Lagrange Point

How can we give better quality of life for those suffering from neurological conditions? Getting a concussion is bad enough, but why do people often develop epilepsy afterwards? What is the link between concussions and epilepsy? How can we effectively reduce the risk of epilepsy after a concussion? For certain epilepsy conditions in children, CBD can help reduce seizure risk, but what type is best? Is pharmaceutical or artisan CBD for children with epilepsy?

1. Akshata A. Korgaonkar, Ying Li, Dipika Sekhar, Deepak Subramanian, Jenieve Guevarra, Bogumila Swietek, Alexandra Pallottie, Sukwinder Singh, Kruthi Kella, Stella Elkabes, Vijayalakshmi Santhakumar. Toll‐like Receptor 4 Signaling in Neurons Enhances Calcium‐Permeable α‐Amino‐3‐Hydroxy‐5‐Methyl‐4‐Isoxazolepropionic Acid Receptor Currents and Drives Post‐Traumatic Epileptogenesis. Annals of Neurology, 2020; DOI: 10.1002/ana.25698

Making chemistry green and sustainable, from cheaper catalyst to sorting solvents. How can you make catalysts cheaper and re-usable? Is there a cheaper catalyst to breakdown CO2? How can we make a circular carbon economy? Solvents play an important role in chemistry so how do you greenly find the right match? Green chemistry can be made more efficient using CO2.

1. Youngdong Song, Ercan Ozdemir, Sreerangappa Ramesh, Aldiar Adishev, Saravanan Subramanian, Aadesh Harale, Mohammed Albuali, Bandar Abdullah Fadhel, Aqil Jamal, Dohyun Moon, Sun Hee Choi, Cafer T. Yavuz. Dry reforming of methane by stable Ni–Mo nanocatalysts on single-crystalline MgO. Science, 2020; 367 (6479): 777 DOI: 10.1126/science.aav2412

What happens when stars brawl? What do they leave behind? When stars are dying they take down everything and everything around them from asteroids to other stars. What is the YORP effect? How do some tiny solar particles destroy an asteroid? Spiraling out of control, asteroids get YORP-ed at the end of a star's life. When a star gets to the end of it's life, it may swell in size, taking out asteroids and nearby stars.

1. H. Olofsson, T. Khouri, M. Maercker, P. Bergman, L. Doan, D. Tafoya, W. H. T. Vlemmings, E. M. L. Humphreys, M. Lindqvist, L. Nyman, S. Ramstedt. HD 101584: circumstellar characteristics and evolutionary status. Astronomy & Astrophysics, 2019; 623: A153 DOI: 10.1051/0004-6361/201834897

From wasps to bees how are insects adapting to a changing world. What type of food do bees prefer? Can a bee be a fussy eater? What makes a tasty meal for a Bee and what would they avoid like the plague? What changes can be introduced into the microbiome by pesticides? How can pesticides change the microbiome of wasps and develop into resistance? Can pesticide actually make lives harder for themselves by building tolerance in insects? How does an Asian hornet end up in Northern Europe?

1. Wang et al. Changes in microbiome confer multigenerational host resistance after sub-toxic pesticide exposure. Cell Host & Microbe, 2020 DOI: 10.1016/j.chom.2020.01.009

The Coronavirus family is a dangerous lot from SARS to MERS and Novel Coronavirus 2019. This week we look at the history of Coronavirus outbreaks, research into past infections and public health strategy. We do some fact checking on Coronavirus myths and fears. What lessons were learnt from the SARS outbreak of '03 that can help today in '20? How can turning off the cells recycling plant stop Coronaviruses in their tracks? What role does cell autophagy play in spreading or stopping MERS? What can we learn from the sequenced genomes of coronaviruses? How can tracking the ACE2 gene help people monitor the mutation of the coronavirus strains?

1. Lewis, D. (2020). Coronavirus outbreak: what’s next? Nature. doi: 10.1038/d41586-020-00236-9

There are mysterious things lurking at the bottom of the ocean, from underwater volcanoes to mysterious graphite. Where did a pumice raft floating across the Pacific come from? Why is a raft of pumice larger than Manhattan heading to Australia? What can we learn by studying petit-spot volcanoes underneath the ocean? What connects young volcanoes with the motion of the tectonic plates? What roll do hydrothermal vents play in the carbon cycle? Where does all this graphite in the oceans come from?

