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Dr. Michel Koren and Dr. Mitchell Rothstein host a presentation in front of a live audience to discuss the current state of gene editing. The doctoral duo discuss developments including new-to-market medical therapies, clinical trials, and the legal issues surrounding gene therapy patents. They also explain the difference between gene silencing techniques, which temporarily stop genes from creating proteins, and gene editing techniques which permanently alter the genome. They also touch on controversies, risks, and the comprehensive considerations that take place before a participant can partake in a gene editing clinical trial.

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Dr. Robin Blackstone joins Dr. Mitchell Rothstein to talk about the intersection of technology, empathy, and the healthcare system. The doctoral duo discuss the emerging role of AI in healthcare and how specialized, individualized, non-chatbot systems may be able to sift through the masses of health data that plague doctors to provide individualized, patient-specific recommendations and revelations. The two also briefly discuss the history of healthcare in order to present Dr. Blackstone's vision for the future, Health 4.0. They finish the discussion with more details about Dr. Blackstone's Public Benefit Corporation, The H4 Alliance Trust, a 5013c project focusing on a person-centered health system. Find more about the H4 Alliance Trust at h4alliancetrust.org

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Join internist and cholesterol expert Albert Lopez, DO, FACP, FASPC, as he reviews the new 2026 Cholesterol Guidelines. In this segment, he focuses on new risk assessment guidelines, including the genetic risk factor Lipoprotein(a) and a sign of damage, the CAC score, and the recommendation that risk assessment starts much younger, around 30 years old. He discusses treatment options for high cholesterol, including sound evidence for statins and newer treatments for rare cholesterol manifestations.

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Have a question for Dr. Koren? Email him at [email protected]

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Allergist and immunologist Dr. Steve Dorman joins Dr. Michael Koren to discuss the causes, complications, and carousel of chronic cough. Dr. Dorman reviews what chronic cough is and how it may be due to anatomical changes, acid reflux, allergies, and so on. Because of this, the doctor explains, sufferers of cough may end up going around the "carousel" of chronic cough, where they end up seeing their primary care specialist, a GI doctor, an Ear, Nose & Throat (ENT) specialist, pulmonary physicians, and an allergist and immunologist like himself. The duo then tackle what can be done, from medications, new research, and non-medicinal treatments.

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OBGYN Dr. Richard Myers joins Dr. Erich Schramm to discuss the name change from Polycystic Ovarian Syndrome (PCOS) to Polyendocrine Metabolic Ovarian Syndrome (PMOS). This syndrome is the combination of three parts: increased polyendocrine hormones (like insulin and androgens), changing metabolism, and differences in ovarian function Dr. Myers explains that the name change to PMOS reflects the changing understanding and focus of the syndrome from a purely ovarian-centered approach to a more holistic, full-body treatment regimen. The doctors also discuss how different patient desires drive different treatment options and the need for individualized, patient-centered care. They finish by looking at new treatments, including GLP-1 and GIP medications that can help address the underlying metabolic components of the PMOS.

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Dermatologist Dr. Michael Bernhardt joins Dr. Mitchell Rothstein to discuss the rapidly changing and improving world of chronic skin condition. The two doctors discuss the correlation between chronic skin conditions and allergies, and the role that inflammation play in both. The docs then dive deep into our inflammation system.

This informs the next section of the podcast, where the Drs. Bernhardt and Rothstein talk about the landscape of chronic skin condition medications. They explain that these conditions had poor outcomes and ineffective medicines for decades, and that this picture has only changed in the last 4-5 years with new medications that work from the inside out instead of the outside in. They talk about new generations of medication that target the inflammatory signals themselves inside the body, showing rapid relief to otherwise untreatable conditions. They finish with a brief look at what is coming down the pipeline of clinical trials.

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Nearly a decade after the last major cholesterol guidelines were released, the new 2026 Multi-Specialty Lipid Guidelines introduce significant changes in how cardiovascular risk is assessed and managed. In this episode, Albert Lopez, DO, FACP, FASPC, explains why LDL cholesterol treatment goals have returned, how newer markers such as ApoB and Lipoprotein(a) are reshaping risk assessment, and why earlier, more aggressive treatment may help reduce the world's leading cause of death, cardiovascular disease.

