Limitless Mindset

I’ve done my damndest to break out of my “Nootropics Guy” mold - yet the internet seems to think all I’m good for is answering your Smart Drugs questions! So I’ll oblige, answering the March Biohacking and lifehacking questions...

Disclaimer

What you find here is NOT medical advice. I’m not a doctor. I’m just an experienced, unlicensed self-experimenter practicing free speech by talking about my own extensive experiences and my interpretations of published science. Please see my guide on How to Biohack Smart and Safe. You should consult a doctor about any biohacking you’re doing and, ideally, also get a second opinion.

Q:

love ur videos n I want to get pharma grade nootrophics my spelling is bad, sorry- I’m 48 female, addicted to opioids, (subxone mainly I also take small doses of benzo’s to cope, trying to detox, went 45 days using kratom but failed cuz I did not know I had to ween off kratom.. I was taking massive doses by that time to cope with suboxone withdrawals.. have u come up with any certain cocktail to help with opiate withdrawal... if so, please share I trust your advice.. I don’t know where to start, I’m trying to avoid goin to mexico for ibogaine.. its expensive but still a possible option, appreciate it, I know ppl want free advice n bother u a lot. I don’t wana b a burden or take ur time, but figure worth asking , u have soo much knowledge. !

A:

Withstand Kratom Withdrawal with Memantine (this is a weird drug! Read my review of it first)

Selank - A BDNF-promoting neuroplasticity stimulator

And Tianeptine - this is a riskier option

Read what MisterYouAreSoDumb reported on Reddit

Plant medicine for overcoming opioid addiction

Q:

Hello Jonathan. I suffer from lack of focus and I work in a vape shop that gets at most 10 customers within an 8 hour period. I really want to get this store running efficiently so I am looking at nootropics as a focus and memory aid but I am not 100% sure what to get. I have tried phenibut, piracetam, phenylpiracetam, noopept, modafinil (modalert), and adrafinil but I haven’t taken them long enough and documented their effects before and after to really determine the pros and cons. Do you have any suggestions for stacks and what vendors to order from? Thank you. Liam

A:

Consume Nicotine responsibly

The Racetams - Follow the Piracetam Protocol

Q:

how come no company ive found uses any racetams ardafinal or theacrine in any of there preformed stacks? i want a stack that has a ton of kick to it not just passing placebo like effects also keep up the great work!

A:

Resources The Piracetam Protocol for Racetam Non-Responders

Don’t TAKE Adrafinil, use Modafinil if you must

Q:

Hey Jonathan I used to take adhd meds like concerta but I got joint pain from them. Does modafinil have the same side effects? I bought some in the black market like 10 times is original price.... Modalert 200mg. Also how can I know if my meds are original? I m afraid I’m scammed because the pills themselves don’t have anything written on their surface which is kinda odd because I never remember a drug like that. For example concerta has alza 36 written on the pill. These modafinil pills are white blankDo you develop tolerance and if so what do u suggest? Can u combine with aniracetam 750mg x2?

A:

Order Modafinil from ModafinilXL and RUPharma (EU & UK)

Q:

“Autistic” comment responding to 20 Notorious Problems of Smart Problems

A:

My articles on intelligence seem to attract long, rambling, “autistic” comments. Before leaving me one, please crystallize your thoughts somewhat into a main point. And a “compliment sandwich” (and some grammar checking) will get you a long way on the internet!

Your questions inspired this country western song about just another “Nootropics Guy”...

INVEST at least $300 in your own mind with these recommended sources and get a Biohacking consultation

Lean Life Coaching biohacking consulting

As mentioned in the podcast, this is a very lean biohacking consulting/life coaching program. Here’s how this would work...

* The Biohacking Consultation is 1 hour and 45 minutes total - which is actually two consulting calls.

* First Call 1 hour - Discovery & Strategizing call, I need to ask you some questions, we’ll discuss your history, and outline a biohacking strategy and action plan to overcome your issues.

* Second Call 45 minutes - Follow-up call in 30 or 60 days to see how you’re doing with the plan we outlined; how you’ve improved, what you’re struggling with, etc

There are a few important reasons we split the time up into two calls

* It’s a significant motivation hack for you to follow through on the biohacking habits and plan we’ll outline because you’re accountable to me in 30 or 60 days.

* I’m incentivized to come up with a really effective biohacking strategy for you because I have to talk to you after you’ve been following it for a month or two.

* It timeboxes us with a deadline of 30 or 60 days for you to make improvements and accomplish your goals.

Your skin is in the game here, that you’re paying good money for this, and you’re accountable to me on another call in 30 or 60 days. You’ll have to explain your lack of action if you fail to follow through.

Take a few minutes to answer a few questions. If your issues are far outside my areas of expertise, I’ll decline the consultation. My time is finite and very valuable, so I only want to spend it consulting the people I can really help. Thanks in advance for your understanding!

Support me on Substack? For $7/monthly?

Let’s dispense with the stereotypes first...

