Elysia Alvarez (UC Davis Comprehensive Cancer Center, Sacramento, USA) discusses her Article on the analysis of the global burden of adolescent and young adult cancer in 2019.

Aju Mathew (Malankara Orthodox Syrian Church Medical College and Hospital, Kerala, India) discusses his Review on financial toxicity in cancer care in India.

David Pinato (Imperial College London, Hammersmith Hospital, London, UK) discusses his Article on prevalence and impact of COVID-19 sequelae on treatment and survival of patients with cancer who recovered from SARS-CoV-2 infection.

James Glasbey (UK NIHR Global Health Research Unit on Global Surgery, University of Birmingham, Birmingham, UK) discusses his Article on the effect of COVID-19 pandemic lockdowns on planned cancer surgery.

Manju Sengar (Tata Memorial Centre, India) and Christopher Booth (Queen’s University Cancer Research Institute, Canada) discuss their Article on the comparison between cancer drugs deemed essential by oncologists and those included in the WHO Essential Medicines List.

Series authors discuss the Global Cancer Control Networks Series on how high-income countries, particularly the UK and Canada, can help with cancer control in low-income and middle-income countries.

Rafael Cardoso and Hermann Brenner (German Cancer Research Center, Heidelberg, Germany) discuss their recent paper on colorectal cancer incidence, mortality, and stage distribution in Europe.

Takayuki Yoshino (National Cancer Center Hospital East, Kashiwa, Japan) discusses the DESTINY-CRC01 trial on trastuzumab deruxtecan in patients with HER2-expressing metastatic colorectal cancer.

Roberto Orecchia (European Institute of Oncology IRCCS) discusses the ELIOT trial on intraoperative irradiation for early breast cancer.

Hedvig Hricak (Memorial Sloan Kettering Cancer Center), Andrew Scott (Olivia Newton-John Cancer Research Institute), Rifat Atun (Harvard TH Chan School of Public Health), and May Abdel-Wahab (International Atomic Energy Agency) discuss The Lancet Oncology’s Commission on Medical Imaging and Nuclear Medicine.