Stoneback, Kenneth Marr, John M. Harlander, Jonathan J. Makela. Regulation of ionospheric plasma velocities by thermospheric winds. Nature Geoscience, 2021; DOI: 10.1038/s41561-021-00848-4
  • 20 min
  • Episode 459 - Bees that eat meat, and Ants with a social stomach

    Bees seem friendly and sweet, but what about a bee that eats meat? What has to happen to allow a bee to consume meat instead of pollen. What does honey produced by meat eating bees taste like? How do meat eating bees bite into their food? How different is the stomach of a meat eating bee from it's vegetarian cousins?Forget photos of food on social networks, ants have a whole social stomach for exchanging proteins. Ants carry and exchange all sorts of fluids to help parts of the colony at the right time. Ants second stomach does not contain food but is used to help process fluids for the colony.

    1. Laura L. Figueroa, Jessica J. Maccaro, Erin Krichilsky, Douglas Yanega, Quinn S. McFrederick. Why Did the Bee Eat the Chicken? Symbiont Gain, Loss, and Retention in the Vulture Bee Microbiome. mBio, 2021; DOI: 10.1128/mBio.02317-21
  • Sanja M Hakala, Marie-Pierre Meurville, Michael Stumpe, Adria C LeBoeuf. Biomarkers in a socially exchanged fluid reflect colony maturity, behavior and distributed metabolism. eLife, 2021; 10 DOI: 10.7554/eLife.74005
  • 18 min
  • Episode 458 - Molecular methods to fight fungi and bacteria

    There's a public health crisis looming beyond the pandemic. Researchers across the world are working to stop the next public health disaster - the rise of antibiotic resistance. We rely on antibiotics to treat various disease but their effectiveness wanes as bacteria builds its resistance. How do we keep track of the changes in bacteria's resistance to antibiotics? What do bird droppings in Cambridge tell us about antibiotic resistance? Developing new antibiotics is tricky, what part of bacteria do you target? Is it better to have a simple molecule or a complex one when tackling bacteria? Bursting the bacteria cell is one way to defeat but its even better to break their building blocks. Fungal infections are growing more resistant to treatment. How can we devleop new categories of anti-fungal treatments?

    References

    1. Joana G. C. Rodrigues, Harisree P. Nair, Christopher O'Kane, Caray A. Walker. Prevalence of multidrug resistance in Pseudomonas spp. isolated from wild bird feces in an urban aquatic environment. Ecology and Evolution, 2021; 11 (20): 14303 DOI: 10.1002/ece3.8146
  • Elisabeth Reithuber, Torbjörn Wixe, Kevin C. Ludwig, Anna Müller, Hanna Uvell, Fabian Grein, Anders E. G. Lindgren, Sandra Muschiol, Priyanka Nannapaneni, Anna Eriksson, Tanja Schneider, Staffan Normark, Birgitta Henriques-Normark, Fredrik Almqvist, Peter Mellroth. THCz: Small molecules with antimicrobial activity that block cell wall lipid intermediates. Proceedings of the National Academy of Sciences, 2021; 118 (47): e2108244118 DOI: 10.1073/pnas.2108244118
  • Christian DeJarnette, Chris J. Meyer, Alexander R. Jenner, Arielle Butts, Tracy Peters, Martin N. Cheramie, Gregory A. Phelps, Nicole A. Vita, Victoria C. Loudon-Hossler, Richard E. Lee, Glen E. Palmer. Identification of Inhibitors of Fungal Fatty Acid Biosynthesis. ACS Infectious Diseases, 2021; DOI: 10.1021/acsinfecdis.1c00404
  • 19 min

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A fun take on the latest science news with enough data to sink your teeth into. Lagrange Point goes beyond the glossy summary and gets in depth with the research from across the world.