After the collapse of the Soviet Union, Russian businessmen had a well-deserved reputation for shady dealings. I wouldn’t blame anyone for being a little skeptical of buying Nootropics or anti-aging medicines from a Russian source. But that was 30 years ago; times have changed, and now, frankly, you should be skeptical of everyone. Government regulating agencies like the FDA are hopelessly corrupt and captured by big pharma, which is probably sponsoring your family doctor’s next luxurious vacation. The internet is a double-edged sword when it comes to your health; Amazon sells “health” supplements tainted with catastrophic amounts of toxic heavy metals, but the internet also gives you an unparalleled ability to sniff out the scams and figure out what actually works.

When choosing a Russian Nootropics source to buy from online, you want to apply a little more scrutiny than you might normally when shopping online. The reason being that you’ll probably use cryptocurrency to order from them, and unlike, for example, using PayPal, there’s no guarantee of a refund if you’re disappointed or the package gets lost en route. Virtually every eCommerce website on the internet proudly proclaims its Satisfaction or Money-Back Guaranteed! policy, but in some cases, this is internet marketing BS. Several times,s I’ve had to fill out dispute forms with PayPal or my credit card company to get refunds in cases when an e-commerce store lost my stuff and refused to honor their policies. This is not an option with cryptocurrency; once the money is transferred, there’s no way to get it back unless they decide to refund you. If you’re not satisfied with what you bought, there’s no one to go complaining to. Bank transfer or international funds transfer can be similarly difficult to get refunds for. So spend a little more time just making sure that you’re buying from a legit source. This article will help break down some criteria to judge Russian Nootropics sources.

It’s a pretty smart idea to order with cryptocurrency

Firstly, because they will often give you a small discount (who doesn’t like saving money!) Secondly, when buying drugs or exotic health supplements from abroad, you’re dabbling in what might be a legal grey area. Since founding Limitless Mindset in 201,1 I’ve talked with and heard from hundreds of biohackers around the world, and I’ve NEVER heard of a situation where a consumer got in legal trouble or was charged with a crime for ordering something. I think that almost everywhere around the world, law enforcement authorities just have better things to do than prosecute people who order things through unofficial channels. But we live in a world where online privacy and health freedom are dying. Big tech, your credit card company, and your bank have no qualms with handing your complete transaction records right over to the authorities if you ever get on the wrong side of the law. If you’re ever audited by the Internal Revenue Service, do you want them to know about the Russian Nootropics (some of which have scary-sounding names!) you’ve had shipped to you from a warehouse in Moscow or Eastern Europe? While cryptocurrency transactions are not untraceable, using cryptocurrency does much to protect your privacy and ensure that you’ll never have to explain to a law officer what Modafinil is. If you want to further insulate your privacy, you would be wise to use Monero, which is less traceable, and send the crypto from a less mainstream wallet service - Coinbase will hand over your transaction records to the government.

Before you plug your credit card or cryptocurrency into a Russian website, I urge you to first look up how long they have been in business. The internet is rife with scammy, faceless websites put up anonymously that will take your money and then disappear. For example, rusmedstore.com shut down a year after being launched in 2018. You can use Whois.net to check how long a website has been around and if its domain name is expiring soon, an indicator that it’s not a serious business. E-commerce stores that plan to be around for a while, serving customers, will usually have their domain names pre-registered for years, so check when their domain will expire.

It's crucial to do research before consuming pharmaceuticals. Pharmaceutical drugs can be abused and misused; they may have undesirable side effects. This is why buying them typically requires a doctor's prescription. The internet is rife with reports of self-administration of pharmaceuticals gone awry (like this guy, who overdosed on Memantine and had a crazy +30 hour trip!) Many will assume that if something is for sale, it must be safe and it must be regulated by some authority. In the wild, wild west of the internet, this can be a deadly assumption. Please don't be the next foolish Biohacker who kills themselves recklessly using drugs. On the other hand, we have doctors and government regulators to thank for medical catastrophes like the opioid epidemic in the United States. Often, doctors misdiagnose and overprescribe harmful drugs to their patients.

The solution is to take extreme ownership of your health and pharmaceutical decisions.

* Read studies on PubMed and health science books relevant to your questions. Learn the difference between credible double-blinded clinical trials and bad science.

* When you identify a drug or medicine that seems worthwhile, read the studies on it. Watch the videos about it and listen to podcasts discussing it. Note the dosage and usage recommendations given.

* Next, comb through the internet for anecdotal reports on it. What are people saying about using it? What side effects are mentioned? Look in forums for user reports. Search for YouTube vlogs about it. A single anecdote is not very informative; it’s an unverifiable data point, but if ten people mention the same side effect, that’s something to be considered.

* If you’re still confused, reach out to experts. Often, you can email the authors of clinical trials with questions. Crowdsource by posting questions in forums. Or contact me for a biohacking consultation.

* Once you’ve determined that a particular pharmaceutical has clinical and anecdotal evidence supporting its use for your purposes, order it from the most credible source and start with a low, conservative dosage.

It will take several hours of focused research to educate yourself, but it will be worth it, and it will likely make your decision a more informed pharmaceutical decision than your doctor makes after meeting with you for 5 minutes and jotting down a prescription.

Let’s compare some Russian vendors...

