Editor Helen Frankish discusses highlights from the December issue: original research investigating the efficacy of minocycline for the treatment of amyotrophic lateral sclerosis (ALS); a randomised trial assessing the effect and treatment duration of topiramate for the prevention of migraine; and a brief discussion of a review about medulloblastoma in children.

Editor Helen Frankish discusses highlights from the November issue: two Articles looking at the early treatment of minor strokes or transient ischaemic attacks and the risk of stroke, an Editorial calling for more funding for headache research, and a large multinational study identifying genetic variants that influence the development of epilepsy.

Editor Helen Frankish discusses this month's leading edge editorial: the unsuccessful appeal against the UK National Institute for Health and Clinical Excellence (NICE) after its recent decision to not make dementia therapies widely available in the UK on grounds of cost-effectiveness

Editor Helen Frankish discusses highlights from the September issue: an association between Epstein-Barr virus and acquisition of multiple sclerosis in children; and current opportunities for the development of anti-epileptic drugs. Epilepsy and HIV are also discussed in this month's leading edge editorial.

Editor Helen Frankish discusses two topics from the August issue: a research article suggesting people with epilepsy are three times more likely than the general population to commit suicide; and she interviews the author of a position paper about a new research framework for the diagnosis of Alzheimer's disease.

In this month's Lancet Neurology podcast Helen Frankish discusses a research article concerning numerous factors which determine the risk of recurrent venous thromboembolism after cerebral venous thromboembolism in children. Also discussed is the Leading Edge editorial calling for a more modern approach to stroke services in the UK, and the review about silent infarcts, which could be a useful way of detecting neurological disease before symptoms develop.

Editor Helen Frankish discusses highlights from the June issue: research from the University of Oxford about the incidence of haemorragic stroke; while incidence has decreased in younger age groups over the past two decades, inclusion of data from people aged over 75 years shows how overall incidence has remained the same, underlining the need for the inclusion of older people in stroke research. Also discussed is the comprehensive review on migraine and this month's editorial about stem-cell research in the USA.

Editor Helen Frankish discusses highlights from the May issue. The GIST trial concerning blood glucose levels after stroke, despite being stopped early, has implications for future research in this area.

Editor Helen Frankish discusses the April issue, including promising research on occipital-nerve stimulation for cluster headache, and a new method to aid the diagnosis of Lewy body dementia.

Editor Helen Frankish discusses highlights from the March issue: a pooled analysis of three randomised trials which shows how decompression surgery soon after stroke onset can reduce mortality.