MDedge Cardiocast

Strong showing for TAVR after 5 years in PARTNER 2ATranscatheter and surgical aortic valve replacement had similar rates of death or disabling stroke.

* * *

Help us make this podcast better! Please take our short listener survey: https://www.surveymonkey.com/r/podcastsurveyOct2019

* * *

Patiromer allows more CKD patients to continue on spironolactone After 12 weeks, 86% of the patiromer patients remained on spironolactone, vs. 66% of the placebo patients.

Native Americans appear to be at increased risk for AFib Atrial fibrillation was significantly more common among Native Americans than in other racial and ethnic groups.

Certain diabetes drugs may thwart dementia Intriguing findings from a Danish national registry study

For more MDedge Podcasts, go to mdedge.com/podcasts

Email the show: [email protected]

Interact with us on Twitter: @MDedgeTweets

MDedge reporters discuss the latest in practice-changing data from the 2019 annual congress of the European Society of Cardiology in Paris.

Join Mitchel L. Zoler, Bruce Jancin, Kari Oakes, and MDedge Cardiology editor Catherine Hackett as they discuss what they reported from the annual meeting.

Statin use linked to risk of skin and soft tissue infections

Use of statins was associated with increased risk of SSTIs at an average of 91, 182, and 365 days.

Rivaroxaban trends toward higher thrombotic risk than vitamin K antagonists in APS

Patients who took rivaroxaban experienced almost two times as many thrombotic events as patients who took dose-adjusted vitamin K antagonists.

HHS floats Stark/anti-kickback revisions to support value-based care

Health law attorneys say reforms should remove some of the risk in value-based care arrangements that exist under current law.

* * *

Card Talk:

Cardiologist brothers Jim and Jerry Dwyer welcome Jennifer N. Avari Silva, MD, and Berk Tas, to talk about an investigational system for electrophysiology procedures that displays holograms of patients' anatomies in real time. The SentiAR system uses an augmented-reality head-mounted display that allows physicians to manipulate the data and enhance their understanding of the case.

Dr. Avari Silva, MD, is assistant professor of pediatrics at Washington University in St. Louis and director of pediatric cardiac electrophysiology at St. Louis Children's Hospital, where she leads the largest pediatric electrophysiology program in the midwest. Dr. Avari Silva has published numerous papers bringing new technologies to pediatric patients.

Berk Tas is CEO and president of SentiAR. He has led development of emerging technologies and companies in Fortune 500, private equity, venture capital funded and privately held organizations.

For more MDedge Podcasts, go to mdedge.com/podcasts

Email the show: [email protected]

Interact with us on Twitter: @MDedgeCardio

Novel cardiac troponin protocol rapidly rules out MI

Three-quarters of patients who presented with suspected acute coronary syndrome were safely discharged from ED without hospital admission.

Study questions preemptive TEVAR for extended type A dissections

Interim results from a single-center study show that preemptive TEVAR may not be necessary for type A aortic dissections.

TAVR, SAVR share same infective endocarditis risk

Be aware, be careful, and provide appropriate antibiotic prophylaxis, just as surgeons do in SAVR.

Moderate aortic stenosis just as deadly as severe AS

The current echocardiographic definition of moderate aortic stenosis may greatly underestimate risk.

For more MDedge Podcasts, go to mdedge.com/podcasts

Email the show: [email protected]

Interact with us on Twitter: @MDedgeCardio

Smoking and inactivity are the most powerful lifestyle risk factors after an MI

Insufficient activity beats out obesity or above-target LDL cholesterol.

Ticagrelor monotherapy tops DAPT for high-risk PCI patients

TWILIGHT findings support move to shorter dual-antiplatelet therapy.

Panel releases guidelines for red meat, processed meat consumption

"This assessment may be excessively pessimistic; indeed, we hope that is the case."

Remember that preeclampsia has a 'fourth trimester'

Delivering the baby doesn't always cure the hypertension.

For more MDedge Podcasts, go to mdedge.com/podcasts

Email the show: [email protected]

Interact with us on Twitter: @MDedgeCardio

Cardiology dead last as women's IM subspecialty choice

Women in internal medicine residencies were more likely than men to report that they had never considered cardiology as a career choice.

Beta-blockers effective, safe for HFrEF with renal dysfunction

Their role is solidified for essentially all such heart failure patients, regardless of their renal function.

Heart failure score derived from machine learning predicts risk in diabetes patients

Highest WATCH-DM scores linked to 5-year heart failure risk approaching 20%.

Daily polypill lowers BP, cholesterol in underserved population

The regimen's simplicity and low cost may overcome barriers to treatment.

For more MDedge Podcasts, go to mdedge.com/podcasts

Email the show: [email protected]

Interact with us on Twitter: @MDedgeCardio

Prasugrel bests ticagrelor in ACS in surprise findings

ISAR-REACT 5 was the first-ever direct head-to-head look at two potent P2Y12 inhibitors in this setting.

European cholesterol guidelines push LDL targets below 55 mg/dL

PCSK-9 inhibitors are elevated to a top-tier recommendation in very-high-risk patients.

Drug doses for heart failure could possibly be halved for women

Women reached the highest level of drug efficacy at half the doses of ACE inhibitors or ARBs and beta-blockers.

Post-MI angina in stable patients flags high risk

The angina finding should immediately influence practice, expert says.

For more MDedge Podcasts, go to mdedge.com/podcasts

Email the show: [email protected]

Interact with us on Twitter: @MDedgeCardio

MDedge reporters discuss the latest in practice-changing data from the 2019 annual congress of the European Society of Cardiology in Paris.

Join Mitchel L. Zoler, Bruce Jancin, Kari Oakes, and MDedge Cardiology editor Catherine Hackett as they discuss what they reported from the annual meeting.

We introduce a brand new format with Jerome Dwyer, MD, brother of our host, Jim Dwyer, MD, for a new segment that we're calling 'Card Talk' where Dr. Jim and Dr. Jerry talk about the current clinical state of cardiology and take a peek into the future.

This week in cardiology news:

• Survival at 'overweight' BMI surpasses 'normal'Data from more than 142,000 middle-aged people worldwide show those with a BMI of 25-29 outlast those at 20-24.
• Visceral fat linked to sixfold increase in masked hypertensionThe body mass index trend was not significant. New class of drug safely halved LDL cholesterol in ORION-11Inclisiran potently cut LDL cholesterol by inhibiting the PCSK9 enzyme with biannual injections.

DAPA-HF results transform dapagliflozin from antidiabetic to heart failure drug

Proof that dapagliflozin significantly helped heart failure patients without diabetes recategorizes the drug as a major agent for treating heart failure.

New hypertension cases halved with community-wide salt substitution

Social marketing principles achieved near-universal salt replacement, village by village, in rural Peru.

Ticagrelor: Modest benefit, bigger bleed risk in diabetes plus stable CAD

Patients with prior PCI fared a bit better and may be a target population for long-term DAPT therapy.

In PAD, dropping statins ups death risk 43%

Statin adherence saves lives in peripheral arterial disease.