RUPharma

RUPharma is, in my view, the best option for biohackers who want to discreetly get their hands on Russian Nootropics, prescription wakefulness-vigilance agents, biopeptides, and exotic European anti-aging medicines. There are some very potent and proven nootropics, like Piracetam (NOOTROPIL®), that you can’t find on Amazon or in those aggressively marketed Nootropic stacks because they fall into a legal grey zone or are classified as not for human consumption.

What people are saying: On Trustpilot, they have an impressive 5-star average rating from nearly 200 customers. You can find a number of customer testimonials on Reddit, the vast majority of which are overwhelmingly positive. One satisfied customer reported:

I only ever contacted rupharma on 3 ocassions and each time Alexei has answered same or next day.

Pros:

* The widest choice of original Russian nootropics and generics, such as Modafinil, Armodafinil, and many others.

* While their prices are quite competitive, they offer a 10% discount for using cryptocurrency and bulk discounts of up to 30% for their most popular nootropics.

* Discounts for being a VIP customer who spends over 500 EUR or for bulk purchases.

* Regular special offers such as Buy-1-Get-1-Free on their top nootropic products.

* Reliable shipping, I’ve received about a half dozen packages from them, and a pa…

With a red and white Bulgarian bracelet on my wrist (symbolic of health, fertility, and new beginnings), I deliver this Martenitsa Edition Q&A and raise my glass to "Baba Marta" (Grandma March).

Disclaimer

What you find here is NOT medical advice. I’m not a doctor. I’m just an experienced, unlicensed self-experimenter practicing free speech by talking about my own extensive experiences and my interpretations of published science. Please see my guide on How to Biohack Smart and Safe. You should consult a doctor about any biohacking you’re doing and, ideally, also get a second opinion.

Q:

if you take [Semax] for a long period...like 4 months or maybe longer even... and then stop, will you have a lasting increased intelligence? Like, if i use it and started reading more and more and faster and faster, and increase my language aspects, use other brainparts similarly while im on it...and then after 4 months...wil there be a significant increase in intelligence, even after I quit it?

A:

Take Semax for four months

Oxiracetam - The discipline drug

Piracetam - The original smart drug

Q:

Tianeptine vs L-Tyrosine/5-HtP? Which is better i mean he said Tyro/Htp is better for motivation but also mood lifting & what about Tianeptine as a stand alone ? I need answers b/c HtP&Tyro i can try but Tianeptine i have never heard of it?

A:

Tianeptine - Not a great risk-reward trade-off

Tyrosine - A quintessential Nootropic

I have some reservations about 5-HTP

Q:

Do you think some smart dugs or a particular start drug may work well for some people, and have very little or no effect at all with others? How do you explain this? Just different genetics and brain chemistry, or maybe the quality of the product or even how its administered? Is there a good/bad way you have determined in your experience to take nootropics, or does it vary depend ending on the substance? Are there things you can do, to negative or minimise any negate effects or protect your brain chemistry and health if you’re a chronic nootropics user, or one more into taking risk and trying newer nootropics?

A:

Recommendations

The Racetams - the most potent class of smart drugs

Adaptogens - Herbs that make you antifragile (and awesome)

Modafinil - for activating "Darth Vader Mode"

Resource: My Nootropics Ingredients articles database - see the risk grades I assign

Q:

Have you ever used dna-fit, or any of these private labs that provide tests for hormone levels, biomarkers, or microbiome? They seem to suggest that having ones genetic biomarkers, hormone profile, microbiome can allow for the optimisation of ones diet, and further control of the body’s homeostasis. What are you’re thoughts?

A:

Get your personal genotyping done with Sequencing.com and your biomarkers interpreted by SelfDecode

Q:

Response to my video Qualia is Problematic - where I suggest “If you are taking them in dosages a lot lower than that, there’s no good reason to think that they will actually do you any good.”

This is false and potentially dangerous logic. Can you think of, or even imagine any nutritional that is both good for you in the tested dose, AND worse for you in lesser doses than taking none at all? Would you tell me to blow off Vitamin C completely if I could not achieve the RDA? Ridiculous! I know of no chemical that behaves as you suggest, and really, it doesn’t even make sense. Furthermore, testing of dosages rarely compares a full spectrum of dosages, rarely has long-term effects data, and rarely can give you guidance based upon the variable absorption and metabolic rate of individuals. Finally, it is a grievous error of assume that research is without bias and has been properly vetted and critiqued. Consider that all of the above concerns are especially true for nootropics (which are largely new and novel to general consumption) in particular. your advice should thus be exactly the opposite; suggesting that users of these drugs begin with a fraction of the suggested dose, and consume more only after gaging the effects.

Be more careful, my friend! You are taking on a grave responsibility when broadcasting nutritional advice. Being conservative, thorough and highly skeptical is totally appropriate.

Q:

During Tantra I feel this rush of energy & a full body sexual high & my blood pumping,etc (All this without touching my D, At All) I go to sleep on this high & next morning I feel good, refreshed, normal, what happened to my rush & semen during my sleep overnight??? No wet dreams, boxers dry, etc. Did it all reabsorb into my body? Did I do it right??

A:

Recommended reading

* The Tao of Health, Sex, and Longevity

* The Multi-Orgasmic Man

Master Mind Master Body Master Her ☯️ for a 7-part course on Tantra - become a multi-orgasmic man!