Dr. Al Lopez, DO,  discusses the role of statins, non-HDL cholesterol, triglycerides, genetic cholesterol disorders, screening recommendations for children and older adults, and the importance of a team-based approach to prevention. Whether you're a healthcare professional or someone interested in protecting your heart health, this episode provides a practical overview of the latest evidence-based recommendations for preventing heart disease.

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In this episode of MedEvidence, host Dr. Michael Koren speaks with epidemiologist Dr. Hannah Gardener about how everyday exposures may influence long-term health outcomes.

Dr. Gardener shares her journey from neuroscience and epidemiology training at Harvard to her current work studying stroke, dementia, and environmental risk factors. She explains how personal life experiences sparked her interest in environmental health and led her to examine how early-life and daily exposures can shape disease risk across the lifespan.

The conversation explores her research on diet soda consumption and its surprising associations with vascular outcomes, including stroke, heart disease, and cognitive decline. She breaks down what “prospective cohort studies” really mean and how to interpret findings without overgeneralizing results.

The discussion then expands to PFAS, often called “forever chemicals”, which are widely used in consumer products and persist in the environment and human body. Dr. Gardener explains where these chemicals are found, what health effects have been observed in the research, and practical, evidence-based strategies individuals can use to reduce exposure.

This episode offers a thoughtful, research-driven look at how environmental factors, diet choices, and chemical exposures intersect with long-term brain and cardiovascular health—and what can realistically be done today to reduce risk.

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What do island-hopping physicians, aviation safety, sleep medicine, and nasal polyps have in common? Dr. Adam Shapiro.

In this episode of the MedEvidence Podcast, Dr. Michael Koren sits down with ENT specialist and sleep medicine expert Dr. Adam Shapiro to discuss his remarkable career practicing medicine in the U.S. Virgin Islands, commuting between islands as a pilot, and helping aviation professionals manage fatigue-related health issues.

The conversation then shifts to a practical masterclass on nasal polyps and sinus health. Dr. Shapiro explains what nasal polyps are, why they develop, how they affect breathing and sleep, and the latest minimally invasive treatment options available today. He also discusses the connection between nasal health, sleep apnea, chronic sinus problems, ear pressure issues, and overall quality of life.

Whether you're struggling with chronic congestion, sleep problems, recurrent sinus infections, or simply curious about the latest advances in ENT care, this episode offers expert insights and evidence-based guidance.

If you found this helpful, subscribe to MedEvidence and share the episode with someone who’s always congested.

Be a part of advancing science by participating in clinical research.

Have a question for Dr. Koren? Email him at [email protected]

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What happens when a Harvard-trained psychiatrist follows the evidence beyond traditional medicine?

In this episode of MedEvidence, Dr. Michael Koren sits down with Dr. Carol Locke, physician entrepreneur and Chief Science Officer of OmegaBrite, to explore her remarkable journey from psychiatry and academic research at Harvard’s McLean Hospital to pioneering evidence-based omega-3 innovation.

Dr. Locke shares how clinical research into mood disorders led to surprising discoveries about omega-3 fatty acids, brain health, inflammation, stress response, and emotional resilience. Together, they break down the science behind omega-3 balance, the role of EPA and DHA, third-party testing, and what clinical trials reveal about omega-3 supplementation’s impact on mood, anxiety, inflammation, and overall wellness.

You’ll also hear insights on physician entrepreneurship, innovation in nutraceutical science, and why evidence-based quality matters when choosing supplements.

In this episode:

•  How omega-3s influence brain function and mood 
•  The link between inflammation, stress, and mental health 
•  What clinical trials reveal about omega-3 supplementation 
•  Why supplement purity and testing matter 
•  Emerging science on omega-3 delivery to the brain 
•  Advice for physicians pursuing innovation 

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Have a question for Dr. Koren? Email him at [email protected]

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