The Centers for Medicare and Medicaid Services (CMS) will soon release the 2022 Medicare Physician Fee Schedule (PFS) and the Hospital Outpatient Prospective Payment System and Ambulatory Surgical Center (OPPS/ASC) Proposed Rules. Sheila Madhani, Deborah Godes, and Devin Stone share the significant impact these rules will have on Medicare fee-for-service spending on physician and hospital outpatient services, and on quality reporting in the upcoming calendar year.