Q:

I’m curious did you get eye problem from TBI? I’m looking for treatment for possible TBI or asphyxia induced attention, depression and cognitive problem treatment. I was on tianeptine for quite a while which helped little. Now I got 1200mg piracetam prescription and starting using tomorrow.

A:

Piracetam sources - from vetted vendors

Q:

Could you make a video entirely dedicated to how to find your ideal dosage? Im a pretty big guy (6ft 5 inches, bordering 100kg) and I’ve been experimenting around with modafinil and some racetams (mainly aniracetam)to help with my ADHD but if i use the standard doses i don’t get much of a result. Id like to know how i could find my ideal dosage and cycle so that i can get the benefits of biohacking without running into a resistance curve where it becomes useless. Unrelated question: Which would you say is better, piracetam or aniracetam. Ive read around online and the general consensus is that aniracetam is better because it is faster acting and more powerful as it dissolves in lipids, not water but many people say the opposite and i wanted an expert opinion.

A:

Try pharmaceutical-grade Nicotine

Recommended reading

Head Strong by Dave Asprey

Your questions inspired this Bulgarian Horo song about a Biohacking Baba Marta...

INVEST at least $300 in your own mind with these recommended sources and get a Biohacking consultation

Lean Life Coaching biohacking consulting

As mentioned in the podcast, this is a very lean biohacking consulting/life coaching program. Here’s how this would work...

* The Biohacking Consultation is 1 hour and 45 minutes total - which is actually two consulting calls.

* First Call 1 hour - Discovery & Strategizing call, I need to ask you some questions, we’ll discuss your history, and outline a biohacking strategy and action plan to overcome your issues.

* Second Call 45 minutes - Follow-up call in 30 or 60 days to see how you’re doing with the plan we outlined; how you’ve improved, what you’re struggling with, etc

There are a few important reasons we split the time up into two calls

* It’s a significant motivation hack for you to follow through on the biohacking habits and plan we’ll outline because you’re accountable to me in 30 or 60 days.

* I’m incentivized to come up with a really effective biohacking strategy for you because I have to talk to you after you’ve been following it for a month or two.

* It timeboxes us with a deadline of 30 or 60 days for you to make improvements and accomplish your goals.

Your skin is in the game here, that you’re paying good money for this, and you’re accountable to me on another call in 30 or 60 days. You’ll have to explain your lack of action if you fail to follow through.

Take a few minutes to answer a few questions. If your issues are far outside my areas of expertise, I’ll decline the consultation. My time is finite and very valuable, so I only want to spend it consulting the people I can really help. Thanks in advance for your understanding!

Support me on Substack? For $7/monthly?

Over the past decade, I’ve followed a handful of podcasters and public thinkers whose work genuinely shaped me...

* They sharpened my thinking.

* They introduced tools I implemented.

* They accelerated my personal growth.

But something has changed. I’ll see a new episode drop. I’ll click. I’ll listen. And by the end, nothing new; just remixing, repackaging, and reiteration.

* Ideas I’ve already metabolized.

* Tactics I’ve already implemented.

* Wisdom that has already been digested.

I’m tremendously tempted to start internet drama by calling out a few of them, but I’m genuinely grateful to them, so instead I’ll try to surmise why this is happening...

Cognitive decline is real

Here’s the uncomfortable possibility: As creators push into their fifth and sixth decades, creativity and synthesis decline. The first thing cognitive aging robs us of isn’t memory. It’s novelty. It’s the ability to synthesize new frameworks. To generate fresh angles. To connect distant ideas.

And as I push into my 40s, this is something I am absolutely determined NOT to let happen to me…

What I’m doing about it

* Smart drugs - The real potent ones, like the racetams, which blunt the early edges of decline.

* Nicotine - It has some potential downsides, but for me, it’s the ultimate creativity drug.

* Memory training - The SuperMemo app is the best tool I’ve found to keep those neural bridges sturdy between disparate ideas.

* ​Dual n-back training - Is still one of the most scientifically supported ways to maintain working memory, the RAM of the mind. Working memory is upstream of synthesis. Upstream of creativity. Upstream of intellectual danger. If RAM declines, originality follows.

* Interviewing - This year, I’m devoting a lot more time to interviews than solosodes; conversations with interesting people doing innovative work in the fields of personal growth, biohacking, and anti-aging. Check out this growing playlist of Limitless podcast interviews.

But it’s not just biology...

There’s another culprit: streaming. Livestreaming creates audience capture. Superchats. Real-time feedback loops. Endless “Personal Growth 101” questions. Creators slowly drift toward talking about what their audience already understands because that’s what gets engagement. And over time? Novelty dies.

That’s one reason I don’t livestream. And don’t plan to. I’d rather deliver crafted novelty than reactive commentary.

NOT knowing when to retire

Elite athletes sometimes retire after their greatest victories. They don’t stick around long enough to become mediocre versions of themselves. Online thinkers might learn something from that. There is dignity in exiting at your peak.

What should you do when your favorite podcaster becomes unoriginal?

Unsubscribe.

Seriously.

Why cling to someone who is remixing yesterday’s ideas just because they once delivered something valuable? There are thousands of creators out there doing genuinely original work right now. The internet is not suffering from a scarcity of voices. It is suffering from an abundance of repetition.