1. Philipp A. Brandl, Florian Schmid, Nico Augustin, Ingo Grevemeyer, Richard J. Arculus, Colin W. Devey, Sven Petersen, Margaret Stewart, Heidrun Kopp, Mark D. Hannington. The 6–8 Aug 2019 eruption of ‘Volcano F’ in the Tofua Arc, Tonga. Journal of Volcanology and Geothermal Research, 2019; 106695 DOI: 10.1016/j.jvolgeores.2019.106695

What happens next after disaster strikes and people flee for safety? How do wildlife move in when people move out of a disaster zone? How do animals moving into an evacuated area change with no humans around? What is the most effective thing to do if you live near a disaster area? How do we assess risk and life expectancy impact of living near a disaster zone? Is it more dangerous to live near a nuclear plant or in the diesel smog of the big city?

1. Phillip C Lyons, Kei Okuda, Matthew T Hamilton, Thomas G Hinton, James C Beasley. Rewilding of Fukushima's human evacuation zone. Frontiers in Ecology and the Environment, 2020; DOI: 10.1002/fee.2149

From Fast Radio Bursts to Cosmic rays, interstellar mystery solving is a team effort. Mysterious repeating signals from space are tricky to localize, like spotting a person on the moon from here on Earth. What can fast radio bursts from billions of light years away tell us about the nature of the universe? How do you hunt for the source of a mysterious radio burst billions of light years away? How does a tiger, a balloon and Antarctica help us understand Supernova? What's the best place to hunt for cosmic rays; floating above Antarctica with a Super Tiger.

1. B. Marcote, K. Nimmo, J. W. T. Hessels, S. P. Tendulkar, C. G. Bassa, Z. Paragi, A. Keimpema, M. Bhardwaj, R. Karuppusamy, V. M. Kaspi, C. J. Law, D. Michilli, K. Aggarwal, B. Andersen, A. M. Archibald, K. Bandura, G. C. Bower, P. J. Boyle, C. Brar, S. Burke-Spolaor, B. J. Butler, T. Cassanelli, P. Chawla, P. Demorest, M. Dobbs, E. Fonseca, U. Giri, D. C. Good, K. Gourdji, A. Josephy, A. Yu. Kirichenko, F. Kirsten, T. L. Landecker, D. Lang, T. J. W. Lazio, D. Z. Li, H.-H. Lin, J. D. Linford, K. Masui, J. Mena-Parra, A. Naidu, C. Ng, C. Patel, U.-L. Pen, Z. Pleunis, M. Rafiei-Ravandi, M. Rahman, A. Renard, P. Scholz, S. R. Siegel, K. M. Smith, I. H. Stairs, K. Vanderlinde, A. V. Zwaniga. A repeating fast radio burst source localized to a nearby spiral galaxy. Nature, 2020; DOI: 10.1038/s41586-019-1866-z

How do we peer into the inner workings of our cells, especially during their response to a medical emergency? What role does fibroblasts play to protect your heart after a heart attack? When is your body hardest at work repairing damage after a heart attack? What stem cells control your blood cells? How can we get a picture of the complex 3D shape of blood stem cells in your bone marrow? What role does bone marrow play in blood regulation?

1. Chiara Baccin, Jude Al-Sabah, Lars Velten, Patrick M. Helbling, Florian Grünschläger, Pablo Hernández-Malmierca, César Nombela-Arrieta, Lars M. Steinmetz, Andreas Trumpp, Simon Haas. Combined single-cell and spatial transcriptomics reveal the molecular, cellular and spatial bone marrow niche organization. Nature Cell Biology, 2019; DOI: 10.1038/s41556-019-0439-6

What can bacteria from an iron ore rich lake tell us about life on early earth? Have scientists finally solved a Carl Sagan paradox about life on early earth? When the earth was young, so was the sun, and that meant less light and heat. How did early life on earth survive if there was not enough sunlight to keep it warm? How did iron ore eating and secreting bacteria help lead to widespread life on our planet? How did micro organisms get enough oxygen to survive when the entire planet was frozen over? What can iron ore deposits tell us about life surviving when the entire planet was frozen over? Can life survive on a meteorite, the answer is surprising. How can a microbe be more suited to life on a meteorite than on earth?

1. Katharine J. Thompson, Paul A. Kenward, Kohen W. Bauer, Tyler Warchola, Tina Gauger, Raul Martinez, Rachel L. Simister, Céline C. Michiels, Marc Llirós, Christopher T. Reinhard, Andreas Kappler, Kurt O. Konhauser, Sean A. Crowe. Photoferrotrophy, deposition of banded iron formations, and methane production in Archean oceans. Science Advances, 2019; 5 (11): eaav2869 DOI: 10.1126/sciadv.aav2869