Dr. Amit Sharma was awarded a Master’s degree in Biomedical Sciences from Delhi University, India. He received his PhD in 2009 in Biotechnology from University of Pune for his work demonstrating microRNA regulation of cytokines invovled in allergic inflammation in mice models. Dr. Sharma’s postdoctoral research at the Buck Institute, Novato, California involved investigating novel molecular regulatory pathways in regards to genotoxic stress and cellular senescence in invertebrate and mammalian models.

Dr. Sharma has recently joined SENS Research Foundation as Group Lead in the Senescence Immunology Research Group. His research focus involves studying how aging and senescence affects the immune system and his research group will also investigate strategies to harness the immune system in mitigating deleterious effects of senescent cells with translational focus.

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Amit Sharma Linkshttps://www.sens.org/about-us/team/https://youtu.be/AoRb1Z0XanMhttps://www.sens.org/our-research/https://www.linkedin.com/in/amit-sharma-1613b189/

Timestamps00:00 Dr. Amit Sharma00:45 Which path to achieve longevity/ healthspan02:40 integrated approach03:50 Typical week working on longevity07:20 Black swan events / SENS foundation08:30 Too high risk ideas09:09 Innovation brain / Elon Musk10:50 Dyslexia thinking in 3d and how Amit thinks12:40 Seeing opportunities14:20 Amit Sharma Leadership style16:00 Spinning off companies vs staying in pure research18:30 Mentorship, life events, inspiration and seeing longevity as the path for her21:00 Skills to be successful in longevity24:55 Project / moments at SENS that is awesome27:15 Longevity and Iron30:17 Visualizing senescence apoptosis32:30 Other uses / Cancer applications / USF34:40 Immune system not aware of eyes35:52 Blood brain barrier degradation with ate, NK cells, t cells36:47 T -cells, inflammation, and alzheimer's38:44 Crazy ideas for treating alzheimer’s disease40:40 Cost to build an Amit Sharma center of research within SENS / Idea for Lisa43:00 Donating money to SENS / mito mouse45:00 Ancient infections hiding in genome47:35 Gut microbiome longevity Drosophila52:25 Mice / research / history of work56:30 Cell culture, senescence, mouse models creating new perspectives57:40 FanQ How do you know that the allogeneic CAR-NK cells won't cause Graft vs Host disease?1:00:01 FANQ How many possible senescent cell markers do you think there may be in senescent cells? Do you see being able to target say 70% of Senescent cells with just say 10 markers?1:03:50 FANQ How far do you think you are from an IND application?1:05:55 FANQ Do you have an orphan indication you might want to target first?1:06:50 Book recommendations1:10:00 Amit on never retiring1:10:30 What he needs help with