Inappropriate use of opioids after surgery has contributed substantially to the global opioid epidemic. Lead author Paul Myles (Alfred Hospital and Monash University, Melbourne, Australia) discusses a new Lancet Series that proposes alternative approaches for pain management after surgery.

TH Lam (University of Hong Kong) discusses a proposal for an international framework convention for alcohol control, given the totality of recent evidence that there is no safe limit for alcohol consumption.

Shakila Thangaratinam (Queen Mary University of London, UK) discusses a systematic review and meta-analysis which highlights the increased risk of perinatal trauma and mortality associated with C-section use in low income and middle income countries.

A new Lancet Commission maps out priorities in diagnosis, treatment, prevention, and advocacy efforts to end tuberculosis by 2030. Detailed discussion with two of the commissioners: UN Tuberculosis Special Envoy Eric Goosby, and Paula Fujiwara from the International Union against tuberculosis and lung disease. The podcast is introduced by Liz Zuccala from The Lancet.

Alan Stein, Brenda Kelly (University of Oxford, UK), and Ruth Bland (Royal Hospital for Children, Glasgow, UK) discuss a two-part Series that is helping to develop guidelines for health-care professionals and families concerning life-threatening conditions in children or their parents.

Patrick Rossignol (University of Lorraine, Nancy University Hospital/INSERM, France) discusses recent progress and future challenges concerning heart failure, notably a widespread lack of implementation of established clinical guidelines.

Annette Regan (A&M University, Houston, USA) discusses an observational study which assesses an appropriate time interval for conception after stillbirth.

Mark Greenwald discusses buprenorphine extended release—a once-monthly injected formulation for the treatment of opioid use disorder recently approved by the US FDA.

Discussion of a special themed issue introduced by Lancet Editors Jocalyn Clark and Liz Zuccala, with contributions from #LancetWomen advisory group members Ravi Verma (International Center for Research on Women, New Delhi, India), and Imogen Coe (Ryerson University, Toronto, Canada).

Discussion with Obesity commission co-authors Bill Dietz (George Washington University, USA) and Boyd Swinburn (University of Auckland, New Zealand), plus three personal testimonies about the impact of obesity relating to stigma, indigenous culture, and health.