When working as a fly fishing guide, Dr Eagle met the mentor who changed his life and paid for his medical training. He tells Dr Magnus Ohman how this lucky encounter inspired a life of philanthropy.

Cerebral microinfarcts, reduced-dose NOACs, quadpill for hypertension, and inappropriate ICD shocks are topics discussed by Dr John Mandrola in this week's podcast.

Drs Sandhu, Bell and Gulati discuss NORSTENT, LEADERS FREE, and the disappointing data on bioresorbable scaffolds.

Calcium scores, NOAC usage, the Mediterranean diet, AF hospitalization outcomes, and waist-to-hip ratio and genetic predisposition to type 2 diabetes and CHD are discussed in this week's podcast.

Do exercise intensity and sport type affect mortality risk or is it all the same? Dr JoAnn Manson reviews two recent studies on physical activity that have important public health implications.

Mobility and BP, rivaroxaban for MACE prevention, alirocumab safety, brain injury after LV ablation, and texting for patient care are the topics discussed by Dr John Mandrola in this week's podcast

Stuart Pocock reviews 12 key considerations when the outcome of a clinical trial is negative, using familiar trials to illustrate these points. Can the data be salvaged, or is it a 'no-hoper'?

Dr Gregg Stone reviews the questions to ask before accepting the results of a 'positive' clinical trial.

Dr Egbe leads an expert panel covering the key treatment strategies in treating atrial and ventricular arrhythmias in congenital heart disease patients.

FDA approval of CardioInsight, red flags on vascular-closure device, morbidity in older ICD patients, US vs non-US trained physicians, and top-line findings from the FOURIER PCSK9 inhibitor study.