"Littoral Science: A Manifesto for the Next Scientific Revolution," argues that science is on the verge of a paradigm shift, marked by the integration of AI and human collaboration. It proposes a new scientific framework, dubbed "Littoral Science," where real-world experiments and computational models co-evolve, enhancing discovery through a feedback loop. This approach emphasizes the importance of human judgment and creativity while harnessing the power of AI for data analysis, hypothesis generation, and modeling complex systems. The author highlights the ethical and epistemological challenges that arise with the increased reliance on AI, emphasizing the need for ethical inquiry alongside scientific advancement.