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Dr. Michael Koren joins Kevin Geddings to explain what "Phase 1" means in the context of clinical research. The doctor talks about how phase 1 is the first time a new investigational treatment is used in a person, but that there is an enormous amount of work that happens before a medication gets to that point. He also discusses the other phases of research, concerns about safety, and why clinical research is so important.

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Dr. Noelle Pomeroy, PhD, joins Dr. Erich Schramm to discuss mental health, particularly from the perspective of relationships. The two discuss the value of therapy and the importance of talking with an expert in areas that are new to us, and then get into sexual health and relationships. They talk through the changes that happen as people age, the challenges that pornography can create for chronic users, and how intimacy can change over the life of a relationship. Dr. Pomeroy then gives practical advice for couples on sex, nonsexual intimacy, and the importance of communication.

Visit Noelle Pomeroy on the web at https://jax-therapy.com/

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Have a question for Dr. Koren? Email him at [email protected]

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Dr. Michael Koren joins Kevin Geddings to discuss atrial fibrillation. This heart condition is caused by rapid, irregular heartbeats originating in the upper chambers and is a critical risk factor for strokes. Dr. Koren talks about the current standard-of-care medicines for atrial fibrillation, blood thinners, and  their shortcomings. He finishes with an explanation of how clinical trials are looking for new ways to lower the risk of stroke in those with atrial fibrillation with a better side effect profile than current blood thinners.

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Dr. Paul Miller joins Dr. Michael Koren to discuss ongoing research in the field of psychology. Dr. Miller expounds on the complex interplay between genetic predisposition, trauma, and the way the brain misprocesses memory, and the potential negative psychological outcomes. Dr. Miller then discusses treatments and the changing treatment landscape, including techniques that mimic rapid eye movement (REM) sleep to help process memories in a less traumatic way, and newer medications under investigation that may help people who have traditionally had trouble with current therapies.

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Dr. Michael Koren joins Kevin Geddings to give some advice on easy-to-accomplish resolutions for the new year. The doctor gives three resolutions:

1. Get an advanced cholesterol Lp(a) check
2. Get a fatty liver test
3. Do an Alzheimer's screening

These are easy resolutions that can help guide health decisions for the year and beyond.

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Javonte Maynor joins Dr. Erich Schramm to talk about Mr. Maynor's journey from Division I basketball to starting and running a clinical research site. The entrepreneur talks about his passion for clinical research, representation, and how historically low representation of minorities is a design choice which can be remedied. The duo discusses methods of increasing diversity, trust, and good patient outcomes and how those three ideas are intrinsically linked. They finish the conversation by talking about a shared interest, medical cannabis and the slow movement towards more natural medicines.

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Dr. Heather Luing joins Dr. Michael Koren to talk about depression. They discuss what it can feel like, why December is associated with a spike in depression cases, and what's going on inside the body and brain that makes this disorder so challenging. The duo of doctors also explore new and emerging medications in the depression field, including several that target completely new pathways in the brain and may provide relief for people who have not found help with older medications. Dr. Luing also talks about the importance of talk therapy.

The doctors heavily emphasize a relatively new resource for urgent mental help, the 988 Mental Health Crisis Line.

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Dr. Michael Koren joins Kevin Geddings to answer the question: What does it mean to be medically ready for the holidays. The doctor discusses how the holidays are fun, but changes in schedules can throw off precise medical routines. The doctor explains that people need to plan around limited pharmacy hours, dietary challenges, and risks of excessive alcohol consumption. As long as you are prepared, you're medically ready for the holidays!

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There's not a lot that we both need to do and get paid to do. Dr. Michael Koren joins Kevin Geddings to discuss one of the most beneficial parts of clinical research: getting paid to do what you should be doing anyway. As an example, the doctor talks about Lp(a), a really, really, really, really bad cholesterol that increases the chances of having a heart attack and stroke. Dr. Koren explains that most people haven't had an Lp(a) test done because traditional cholesterol medications don't lower this really bad form of LDL, but that people canget an Lp(a) test done at a research center, get paid for their time and travel, and may even be referred to an Lp(a) lowering study if their numbers are high.

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Dr. Zeke Emanuel joins Dr. Michael Koren to discuss his new book Eat Your Ice Cream: Six Simple Rules for a Long and Healthy Life. Dr. Emanuel explains how frustrated he is at trendy, influencer-style health advice and how it accentuates intense, short-term "miracle fixes," which are almost always for sale and rarely have medical benefits. He explains his philosophy, and the philosophy of Benjamin Franklin: that, in order to make substantive change, you have to focus on one thing at a time, developing it into a habit. Dr. Emanuel also explains the title of his book, that one of the largest and most important factors in health is social well-being.

Preorder Dr. Emanuel's book here: https://www.barnesandnoble.com/w/eat-your-ice-cream-ezekiel-j-emanuel-md/1147402755

Be a part of advancing science by participating in clinical research.

Have a question for Dr. Koren? Email him at [email protected]

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