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Dr. Michael Koren joins Kevin Geddings to discuss some of the pitfalls of traditional healthcare in America and how clinical research can bridge those gaps. The doctor and clinical researcher talks about a family member recieving care in a world-class medical facility, and that even in this setting there is confusion about who is coordinating the patient's care. He contrasts this experience with clinical research, where there are fewer patients and protocol-specified individuals who are required to keep the patient front-of-mind and take charge of medical care.

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Dr. Evan Loh joins Dr. Michael Koren to discuss Dr. Loh's journey through the medical profession. Dr. Loh moved from doing lab work in medical school to patient care in the academic sphere and into the pharmaceutical world of research. Dr. Loh and Dr. Koren discuss the core differences between bedside physican work and research, including in time spent with patients, physician incentives, and the treatment that results. Through it all the doctors find a simple axiom: all medicine is about patients at the end of the day.

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Dr. Koren joins Kevin Geddings to report live from the American Heart Association meeting in New Orleans with fresh results on LDL lowering, prevention, and the future of gene editing for cholesterol. They discuss the excitement of big meetings like the AHA and how results can even surprise the investigators that were working on a study.

Note: Dr. Koren refers to CRISPR Therapeutics, a company developing gene-based cholesterol lowering technologies. CRISPR-Cas9 is also the general name of a gene editing technique.

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Pediatrician and environmental scientist Dr. Deborah Hendrickson joins Dr. Michael Koren to discuss how the environment affects our health. Dr. Hendrickson uses the example of poor air quality from sources such as wildfires and pollution to explain how this impacts children's breathing, from lung development to allergies and asthma. She also notes that the climate is changing due to human causes, which should inspire hope that human solutions are possible. The doctors conclude by discussing how climate change is making things more difficult everywhere and how the risks to our children, in particular, are increasing.

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Dr. Michael Koren joins Kevin Geddings to discuss the current state of COVID vaccines and research. The cardiologist weighs the real risks and benefits of COVID vaccines, focusing on who may need protection the most and who might be able to skip this year's booster. Dr. Koren also talks about the new prescription mandate for COVID vaccines, and how joining a clinical trial may help some people clear that burden more easily.

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Urologist Dr. Yaw Nyame joins Dr. Michael Koren to discuss bladder and prostate cancers. Dr. Nyame talks about his journey through college - including the choice between rock stardom and medical school - and how he got to the Fred Hutch Cancer Center in Seattle. Dr. Nyame explains symptoms, the history, and treatments for prostate and bladder cancer. He tells us "if you have blood in the urine, you definitely want to get to your primary care doctor." He also expands on gaps in cancer outcomes for Black men. Along the way, we weigh benefits and harms of PSA screening and talk honestly about sexual health after treatment.

Show Note: Lynch syndrome is a genetic condition also known as hereditary nonpolyposis colorectal cancer (HNPCC). It represents an increased risk of several cancers, including colorectal, endometrial, gastric, ovarian, and pancreatic cancer. It is caused by an error in the DNA mismatch repair mechanism, which normally corrects for random insertions into the DNA code.

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Cardiologist Dr. Koren joins Kevin Geddings to talk about the importance of understanding what we know about patients. The cardiologist recounts a recently recorded podcast where he - with full consent - reviewed the cardiovascular infomation of a patient to give a broader understanding of what all of the numbers mean and how they can give doctors and patients insight into what's going on. Dr. Koren then makes an offer to do this for other patients to help illuminate other medical areas with experts in those fields - right here on MedEvidence!

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Dr. Jill Grimes joins Dr. Erich Schramm to discuss young adult health, covering topics from teens and college students to those just starting life on their own. They discuss her book, The Ultimate College Student Health Handbook, and the evidence-based advice Dr. Grimes shares to help students navigate the healthcare system confidently.

From practical tips like keeping a photo of your insurance card on your phone to knowing what to tell your doctor at the start of a visit and what to ask before you leave, this episode covers real-world lessons every young adult should know. The doctors also dive into important privacy questions, including who can access your medical information when you’re still on your parents’ insurance.

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Dr. Michael Koren joins Kevin Geddings to discuss advances in brain imaging technology. The doctor opens with a fun story about a breakup in college, then moves to discuss how brain imaging for Alzheimer’s may move from noisy tunnels to a dentist-chair-like apparatus for easier scanning in a smaller space. The duo brings it together with the benefits of clinical research and how those who participate may get access to the newest technologies.

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Dr. Reza Bolouri, a memory expert, joins Dr. Michael Koren to discuss Alzheimer’s, what it is, the risks, how it differs from other forms of dementia. The doctors also explore how treatment of dementia has evolved and progressed over the years from symptomatic treatments to new, disease-modifying medications that can slow the progression of Alzheimer’s. They also talk about how clinical trials are exploring the next generation of Alzheimer’s medications and tests which may provide preventative solutions to stop the disease before it even starts.

Be a part of advancing science by participating in clinical research.

Have a question for Dr. Koren? Email him at [email protected]

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