In 2018, a $25,000 grant was awarded to Dr. Kerry Delaney to study neural connectivity in mosaic brain tissues using newer optogenetic techniques, hoping to shed further light on the clinical implications of the real-world heterozygosity in female Rett syndrome brains.

In 2021, ORSA awarded $25,000 to Dr. Alexander Weber's study is entitled Functional, Metabolic, and Structural MRI Findings in Rett Syndrome.

In 2018, a $25,000 grant was awarded to Dr. Mojgan Rastegar to study the role of metformin (a current and commonly available drug, used most frequently in the treatment in diabetes) as a potential therapeutic agent in the treatment of Rett Syndrome.

In 2015, Dr. Juan Ausio was awarded $50,000 in partnership with Dr. John Vincent for their project entitled Translational correlation of MeCP2 chromatin alterations in male and female missense mutations.

In 2019, the pair was awarded a further $100,000 for Therapeutic small molecules and peptides targeting missense mutations in Rett Syndrome.

In 2015, Dr. John Vincent was awarded $50,000 in partnership with Dr. Juan Ausio for their project entitled Translational correlation of MeCP2 chromatin alterations in male and female missense mutations.

In 2019, the pair was awarded a further $100,000 for Therapeutic small molecules and peptides targeting missense mutations in Rett Syndrome.

Dr. James Eubanks was awarded $25,000 in 2016 for his study: Testing new read-through drugs for prospective treatment of Rett Syndrome.

In 2019, Dr. Eubanks was awarded a second grant of $50,000 for his project entitled A Preclinical Trial In MeCP2-Deficient Mice To Test The Repurposing Potential Of An FDA-Approved Drug For Use In Rett Syndrome.