If your old favorite suddenly produces something truly original again, trust me: you’ll hear about it. Original work makes a splash. It gets clipped, quoted, and shared. It pierces the noise.

But returning again and again to an unoriginal source simply because of history? That’s nostalgia bias. That’s sunk cost fallacy. That’s pattern addiction.

Originality is calling to you constantly online. It’s sometimes uncomfortable. It’s unfamiliar. It might be on a platform you haven’t joined because you default to using the apps pre-installed on your smartphone - like Odysee.com (some mind-blowing uncensored creativity can be found there!) It doesn’t come wrapped in the comforting voice you’ve listened to for years.

Answer the call anyway. Your mind deserves novelty. Your growth depends on it.

My commitment to you

I will continue doing my damnedest to deliver novelty. New thinking. New tools. New reporting on self-experiments. Revamping and refining my older content. New insights from the wild journey of fatherhood that I’m now 7 months into. I’ve got interviews coming that I’m genuinely excited about; conversations that break new ground.

And the most creative work I’ve done recently?

​Hourglass - +700 pages about a Biohacking cybercriminal who must master lust to save civilization from the same comet that destroyed Atlantis 12,800 years ago. That book pushed me far outside my comfort zone. That’s where novelty lives. The sequel drops on my birthday this year, May 10. If you want safe repetition, there are endless podcasts for that. If you want dangerous originality?

Stay subscribed. Read Hourglass or listen to the “Odyssey of the Mind” style audiobook (instead of yet another podcast about psychedelics or the keto diet)...

Dire in my desire to deliver novelty,

Jonathan Roseland

Support me on Substack? For $7/monthly?

After years of using Nootropics, you may get bored with consuming capsules and white powders. Switch things up with these delicious natural herbal teas...😉 Horny Goat Weed 🧠 Ginkgo Biloba 😇 Panax Ginseng 😴 Ashwaghanda 💪 Chaga Mushroom 🍵 Green Tea

For more fun vlogs about biohacking and health…

Support me on Substack? For $7/monthly?

“I knew it was killing me, but I also believed that the monster I was drowning would overtake me if I stopped. I tried various ways of controlling it, always failing eventually. My fight against drugs and alcohol was all-consuming and exhausting. In moments of exasperation, I cut my wrists and prayed for the courage to cut deep enough to let all the pain out. Luckily, I could never drive the knife that deep.”

That’s a passage I found chillingly eloquent from a chapter that Dr. Aleksandra Gajer contributed to the book Triumphs of Transformation. In it, she lays bare her struggles with vice and her long personal and professional path through traditional medicine to reclaiming agency, health, and happiness by eight foundational lifestyle pillars, which we’ll get into in this wide-ranging discussion of the science of health and the art of transformation...

Mentioned in this interview

Trauma resolution

I lost a child - Our story of recovery with EMDR/Accelerated Resolution Therapy

Methylene Blue - A fascinating and potentially world-changing effect is in helping the user overcome the fear, trauma, and PTSD of the past...

My essay: The Myth of Sex Addiction

Biohacks

Whole Genome Sequencing - If you’re an MTHFRer, don’t be so stoic about stress!

Semax and Selank - Neuroplasticity-promoting peptides

Stack these with Phenylpiracetam, then meditate to feel like "a young Jedi dabbling with the dark side of the force for the first time"

Epigenetic mindset transformation meditation - from You Are The Placebo by Dr. Joe Dispenza

Weight loss

GLP1s - Like Ozempic, Wegovy’s Semaglutide, or Manjuaro

Retatrutide - “the data is very promising!”

Books

Triumphs of Transformation: Inspiring Stories of Resilience and Life Change

Weight Lifting Is a Waste of Time by Dr. John Jaquish - instead use an X3 bar OR blood flow restriction style bands for variable resistance training

The Tapping Solution for Pain Relief

Sexaholics Anonymous White Book

The Gajer Practice

Brings “The Science of Health, The Art of Transformation” to their devotion to their patients in northern Virginia, the Washington, D.C. area, and nationwide via telemedicine.

Clearly, Dr. Gajer & Co are on the cutting edge of functional medicine and applied longevity science. So if DIYing your own Biohacking is not getting you the health transformation you need - sometimes even the best Biohacker needs a doctor - schedule a free call with them...

On social media

The Gajer Practice on Instagram, Facebook, and YouTube

Dr. Aleksandra Gajer on LinkedIN

Need a little more inspiration to break out of the pain and pattern of the past? Here’s a catchy song about trauma resolution...

Support me on Substack? For $7/monthly?

This “smart peptide” is a genetic hack for enhanced immunity, which is particularly helpful to the elderly for treating or preventing...

* Chronic and acute inflammatory diseases.

* Viral respiratory infections: pneumonia, bronchitis, sore throats, ear infections, and sinusitis.

* Autoimmune diseases.

* Cystitis, Pyelonephritis, Prostatitis, and Adnexitis.

* Systemic connective tissue disease.

* Along with recovering from chemotherapy.

Crystagen differs from other immune medicines and biohacks I’ve discussed; it’s more of a tool for restoration than prevention. It’s used to rebuild a compromised immune system.

