Matter of Fact: A play on "matter" (physics) and "facts" (news).

In September 2021, a Wisconsin farmer discovered a Mercedes SUV abandoned in a cornfield containing the bodies of four victims who had been fatally shot at close range. Investigators used surveillance footage and cell phone signals to track the movements of the primary suspect, Antoine Suggs, and his father, Darren Suggs, who assisted in transporting the bodies and disposing of evidence across state lines. Despite Antoine's claims of self-defense during a drug-related robbery, forensic evidence and his composed behavior after the shootings led to his conviction and a 102-year prison sentence, while his father was sentenced to five years for his involvement.

In November 2018, 18-year-old Samantha Guthrie was reported missing by her father, a gang member, triggering an investigation that revealed she was shot by career criminal Danny Hamby at a drug house in Akron, Ohio. Witness testimonies detailed how Hamby and his girlfriend Tony placed the still-breathing Samantha into a car trunk and fatally stabbed her after she began to scream, eventually dumping her body in a remote wooded location. Danny Hamby was subsequently sentenced to life in prison with the possibility of parole after 24 years, while Tony and several accomplices also received prison sentences for their involvement in the murder and the disposal of evidence

On March 19, 2024, 14-year-old Carly Gregg shot and killed her mother, Ashley Smiley, in their Mississippi home after her mother discovered Carly’s drug use and a secret phone. Following the murder, Carly used her mother's phone to lure her stepfather home and shot him (he survived), and she also invited a school friend over to view her mother's body while showing no apparent remorse. Although the defense argued she was suffering from a mental breakdown and legal insanity, a jury found her guilty of first-degree murder and sentenced her to life in prison without the possibility of parole.

True Crime Story updates on several high-profile cases, including the Idaho University murders where Bryan Kohberger’s defense claims a night-driving alibi and the Angela Chao drowning, which was officially ruled an accident caused by intoxication. Recent legal resolutions include a 35-year prison sentence for Qinxuan Pan for the murder of Yale student Kevin Jiang and a permanent life sentence for Erica in the 2012 pizza delivery murder following an unsuccessful appeal. Additionally, the video discusses the not guilty by reason of insanity verdict for Austin Harrouff in a 2016 assault and the dismissal of charges against Michael Turney in the 23-year disappearance of his stepdaughter Alissa.

On September 6, 2018, Dallas police officer Amber Guyger shot and killed 26-year-old accountant Botham Jean after mistakenly entering his apartment, which she claimed she believed was her own,. During the trial, evidence revealed that Guyger was distracted by a lengthy phone call with her colleague and lover, leading her to miss multiple physical cues—including a distinctive red floor mat and different room numbers—that indicated she was on the wrong floor,,. Ultimately, a jury rejected her claims of self-defense, convicting her of murder and sentencing her to 10 years in prison, a proceeding marked by Jean's brother offering Guyger a public gesture of forgiveness.

In February 2007, a horrific mass murder occurred at the "Nian Yu Jiu Lou" Chinese restaurant in Sittensen, Germany, resulting in the deaths of the owners and five employees who were bound and shot during a robbery. The perpetrators, a group of five Vietnamese men including a former employee, targeted the restaurant to steal money to cover gambling and drug debts, though they spared the owners' two-year-old daughter who was found unharmed at the scene. Following a breakthrough during a routine traffic stop, the suspects were arrested and convicted, with the primary shooters receiving life sentences for their roles in the massacre.

In January 2019, Danielle Redlick called 911 to report the death of her husband, Michael Redlick, initially claiming he suffered a heart attack before admitting they had a violent altercation involving a knife. Investigators found a cleaned crime scene smelling of bleach and discovered that Danielle had waited eleven hours to report the death, during which time she searched for suicide methods and browsed a dating website. Although the prosecution argued she was a cold-blooded killer, the jury acquitted her of second-degree murder based on claims of self-defense against domestic abuse, convicting her only of tampering with evidence.

In April 2011, the bodies of Agnès Dupont de Ligonnès and her four children were discovered buried under their garden terrace in Nantes, France, having been drugged and executed while the primary suspect, the father Xavier, vanished. Investigations into the family's private life revealed that Xavier was a man of aristocratic descent struggling with extreme financial debt and a double life, possibly influenced by his mother's cult-like religious views to "save" his family through death,. Despite being the target of an international manhunt and numerous reported sightings across the globe, Xavier remains at large, with his ultimate fate—whether he died by suicide or successfully escaped abroad—remaining one of France's greatest mysteries.

On June 12, 1977, three young girls—Lori Farmer, Michele Guse, and Denise Milner—were sexually assaulted and brutally murdered at Camp Scott in Oklahoma during their first night of summer camp. Investigators soon focused on Gene Leroy Hart, a local fugitive and convicted rapist, after discovering a nearby cave containing stolen items from the camp and newspaper scraps that matched evidence found at the crime scene. While Hart was acquitted in 1979 due to insufficient physical evidence at the time, modern DNA testing and a comprehensive re-examination by experts in recent years have concluded that he was the person responsible for the crimes.

Brian Steven Smith, a South African immigrant living in Alaska, was sentenced to 226 years in prison for the murders of Kathleen Henry and Veronica Abouchuk. The case was cracked after a woman discovered an SD card containing graphic videos of Smith torturing a victim, which led to a search of his home where police found dozens of storage devices and eventually secured his confession. Investigators believe Smith may be a serial killer with additional victims, citing unidentified DNA found in his truck and reports of him boasting about multiple murders committed while living in South Africa.