Medscape InDiscussion: Gout

Drs Ken Saag and Hyon Choi examine the rising burden of gout, key population risk factors, medication effects, and opportunities to close persistent treatment gaps.

Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/ca8/p04/podcast-gout-s1-ep3-2026a1000qek. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Gout and Pseudogout https://emedicine.medscape.com/article/329958-overview

Global, Regional, and National Burden of Gout, 1990-2020, and Projections to 2050: A Systematic Analysis of the Global Burden of Disease Study 2021 https://pubmed.ncbi.nlm.nih.gov/38996590/

Trends in Prevalence of Gout Among US Asian Adults, 2011-2018 https://pubmed.ncbi.nlm.nih.gov/37083663/

Rheumatoid Arthritis (RA) https://emedicine.medscape.com/article/331715-overview

Gout Management in Patients With CKD: A Review https://pubmed.ncbi.nlm.nih.gov/40609855/

Dietary and Lifestyle-Centered Approach in Gout Care and Prevention https://pubmed.ncbi.nlm.nih.gov/34196878/

Impact of Alcohol Consumption on Hyperuricemia and Gout: A Systematic Review and Meta-analysis https://pubmed.ncbi.nlm.nih.gov/40463472/

Beer, Liquor, and Wine Consumption and Serum Uric Acid Level: The Third National Health and Nutrition Examination Survey https://pubmed.ncbi.nlm.nih.gov/15593346/

Alcohol Consumption as a Trigger of Recurrent Gout Attacks https://pubmed.ncbi.nlm.nih.gov/16945617/

Effects of Dietary Factors on Hyperuricaemia and Gout: A Systematic Review and Meta-analysis of Observational Studies https://pubmed.ncbi.nlm.nih.gov/39289820/

Is There a Role for Cherries in the Management of Gout? https://pubmed.ncbi.nlm.nih.gov/31205513/

Cherry Consumption and Decreased Risk for Recurrent Gout Attacks https://pubmed.ncbi.nlm.nih.gov/23023818/

Lowering and Raising Serum Urate Levels: Off-Label Effects of Commonly Used Medications https://pubmed.ncbi.nlm.nih.gov/35787862/

Environmental Triggers of Hyperuricemia and Gout https://pubmed.ncbi.nlm.nih.gov/36333002/

Elevated Blood Lead Levels Associated With Illicitly Distilled Alcohol—Alabama, 1990-1991 https://pubmed.ncbi.nlm.nih.gov/1565093/

SGLT2 Inhibitors vs Sulfonylureas for Gout Prevention Among Patients With Type 2 Diabetes Receiving Metformin https://pubmed.ncbi.nlm.nih.gov/38619822/

Newer Glucose-Lowering Drugs and Risk for Gout: A Network Meta-Analysis of Randomized Outcomes Trials https://pubmed.ncbi.nlm.nih.gov/38796335/

Asymptomatic Hyperuricemia. Risks and Consequences in the Normative Aging Study https://pubmed.ncbi.nlm.nih.gov/3826098/

Serum Urate and Recurrent Gout https://pubmed.ncbi.nlm.nih.gov/38319333/

Association Between Gout Flare and Subsequent Cardiovascular Events Among Patients With Gout https://pubmed.ncbi.nlm.nih.gov/35916846/

Cardiovascular Safety of Febuxostat or Allopurinol in Patients With Gout https://pubmed.ncbi.nlm.nih.gov/29527974/

Trends in Gout and Rheumatoid Arthritis Hospitalizations in the United States, 1993-2011 https://pubmed.ncbi.nlm.nih.gov/27272587/

The Design of a Randomized Controlled Active Comparator Strategy Trial for Gout: Treat to Target Serum Urate Vs Treat to Avoid Symptoms https://pubmed.ncbi.nlm.nih.gov/40126890/

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Drs Kenneth Saag and Nicola Dalbeth explore how crystal analysis and imaging advances can sharpen gout diagnosis and guide patient care.

Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/ca8/p04/podcast-gout-s1-ep2-2026a1000qej. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Gout and Pseudogout https://emedicine.medscape.com/article/329958-overview

2015 Gout Classification Criteria: An American College of Rheumatology/European League Against Rheumatism Collaborative Initiative https://pubmed.ncbi.nlm.nih.gov/26352873/

Clinical Features and Recurrent Attack in Gout Patients According to Serum Urate Levels During an Acute Attack https://pubmed.ncbi.nlm.nih.gov/30685959/

Gout on the Acute Medical Take https://pubmed.ncbi.nlm.nih.gov/40436276/

Psoriatic Arthritis https://emedicine.medscape.com/article/2196539-overview

Rheumatoid Arthritis (RA) https://emedicine.medscape.com/article/331715-overview

Synovial Fluid Analysis: Relevance for Daily Clinical Practice https://pubmed.ncbi.nlm.nih.gov/37429800/

Advanced Imaging Techniques in Crystal Arthritis https://pubmed.ncbi.nlm.nih.gov/39906218/

Ultrasound Features in Gout: An Overview https://pubmed.ncbi.nlm.nih.gov/39189200/

Dynamic Assessment of the Double Contour Sign by Ultrasonography Helps to Distinguish Between Gout and Calcium Pyrophosphate Deposition Disease https://pubmed.ncbi.nlm.nih.gov/36927850/

Test Characteristics of Raman Spectroscopy Integrated With Polarized Light Microscopy for the Diagnosis of Acute Gouty Arthritis https://pubmed.ncbi.nlm.nih.gov/37442334/

Dual-energy CT Applications in Musculoskeletal Disorders https://pubmed.ncbi.nlm.nih.gov/38291893/

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Drs Ken Saag and Michael Pillinger explore the chicken-or-egg question connecting gout with cardiovascular, kidney, and metabolic conditions.

Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/ca8/p04/podcast-gout-s1-ep1-2026a1000qeh. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Gout and Pseudogout https://emedicine.medscape.com/article/329958-overview

Gout: Global Epidemiology, Risk Factors, Comorbidities and Complications: A Narrative Review https://pubmed.ncbi.nlm.nih.gov/39702222/

The Fifth Element: Is Vascular Dysfunction an Intrinsic Feature of Gout? https://pubmed.ncbi.nlm.nih.gov/40021439/

Hyperuricemia Induces a Primary Renal Arteriolopathy in Rats by a Blood Pressure-Independent Mechanism https://pubmed.ncbi.nlm.nih.gov/11997315/

The Environment and Disease: Association or Causation? https://pubmed.ncbi.nlm.nih.gov/14283879/

Effect of Allopurinol on Blood Pressure of Adolescents With Newly Diagnosed Essential Hypertension: A Randomized Trial https://pubmed.ncbi.nlm.nih.gov/18728266/

Expert Consensus and Evidence-Based Recommendations for the Assessment of Flow-Mediated Dilation in Humans https://pubmed.ncbi.nlm.nih.gov/31211361/

Reading Mendelian Randomisation Studies: A Guide, Glossary, and Checklist for Clinicians https://pubmed.ncbi.nlm.nih.gov/30002074/

Effects of Allopurinol on the Progression of Chronic Kidney Disease https://pubmed.ncbi.nlm.nih.gov/32579811/

Pegloticase Treatment Significantly Decreases Blood Pressure in Patients With Chronic Gout https://pubmed.ncbi.nlm.nih.gov/31079535/

Treat-to-Target Urate-Lowering Treatment and Cardiovascular Outcomes in Patients With Gout https://pubmed.ncbi.nlm.nih.gov/41587055/

Risk of Venous Thromboembolism With Gout Flares https://pubmed.ncbi.nlm.nih.gov/36808284/

Cardiovascular Events in Patients With Gout Initiating Urate-Lowering Therapy With or Without Colchicine for Flare Prophylaxis: A Retrospective New-User Cohort Study Using Linked Primary Care, Hospitalisation, and Mortality Data https://pubmed.ncbi.nlm.nih.gov/39708831/

Comparative Cardiovascular Safety of Nonsteroidal Anti-Inflammatory Drug Versus Colchicine Use When Initiating Urate-Lowering Therapy Among Patients With Gout: Target Trial Emulations https://pubmed.ncbi.nlm.nih.gov/40415645/

Uric Acid as a Risk Factor for Chronic Kidney Disease and Cardiovascular Disease - Japanese Guideline on the Management of Asymptomatic Hyperuricemia https://pubmed.ncbi.nlm.nih.gov/33342914/

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