A 2014 study out of St. Petersburg evaluated CRYSTAGEN® and explained the little-known connection between the spleen and the immune system...

The spleen plays an important role in the immune response. Its main function is the development of macrophages and different types of lymphocytes, including their proliferation and differentiation. The functional activity of the spleen reduces with aging; however, the age associated changes in its immune function are less pronounced than those of the thymus. The spleen, after the thymus, is the second most important organ of immunogenesis, which is important for both innate and adaptive immunity. Each area of the spleen provides high specificity, mediated by unique interactions between lymphoid and stromal cells. These interactions create a special microenvironment that ensures the implementation of an adequate immune response

And notes that Crystagen also activates B-cells of the immune system.

The Bioregulatory peptide mechanism is explained on Dr. Khavinson’s website here...

According to the concept of peptide bioregulation, a theory of endogenous peptide bioregulators’ involvement in the maintenance of structural and functional homeostasis of cell populations, containing and producing these factors, was formulated. These endogenous peptides became commonly known as «Cytomedins». Cytomedins control gene expression and protein synthesis, thus preventing age-related accumulation of quantitative structural and functional alterations, which are the markers of transition of a biological system from the norm to the pathology. Disordered peptide bioregulation reduces organism resistance to external and internal destabilizing factors, serving a cause of premature ageing.A long record of peptide bioregulators application in the health service has demonstrated their high effectiveness in combating various disease and pathologies, including those refractory to other medicines.

Are you perplexed by peptides?

Check out this deep-dive article and investigation of bioregulatory peptides (includes two interesting documentaries on the topic)...

Anecdotal evidence

Sofie reported, Good boost during cold/flu season!

...the Crystagen boosts my immune system for sure! I babysitting my grandchildren often and do not get sick when they are sick with cold...

FatherRomanus on Twitter combined it with other biopeptides and reported (surprisingly) a Nootropic effect in less than an hour...

the distinct effect is clarity and sharpness... Calm lucidity, like the tide rolling on your feet went up a millimeter for the natural, ten millimeters for the synthetic. We might mostly agree that it was there, like aniracetam.

I did scour Google search results for any cases of undesirable side effects reported and found none, which is a good sign!

An immune bio-prep

This package of CRYSTAGEN® is going into the “bio-prepping” corner of my immune war chest because I already have a lot of good prevention habits and biohacks: vitamins, nutrients, fasting, red light therapy, and the adaptogenic tea that I sip daily. CRYSTAGEN® I see as more of a “break in case of emergency” biohack, if myself or a loved one was facing a serious infection or autoimmune condition, I’d do a course of treatment - several capsules a day with meals for 10-30 days. It can be stored for at least five years and used when needed, so it’s a good addition to my doomsday medical prepping supplies.

For more overviews and reviews of little-known peptides and Biohacking tools…

Support me on Substack? For $7/monthly?

May your March be magnificent with these Biohacking questions answered...

Listen to it as you go about your business in the chilly streets.

Disclaimer

What you find on this website is NOT medical advice. I’m not a doctor. I’m just an experienced, unlicensed self-experimenter practicing free speech by talking about my own extensive experiences and my interpretations of published science. Please see my guide on How to Biohack Smart and Safe. You should consult a doctor about any biohacking you’re doing and, ideally, also get a second opinion.

Q&A #6 Questions

Q

I just finished watching your “Piracetam Decoded” video on YouTube and had a few questions that I was hoping you could help me with.

I have a stutter and wanted to know if, in your research, you ever came across any studies that involved Piracetam being tested on stutterers. I found a very interesting study, but it was performed on a group of stroke sufferers.

Also, in your video, you mention how Piracetam helps to improve blood flow. I tend to suffer from cold hands and feet, but not quite to the extent of having Raynaud’s Syndrome. I wanted to know if you think it would help with that as well.

A

Recommendations

For Biohacking Stuttering

Piracetam

Phenibut

Vinpocetine for vasodilation

Ginkgo Biloba

Picamilon

Beet Root Juice and Capacin

Read: The Social Anxiety Protocol for Biohacking Confidence

on Longecityhttp://www.longecity.org/forum/topic/62487-nootropic-stack-for-stuttering/http://www.longecity.org/forum/topic/13685-nootropics-for-speech-problems-stuttering-etc/http://www.longecity.org/forum/topic/61978-stuttering-and-neurofeedback/

Q

what Nootropics can you use safely if you elevated blood pressure?

A

RecommendationsOxiracetam

Aniracetam

Piracetam

Q

Hello. What do you think about stacking vinpocetine with supplements that increase dopamine and serotonin levels? L-tyrosine is the building block of dopamine. Mucuna contains l-dopa, the precursor to dopamine. 5-htp creates serotonin. I think l-theanine does too. They might help, but I would like an educated opinion before I try. I feel like I might be one of the people who gets depressed from vinpocetine, but I am intrigued by its potential benefits. P.S. Could you make a video about which nootropic you would take if you could only take one?

A

Recommendations

L-Phenylalanine

Tyrosine

Caballo - If I could take just one Smart Drug, it would be the racetam-rich stack I created

Q

hey do you know anything that helps you get into a calm state except for meditation, L theanine, and kratom high-dose?

