In this episode, we unpack the critical nursing skill of titrating intravenous medications, focusing on how to safely adjust dosages based on patient-specific parameters such as aPTT results and physical assessments. We’ll explore what makes a valid provider prescription and the essential elements of a titration protocol, including starting doses, frequency of adjustments, and clinical limits. Special attention is given to Heparin, a high-alert anticoagulant, reviewing its mechanism of action, weight-based infusion calculations, and bolus dosing strategies. Through practical examples, we’ll walk step-by-step through low-dose and high-dose Heparin titration protocols, emphasizing accurate dosage adjustment, patient monitoring, and safety practices to prevent bleeding complications and ensure therapeutic effectiveness.