Paul Kluetz from the US FDA discusses the issues surrounding the use of patient-reported outcomes in regulatory decision making.

Michael Hoeckel joins The Lancet Oncology to discuss his latest trial on the surgical treatment of vulvar carcinoma based on the theory of ontogenetic cancer fields.

Håvard Emil Danielsen joins The Lancet Oncology to discuss his latest paper on machine learning algorithms to analyse chromatin organisation as a prognostic marker for cancer.

Ross Camidge discusses RANO's papers on clinical trial design for patients with brain metastases.

John Field discusses a European position statement on lung cancer screening using low-dose CT.

Commission co-chairs Chi Van Dang and Elizabeth M. Jaffee discuss a new Lancet Oncology Commission on cancer treatment and care in the USA.

Ben Anderson talks about cancer care and cancer trends in Peru.

Ricky Sharma discusses results from three prospective trials on the use of selective internal radiotherapy for liver metastases from colorectal cancer.

Samra Turajlic discusses the contribution of small insertions and deletions to tumour-specific antigen analyses.

Percy Lee discusses the impact of prior radiotherapy on the efficacy of pembrolizumab when used to treat non-small cell lung cancer.