Lagrange Point

Lagrange Point

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Lagrange Point episodes

  • Episode 506 - Assimilating all microbes in it’s path to chow down on Methane

    How have microbes changed the course of life on our planet? How has our atmosphere changed as a result of bacteria and archaea? Assimilation can help enhance single cellular life. Archaea can collect long strings of extra genes just in case. Finding the right gene at the right moment can help Archaea make the most of available food.

    1. Basem Al-Shayeb, Marie C. Schoelmerich, Jacob West-Roberts, Luis E. Valentin-Alvarado, Rohan Sachdeva, Susan Mullen, Alexander Crits-Christoph, Michael J. Wilkins, Kenneth H. Williams, Jennifer A. Doudna, Jillian F. Banfield. Borgs are giant genetic elements with potential to expand metabolic capacity. Nature, 2022; DOI: 10.1038/s41586-022-05256-1
    16 min
  • Episode 505 - Complex ocean currents sustaining life across the depths

    Ocean currents can have global impacts shaping our climate and life in the seas and onshore. How do the ocean currents circulate and vary not just on the surface but beneath the waves? It's easy to picture different layers of clouds, but the same is true for our oceans. Large circulating patterns of currents called Gyres govern the oceans. Tiny phytoplankton keep our oceans alive but how do they get enough food themselves? The middle of a gyre gets baked in sun and seems to lack nutrient sources, so how do microbes survive there? When phytoplankton die they rain down nutrients and carbon to lower layers of the ocean as marine snow.

    1. Mukund Gupta, Richard G. Williams, Jonathan M. Lauderdale, Oliver Jahn, Christopher Hill, Stephanie Dutkiewicz, Michael J. Follows. A nutrient relay sustains subtropical ocean productivity. Proceedings of the National Academy of Sciences, 2022; 119 (41) DOI: 10.1073/pnas.2206504119
    16 min
  • Episode 504 - Looking inside living cells with Bioorthogonal chemistry

    A big prize like the Nobel for Chemistry doesn't appear out of nowhere. To win a Nobel Prize, a lot of team work in laboratories and across the world has to come together. We find out about the research that led towards the Nobel Prize for chemistry and how it grew. How does Click Chemistry solve the problem of messy and complicated reactions? How do you look inside a cell when it's working without destroying it? How can you get precise tracking of cells behavior using Bioorthogonal chemistry.

    1. Castelvecchi, D. and Ledford, H., 2022. Chemists who invented revolutionary ‘click’ reactions win Nobel. [online] Nature.com. Available at: [Accessed 8 October 2022].
  • Ramström, O., 2022. CLICK CHEMISTRY A N D BIOORTHOGONAL CHEMISTRY. [online] Nobelprize.org. Available at: [Accessed 8 October 2022].
  • Zhang, H., 2022. Nobel Prize: How click chemistry and bioorthogonal chemistry are transforming the pharmaceutical and material industries. [online] The Conversation. Available at: [Accessed 8 October 2022].
  • 19 min
  • Episode 502 - Ignobel prizes ’22 - Blind dates and Mother Ducks

    We celebrate the Ignobel prizes for 2022 with science that makes you laugh and then think. What connects a Fish, ducks and slipstream racing? How do mother ducks manage to keep all their ducklings in tow? Does swimming in formation help the ducks save energy? What's the best spot in the slipstream to be? We all know following in the slipstream is good, but if you're 3 or more back you can literally get pulled along. Complex fluid mechanics makes swimming in a line a way for a mother duck to pull the ducklings along. What happens physically when you find someone who is a good match? Is eye contact or heart rate a better measure of having  a 'spark' with someone new?

