Dr Sandhu illustrates strategies for diagnosing and treating intractable angina using two complex case studies in a discussion with Dr Widmer.

Drs Harrington and Hernandez discuss the inefficiencies of the US clinical trial system and their involvement in the National Patient-Centered Clinical Research Network's first trial on aspirin dose.

AF ablation in persistent AF, complete vs IRA-only revascularization in STEMI, ICDs in women, measuring BP, and a heart-disease moon shot are discussed by Dr John Mandrola in this week's podcast.

Long-QT overdiagnosis and overtreatment, exercise and AF, the athlete's heart, statin eligibility in primary prevention, and cardiac imaging are discussed in this week's podcast.

Dr Amy Pollak talks to Dr William Haley of the Mayo Clinic about how to interpret the results from the SPRINT trial and why practitioners should stay tuned for further results.

Regional variation in therapeutic decision-making and clinical practice prompts Dr O'Donoghue to question what affects her choices.

Drs Harrington and Gibson give their annual review of the highs and lows in medicine with a focus on cardiology.

Dr JoAnn Manson urges clinicians to consider physical activity as a 'vital sign.'

Mechanical vs bioprosthetic aortic-valve replacement, lack of data for patients with heart and kidney disease, optimism post-ACS, and statin use are discussed by Dr Mandrola in this week's podcast.

Two analyses support long-term anticoagulation in patients with VTE. Dr Goldhaber expects the benefits to outweigh the risks in the NOAC era.