A

RecommendationsDual N-Back

Kava

Phenibut

Yoga and breathwork

Q

Why is Rhodiola Rosea so Popular in Smart Drug Stacks? Thoughts?

A

Recommendation

Organic Rhodiola Rosea Extract

Your questions inspired this old school hip hop song about Biohacking...

To get your yearning biohacking questions answered, first…

Support me on Substack? For $7/monthly?

Is beauty vain, or is beauty, instead, a philosophical treasure that refracts the potency of our inner life force?

Is physical beauty something we’ve programmed to respond to by the 5000 ads a day? Is the obsession with one’s own physical beauty a sign of a deeply corrupt soul? If all you have to offer is that which you did not earn, you’ll be terrified to lose it. Is the lustful obsession with physical beauty the way of what appears to be a man, but is really an animal?OR is physical beauty a gift from the divine (or evolution if you prefer)? A reward for when we draw nearer to the most metaphorically divine act, that of creating new life in our own image.

It’s all too easy to call the woman vain who spends hours before the mirror fixing her make-up. Mainstream self-help pop culture would call her insecure for the way she frets over how her attire falls on her form. Surely, she must be compensating for her intellectual shallowness or bad childhood when she rouges her lips. But what about the health-conscious Biohacker - who spends hundreds of hours a year in the gym shaping their physique? Who never misses a day without their collagen supplements? Who shines beautifying wavelengths of red light on their skin every day? The Biohacker who dares to defy human condition: grow old, grow ugly, and die - long thought of as nonnegotiable. The Biohacker who spends a small fortune on sophisticated anti-aging supplements and tools for the fight to become a beautiful immortal, have they merely multiplied vanity by delusion?

These are the most pragmatic of philosophical questions. I discuss them with François Vix, who has dedicated the past two decades to advancing health through scientific breakthroughs in the beauty and wellness space. Most notably, he pioneered the use of a stable, bioactive form of SuperOxide Dismutase (SOD), bringing GliSODin to more than 50 countries. I’ve trialed their two products: GliSODin Anti-Aging and VSOD. These are more than just beauty products, with over 20 clinical trials backing SOD’s effect on health and longevity, it may be one of the keys for aspirational beautiful immortals.

Mentioned in this interview

SuperOxide Dismutase (SOD) on PubMed

Derived from organic Melons farmed in Provence, France

GliSODin multiplies the effect of more mainstream “beauty supplements”: Collagen, Hyaluronic Acid, Vitamin C, etc

GliSODin.org - research portal with +20 studies

The hacks

Lifestyle longevity hack for SOD: take the advice of the Taoist masters and train take fewer breaths

Minimalist hack for productivity: Name just one goal a day during a morning breathwork session. I do this listening to Othership’s Morning Intentention track

A snapshot of one of the most beautiful places I ever visited - Valencia, Spain

My book about how to seduce the enduring affections of a virtuous and beautiful woman: Don’t Stick Your Dick in a Blender

Biohacker review: The vitality (and great hair) that new-ish parents need!

My wife and I took both GliSODin Anti-Aging and VSOD for about two months. I wouldn’t categorize them as classic Nootropics, but I think they are something that helped with the energy we need as new parents - I’m proud of how well we’ve managed the avalanche of new responsibilities (elevated SOD probably has something to do with that)! Additionally, I noted that my wife’s hair was looking particularly vibrant while we were making love on Valentine’s Day.

As you can tell, I really like what GliSODin is about, so I’ve included them in the illustrious ranks of Limitless Mindset Secret Society partners. Pick up over $300 worth of their products, and you’ll be eligible to join our Biohacker secret society and get a free consultation session with me.

Check out GliSODin on Instagram or YouTube

Take-away question: Beauty is a silver lining to life that makes hardships endurable, so how can you earn more beauty in your life in 2026?

My discussion with François inspired this epic song about the philosophy of beauty...

Support me on Substack? For $7/monthly?

Q

Responding to: Prepping for an Uncertain Future with Nootropics

i don’t think they ever put a man on the moon... but i’ll never believe there’s nuthin’ up their sleeve!I don’t buy into cold war propaganda either. But I also know that flat Earth is a psyop to distract, discredit, and draw out thought criminals. Pretty effective psyop.

A

My connection the moon landings...

The moon conspiracies go deeper...

* Richard Hoagland’s theory and debates on the moon landings

* JF Debunks the Moon Landing Conspiracy (in 3 hours!)

This question inspired this (AI) art...

Q

what do you think of maca for sport ? what would you recommand for intense swimming ? no dopamine inductor, I don’t use coffee neither for instance. I believe everything that use dopamine receptor has a cost in the end, not worth it to my view. ( any thought on this, cause coffee fuck the hell up of me in the end of day, maybe I m really sensitive to this ).

A

More about Maca: PubMed articles on endurance effect: A pilot investigation into the effect of maca supplementation on physical activity and sexual desire in sportsmen.

14 days ME supplementation improved 40 km cycling time trial performance and sexual desire in trained male cyclists.

Retracted article: The Research on the Impact of Maca Polypeptide on Sport Fatigue.

