Sam Guglani in discussion with Colin Leys, Richard Horton, Clare Short and Matthew Flinders on the HNS, equality, health and the broader social determinants of health that may go unaddressed. Have the values that created the NHS changed, and are we handing over the NHS to organisations that are, in Colin Leys' words "not dedicated to community interests but to shareholder interests"?

Ray Tallis and Rupert Sheldrake discuss the limitations of reason, the dogma of science and the evolution of knowledge in medicine.

Sam Guglani talks to Ray Tallis, Iona Health, Gabriel Scally and Sean Elyan about how medicine is communicated, the hiatus of understanding of the patient context and the erosion of trust in medicine and medical professionals.

Rupert Sheldrake, author of 'The Science Delusion', talks about scientism, the conflict between science as a belief system and science as method of enquiry, and the 10 dogmas of modern science. Rupert challenges us to question our beliefs about the scientific worldview - and what might result if we did.

Questions from the Medicine Unboxed audience for Sebastian Faulks on lies and fiction in the medical encounter, his account of mental illness in 'Human Traces', the character of Stephen in 'Birdsong' and narrative and storytelling in consultation.

What is the imagination for? Sam Guglani and Jo Shapcott explore cracks in the edifice of reason, and what new ways we can understand the imagination. Jo draws on her experience of her own illness and how the imagination works with a diagnosis of serious illness - her "cellular imagination".

John Burnside talks to Sam Guglani and Jo Shapcott about metaphor and imagination and its force in the world. We hear John reads his poem "First Signs of Ageing" via Soundcloud.

Questions from the audience for Jo Shapcott: should imagination be prescribed, metaphor and the collective imagination, empathy and imagination as core clinical values, the roll of poetry in medical education and why hypotheses don't arrive from heaven.

Charles Fernyhough on the 'rush to the neuro' in the popular press, can neuroscience can explain the human experience, if there is such a thing as neurotruth - and how it might affect the way we see ourselves.

"I am my body. I am not my body." So begins Tim Parks at Medicine Unboxed 2012 on his experience of illness, treatment and medicine and his experience of mortal life.