This episode dissects a randomized controlled trial that investigates whether inhaled isopropyl alcohol is more effective than oral ondansetron for treating nausea in emergency department patients.

April MD, Oliver JJ, Davis WT, et al. Aromatherapy Versus Oral Ondansetron for Antiemetic Therapy Among Adult Emergency Department Patients: A Randomized Controlled Trial. Ann Emerg Med. 2018:1-10. doi:10.1016/j.annemergmed.2018.01.016

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This episode does a deep dive into a 2026 systematic review and meta-analysis that examines how brief standing or physical activity breaks affect acute cognitive performance compared to uninterrupted sitting.

Zhuang M, Yin M, Liu Z, et al. Acute cognitive effects of interruptions to prolonged sitting with brief standing or physical activity breaks: a systematic review and three-level meta-analysis. Int J Behav Nutr Phys Act. Published online July 13, 2026. doi:10.1186/s12966-026-01953-6

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@anthonynovello.dpt

This episode dissects a study that analyzes data from over 147,000 participants across three decades to determine how long-term resistance training influences life expectancy.

Zhang Y, Lee DH, Rezende LFM, Ma Y, Giovannucci E. Long-term resistance training with all-cause and cause-specific mortality: assessing dose- response and joint associations with aerobic physical activity. Br J Sports Med. 2026;60:874-883. doi:10.1136/bjsports-2025-110503

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This episode dissects a systematic review and meta-analysis that evaluates the efficacy of six specific exercise therapies—core stability, Tai Ji, aquatic therapy, yoga, sling exercise, and combined training—for treating low back pain.

Cheng M, Tian Y, Ye Q, Li J, Xie L, Ding F. Evaluating the effectiveness of six exercise interventions for low back pain: a systematic review and meta-analysis. BMC Musculoskelet Disord. 2025;26:433. doi:10.1186/s12891-025-08658-0

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This episode does a deep dive into a systematic review that evaluates whether chiropractic spinal manipulation effectively treats various headache types, including migraines, tension-type, and cervicogenic headaches.

Ceballos-Laita L, Ernst E, Carrasco-Uribarren A, García-García D, Jiménez-del-Barrio S. Is chiropractic spinal manipulation effective for the treatment of cervicogenic, tension-type, or migraine headaches? A systematic review. Eur J Integr Med. 2025;76:102462. doi:10.1016/j.eujim.2025.102462

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This episode dissects a scoping review that investigates therapeutic interventions designed to prevent upper limb repetitive strain injuries (RSIs) among workers using computers in the 21st century.

de Waal A, Killian A, Gagela A, Baartzes J, de Klerk S. Therapeutic approaches for the prevention of upper limb repetitive strain injuries in work-related computer use: a scoping review. J Occup Rehabil. 2025;35:234-267. doi:10.1007/s10926-024-10204-z

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This episode dissects an article that analyzes data from over 135,000 patients to determine the long-term probability of requiring a knee replacement following ACL reconstruction.

Hennessy C, Murray J, Price AJ, Abram SGF. Long-term risk of knee replacement after ACL reconstruction using the contralateral knee as an internal control: a National Hospital Episode Statistics database study of 135 881 patients. Br J Sports Med. 2026;60:865–873. doi:10.1136/bjsports-2025-111503

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This episode dissects a systematic review that evaluates the effectiveness of various medical and behavioral strategies used to prevent knee osteoarthritis. By analyzing data from multiple randomized controlled trials, the researchers assessed interventions such as weight management, physical exercise, nutritional supplements, and drug injections.

Almeida Silva HJ, Perea J, Dantas G, et al. Intervention strategies for preventing knee osteoarthritis: a systematic review. JOSPT Open. 2026;4(3):264-275. doi:10.2519/josptopen.2026.0155

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This episode does a deep dive into an article that addresses the critical need for a standardized approach to early-stage symptomatic hip osteoarthritis, a phase where pain and functional decline occur before major damage appears on traditional X-rays.

Heerey J, van Klij P, Diamond LE, Mascarenhas V, Whittaker JL, Agricola R, et al. Early-stage symptomatic hip osteoarthritis: a window of opportunity. J Orthop Sports Phys Ther. 2026;56(7):399-412. doi:10.2519/jospt.2026.14223

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This episode does a deep dive into a research paper that investigates whether following standard dietary guidelines provides enough flavanols to achieve the cardiovascular benefits observed in the COSMOS clinical trial.

Ottaviani JI, Erdman JW Jr, Steinberg FM, et al. Adhering to dietary guidelines does not yield flavanol intake levels associated with beneficial cardiovascular effects. Food Funct. 2026;17:5715. doi:10.1039/d6fo00867d

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