Nootropics for intense swimming...

Gotu Kola from an Indian review

The antidepressant effects of total triterpenes from [Gotu Kola] on the immobility time in forced swimming mice...

L-Tyrosine for acute stress

Rhodiola from a Belgian study of young athletes:

Acute Rhodiola rosea intake can improve endurance exercise capacity in young healthy volunteers.

Yohimbine - an athletic performance enhancer

Q

Hello Jonathan. Please tell me what do you think about Flmodafinil. I’ts safe? Dont give me SJS? Or allergy and skin interaction like adrafinil? Thanks for your answer :)

A

More about FlmodafinilCortex Labs ReviewNo clinical studies on Flmodafinil on PubMed

Q

John have you ever heard or tryed Omega-3 from red krill and not wild caught salmon or from sardine ect.. The absorption of this omega 3 krill oil is something amazing you can really feel it. The scientific logic behind this is that the loads of golden omega 3 pills we see with huge amounts of DHA and EPA are not fully getting absorbed .The red you see is a powerfull anti oxidant Astaxanthin which is naturally found in krill and helps preserve the omega 3 so no smelly fishy smell

A

Listen: Ben Greenfield’s podcast with Twinlabs CEO

Order: Red Krill Omega-3 Oil

Q

Responding to: Post-Piracetam Intelligence Deficit

Thanks for sharing. I’ve read many reddit posts myself and many of the things that I have read are absurd. One, in particular, was a guy complaining about various negative side effects that came with his noopept consumption, although he then states that he was using modafinil along with it, but he was sure that it was the noopept which was causing him to crash and have extremely low energy upon it wearing off, absolutely comical! Others have stated that noopept has ruined their brain despite the fact that they had abused substances such as benzodiazepines shortly prior to trying noopept. It seems that many individuals are trying to fix an underlying problem with certain nootropics and then if they have some sort of negative result after their use they are certain to pin the problem on the nootropic. In my experience, noopept is very subtle and it has had a positive impact on my brain therefore I cannot fathom how some can claim that this substance has had any significant negative impact on their brain. Also, isn’t noopept most effective for those with neurodegenerative diseases such as Alzheimers?

A

Read: Noopept stimulates the expression of NGF and BDNF in rat hippocampus.

Hello Jonathan. Please tell me what do you think about Flmodafinil. I’ts safe? Dont give me SJS? Or allergy and skin interaction like adrafinil? Thanks for your answer :)

Q

Responding to: Kratom 🌿 An opioid-based non-nootropic performance enhancer with a dark side

[Kratom is an] opioid agonist buddy not a legit opioid for real

A

78 papers on PubMed identify Kratom as an opioid or as having opioid properties

Q

How do racetams effect Bipolar Disorder especially mania?

A

Read: The cause of Piracetam Mania and Nootropics for bipolar people - Racetams induce hypomania?

Better Nootropic options...

Vitamin B12

ALCAR - A 2013 paper stated about a stack of ALCAR and CoQ10:

[mitochondrial modulators] treatment targets mitochondrial dysfunction, oxidative stress, altered brain energy metabolism and the dysregulation of multiple mitochondrial genes in patients with bipolar disorder... Convergent data implicate mitochondrial dysfunction as an important component of the pathophysiology of bipolar disorder.

Uridine

Memantine - I’ve grown more bearish on this drug

Q

Responding to: How to Be Cross Eyed audio chapters

Great series. May I ask how you came to be able to write and publish a book? Is there a streamlined way to do this these days?

A

My books: How to Be Cross Eyed, Hourglass, and Don’t Stick Your Dick in a Blender

Kindle Book Formatting Tool: Reedsy

Your questions inspired this song: “Question the conspiracy theorist cred” 🎵 Disco for your doubt

INVEST at least $300 in your own mind with these recommended sources and get a Biohacking consultation

Lean Life Coaching biohacking consulting

As mentioned in the podcast, this is a very lean biohacking consulting/life coaching program. Here’s how this would work...

* The Biohacking Consultation is 1 hour and 45 minutes total - which is actually two consulting calls.

* First Call 1 hour - Discovery & Strategizing call, I need to ask you some questions, we’ll discuss your history, and outline a biohacking strategy and action plan to overcome your issues.

* Second Call 45 minutes - Follow-up call in 30 or 60 days to see how you’re doing with the plan we outlined; how you’ve improved, what you’re struggling with, etc

There are a few important reasons we split the time up into two calls

* It’s a significant motivation hack for you to follow through on the biohacking habits and plan we’ll outline because you’re accountable to me in 30 or 60 days.

* I’m incentivized to come up with a really effective biohacking strategy for you because I have to talk to you after you’ve been following it for a month or two.

* It timeboxes us with a deadline of 30 or 60 days for you to make improvements and accomplish your goals.

Your skin is in the game here, that you’re paying good money for this, and you’re accountable to me on another call in 30 or 60 days. You’ll have to explain your lack of action if you fail to follow through.

Take a few minutes to answer a few questions, if your issues are far outside my areas of expertise I’ll decline the consultation. My time is finite and very valuable, so I only want to spend it consulting the people I can really help. Thanks in advance for your understanding!

Support me on Substack? For $7/monthly?