    1. Wave-Riding and Wave-Passing by Ducklings in Formation Swimming,” Zhi-Ming Yuan, Minglu Chen, Laibing Jia, Chunyan Ji, and Atilla Incecik, Journal of Fluid Mechanics, vol. 928, no. R2, 2021.
  • “Energy Conservation by Formation Swimming: Metabolic Evidence from Ducklings,” Frank E. Fish, in the book Mechanics and Physiology of Animal Swimming, 1994, pp. 193-204.
  • Physiological Synchrony is Associated with Attraction in a Blind Date Setting,” Eliska Prochazkova, Elio Sjak-Shie, Friederike Behrens, Daniel Lindh, and Mariska E. Kret, Nature Human Behaviour, vol. 6, no. 2, 2022, pp. 269-278.
  • 15 min
  • Episode 502 - Ignobel prizes ’22 - Blind dates and Mother Ducks

    We celebrate the Ignobel prizes for 2022 with science that makes you laugh and then think. What connects a Fish, ducks and slipstream racing? How do mother ducks manage to keep all their ducklings in tow? Does swimming in formation help the ducks save energy? What's the best spot in the slipstream to be? We all know following in the slipstream is good, but if you're 3 or more back you can literally get pulled along. Complex fluid mechanics makes swimming in a line a way for a mother duck to pull the ducklings along. What happens physically when you find someone who is a good match? Is eye contact or heart rate a better measure of having  a 'spark' with someone new?

    1. Wave-Riding and Wave-Passing by Ducklings in Formation Swimming,” Zhi-Ming Yuan, Minglu Chen, Laibing Jia, Chunyan Ji, and Atilla Incecik, Journal of Fluid Mechanics, vol. 928, no. R2, 2021.
  • “Energy Conservation by Formation Swimming: Metabolic Evidence from Ducklings,” Frank E. Fish, in the book Mechanics and Physiology of Animal Swimming, 1994, pp. 193-204.
  • Physiological Synchrony is Associated with Attraction in a Blind Date Setting,” Eliska Prochazkova, Elio Sjak-Shie, Friederike Behrens, Daniel Lindh, and Mariska E. Kret, Nature Human Behaviour, vol. 6, no. 2, 2022, pp. 269-278.
  • 15 min
  • Episode 501 - The journey of the mandarin

    Mandarin oranges are very closely related but also incredibly diverse. A quirk of cloning means we can accurately trace the journey of all mandarins back to their origins in Hunan province. Mandarins come in so many shapes and sizes and are used to celebrate by many cultures, but they all share a lot in common. Oregano and Thyme both produce some great smells, but these chemicals can carry a useful punch. How do Oregano and Thyme produce chemicals with antibacterial properties?

    1. Sandra T. Krause, Pan Liao, Christoph Crocoll, Benoît Boachon, Christiane Förster, Franziska Leidecker, Natalie Wiese, Dongyan Zhao, Joshua C. Wood, C. Robin Buell, Jonathan Gershenzon, Natalia Dudareva, Jörg Degenhardt. The biosynthesis of thymol, carvacrol, and thymohydroquinone in Lamiaceae proceeds via cytochrome P450s and a short-chain dehydrogenase. Proceedings of the National Academy of Sciences, 2021; 118 (52): e2110092118 DOI: 10.1073/pnas.2110092118
  • Guohong Albert Wu, Chikatoshi Sugimoto, Hideyasu Kinjo, Chika Azama, Fumimasa Mitsube, Manuel Talon, Frederick G. Gmitter, Daniel S. Rokhsar. Diversification of mandarin citrus by hybrid speciation and apomixis. Nature Communications, 2021; 12 (1) DOI: 10.1038/s41467-021-24653-0
  • 18 min
  • Episode 500 - Forest helping pump water and create rain

    Plants harness the energy from the sun for so much more than photosynthesis. You have a beating hart to pump around your blood, but what do plants. Plants' vascular systems aren't pressurized so how do they power their circulation? Just how much energy do plants use globally each year to pump water out of the ground and into their leaves? Plants use incredible amounts of energy each year just to pump water out of the ground into their leaves. The fresh scents of plants are organic compounds that can reveal a lot about a plants condition. The scents of plants can play a role in influencing the climate around them. 

    1. Gregory R. Quetin, Leander D. L. Anderegg, Alexandra G. Konings, Anna T. Trugman. Quantifying the Global Power Needed for Sap Ascent in Plants. Journal of Geophysical Research: Biogeosciences, 2022; 127 (8) DOI: 10.1029/2022JG006922
  • Joseph Byron, Juergen Kreuzwieser, Gemma Purser, Joost van Haren, S. Nemiah Ladd, Laura K. Meredith, Christiane Werner, Jonathan Williams. Chiral monoterpenes reveal forest emission mechanisms and drought responses. Nature, 2022; 609 (7926): 307 DOI: 10.1038/s41586-022-05020-5
  • 19 min
  • Episode 499 - Air and atmospheres on exoplanets

    CO2 gets a lot of bad press on earth, but in space, it could actually be incredibly helpful. On Mars, the Perseverance mission turned CO2 into Oxygen just like a tree. Making air on Mars requires a bit of Moxie and Perseverance. Mar's atmosphere may be thin, highly variable and full of CO2 but it can be harnessed to produce Oxygen. Could future mission to Mars make their own oxygen on the surface of Mars? Finding CO2 on exoplanets has been incredibly hard but the JWST helps shed light on this universal gas. Incredible hot, massive but not super dense, the Hot Jupiter WASP-39b becomes the latest target of the JWST. What can a hot Jupiter like WASP-39b teach us about exoplanet formation?

    1. The JWST Transiting Exoplanet Community Early Release Science Team et al. Identification of carbon dioxide in an exoplanet atmosphere. Nature (in press), 2022 [abstract]
  • Jeffrey A. Hoffman, Michael H. Hecht, Donald Rapp, Joseph J. Hartvigsen, Jason G. Soohoo, Asad M. Aboobaker, John B. Mcclean, Andrew M. Liu, Eric D. Hinterman, Nasr, Shravan Hariharan, Kyle J. Horn, Forrest E. Meyen, Harald Okkels, Parker Steen, Singaravelu Elangovan, Christopher R. Graves, Piyush Khopkar, Morten B. Madsen, Gerald E. Voecks, Peter, H. Smith, Theis, L. Skafte, Koorosh R. Araghiand, David J. Eisenman. Mars Oxygen ISRU Experiment (MOXIE)—Preparing for human Mars exploration. Science Advances, 2022 DOI: DOI: 10.1126/sciadv.abp8636
  • 19 min
  • Episode 498 - Proteins, MRNA and fighting back against cancer


    How can we develop new treatments to tackle antibiotic resistance and tumors. Antibiotics were the miracle of public health in the 20th century, but how can we establish new treatments into the 21st. Find the right protein and you can stop bacteria in its tracks by splitting it in two. New treatments can tackle antibiotic resistant bacteria by using proteins to break them in two. Cancer vaccines are benefiting from the mRNA revolution. A challenge with vaccines is that they can end up in the liver, so how do you get them to  deliver their instructions more effectively. Using special lipid nano particles, cancer mRNA vaccines can target the lymph nodes making for more powerful vaccines.

    1. Shouya Feng, Daniel Enosi Tuipulotu, Abhimanu Pandey, Weidong Jing, Cheng Shen, Chinh Ngo, Melkamu B. Tessema, Fei-Ju Li, Daniel Fox, Anukriti Mathur, Anyang Zhao, Runli Wang, Klaus Pfeffer, Daniel Degrandi, Masahiro Yamamoto, Patrick C. Reading, Gaetan Burgio, Si Ming Man. Pathogen-selective killing by guanylate-binding proteins as a molecular mechanism leading to inflammasome signaling. Nature Communications, 2022; 13 (1) DOI: 10.1038/s41467-022-32127-0
  • Jinjin Chen, Zhongfeng Ye, Changfeng Huang, Min Qiu, Donghui Song, Yamin Li, Qiaobing Xu. Lipid nanoparticle-mediated lymph node–targeting delivery of mRNA cancer vaccine elicits robust CD8 + T cell response. Proceedings of the National Academy of Sciences, 2022; 119 (34) DOI: 10.1073/pnas.2207841119
  • 13 min

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A fun take on the latest science news with enough data to sink your teeth into. Lagrange Point goes beyond the glossy summary and gets in depth with the research from across the world.