Join Drs Forest Arnold and Brittanie West as they discuss their personal experience preventing and managing RSV in adults in their Appalachian communities.

Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/viewarticle/998284. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Respiratory Syncytial Virus Infection https://emedicine.medscape.com/article/971488-overview

RSV in Rural Communities: Lessons From Appalachia https://www.medscape.com/viewarticle/985982

CDC RSV Surveillance and Research https://www.cdc.gov/rsv/research/index.html

American Hospital Association Rural Report rural-report-2019.pdf (aha.org) https://www.aha.org/system/files/2019-02/rural-report-2019.pdf

Physician Learning Preferences physician-learning-report-2022.pdf (doximity.com) https://press.doximity.com/reports/physician-learning-report-2022.pdf

Do You Spend More Time Searching for Medical Information Than the Average American? https://swnsdigital.com/us/2020/11/do-you-spend-more-time-searching-for-medical-information-than-the-average-american/

One Assay to Test Them All: Multiplex Assays for Expansion of Respiratory Virus Surveillance https://pubmed.ncbi.nlm.nih.gov/37168265/

Respiratory Syncytial Virus Hospitalization Surveillance Network (RSV-NET) https://www.cdc.gov/rsv/research/rsv-net/index.html

RSVVaxView https://www.cdc.gov/vaccines/imz-managers/coverage/rsvvaxview/index.html

REVIRAL 1 https://www.hra.nhs.uk/planning-and-improving-research/application-summaries/research-summaries/reviral-1/

A Randomized, Placebo-Controlled, Respiratory Syncytial Virus Human Challenge Study of the Antiviral Efficacy, Safety, and Pharmacokinetics of RV521, an Inhibitor of the RSV-F Protein https://pubmed.ncbi.nlm.nih.gov/31712214/

Join Drs Forest Arnold and Angela R. Branche as they discuss the epidemiology of RSV, the importance of an accurate diagnosis, treatment options, cohorting, and risk factors.

Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/viewarticle/998283. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Respiratory Syncytial Virus Infection https://emedicine.medscape.com/article/971488-overview

Seasonality of Respiratory Syncytial Virus — United States, 2017–2023 https://www.cdc.gov/mmwr/volumes/72/wr/mm7214a1.htm

Rates of Medically Attended RSV Among US Adults: A Systematic Review and Meta-analysis https://pubmed.ncbi.nlm.nih.gov/35873302/

Multicenter Evaluation of the Cepheid Xpert Xpress SARS-CoV-2/Flu/RSV Test https://pubmed.ncbi.nlm.nih.gov/33298613/

Comparative Analysis of Three Multiplex Platforms for the Detection of Respiratory Viral Pathogens https://pubmed.ncbi.nlm.nih.gov/36099751/

Centers for Disease Control and Prevention: Respiratory Syncytial Virus (RSV) https://www.cdc.gov/rsv/index.html

Join Drs Forest Arnold and Hannah Nam as they discuss preventing RSV outbreaks within healthcare facilities, and strategies to minimize RSV transmission among healthcare workers and patients.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/998282). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Respiratory Syncytial Virus Infection https://emedicine.medscape.com/article/971488-overview

Respiratory Syncytial Virus Hospitalization Surveillance Network (RSV-NET) https://www.cdc.gov/rsv/research/rsv-net/index.html

CDC – Respiratory Syncytial Virus (RSV) Vaccination Coverage and Intent for Vaccination, Adults 60 Years and Older, United States https://www.cdc.gov/vaccines/imz-managers/coverage/rsvvaxview/adults-60-coverage-intent.html

CDC - Healthcare Providers: RSV Vaccination for Adults 60 Years of Age and Over https://www.cdc.gov/vaccines/vpd/rsv/hcp/older-adults.html

Respiratory Syncytial Virus (RSV) Vaccine, Adjuvanted (Rx) – Arexvy https://reference.medscape.com/drug/arexvy-respiratory-syncytial-virus-rsv-vaccine-adjuvanted-4000359

Respiratory Syncytial Virus (RSV) Vaccine (Rx) – Abrysvo https://reference.medscape.com/drug/abrysvo-respiratory-syncytial-virus-rsv-vaccine-4000347

Join Drs Forest Arnold and Christopher Robinson as they discuss long-term outcomes of severe RSV infection in adults.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/998281). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Respiratory Syncytial Virus Infection https://emedicine.medscape.com/article/971488-overview

Neurologic Manifestations of Severe Respiratory Viral Contagions https://pubmed.ncbi.nlm.nih.gov/32426749/

Chronic Fatigue Syndrome (Myalgic Encephalomyelitis) https://emedicine.medscape.com/article/235980-overview

Excitotoxicity: Still Hammering the Ischemic Brain in 2020 https://pubmed.ncbi.nlm.nih.gov/33192266/

Clinical Manifestations and Pathogenesis of Acute Necrotizing Encephalopathy: The Interface Between Systemic Infection and Neurologic Injury https://pubmed.ncbi.nlm.nih.gov/35058867/

Acute Disseminated Encephalomyelitis https://www.ncbi.nlm.nih.gov/books/NBK430934/

Mild Encephalopathy With Reversible Splenial Lesion: Description of Nine Cases and Review of the Literature https://pubmed.ncbi.nlm.nih.gov/33839562/

Respiratory Syncytial Virus Infects Peripheral and Spinal Nerves and Induces Chemokine-Mediated Neuropathy https://pubmed.ncbi.nlm.nih.gov/38135285/

Selective Serotonin Reuptake Inhibitors https://www.ncbi.nlm.nih.gov/books/NBK554406/

Join Drs Forest Arnold and Lin Chen as they discuss RSV and traveler health.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/998279). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Respiratory Syncytial Virus Is the Leading Cause of United States Infant Hospitalizations, 2009-2019: A Study of the National (Nationwide) Inpatient Sample https://pubmed.ncbi.nlm.nih.gov/35968878/

Mortality Associated With Influenza and Respiratory Syncytial Virus in the US, 1999-2018 https://pubmed.ncbi.nlm.nih.gov/35226079/

Estimated Incidence of Respiratory Hospitalizations Attributable to RSV Infections Across Age and Socioeconomic Groups https://pubmed.ncbi.nlm.nih.gov/36280891/

The Annual Economic Burden of Respiratory Syncytial Virus in Adults in the United States https://pubmed.ncbi.nlm.nih.gov/38060972/

Almost 200 People Reported COVID-19 After Attending CDC Conference https://www.idse.net/Covid-19/Article/05-23/COVID-COVID-19-CDC-Conference-Outbreak/70425

CDC Traveler's Health Branch https://www.cdc.gov/ncezid/dgmq/focus-areas/travelers-health.html

Traveler-Based Genomic Surveillance for Early Detection of New SARS-CoV-2 Variants https://wwwnc.cdc.gov/travel/page/travel-genomic-surveillance

CDC Expands Testing of International Air Traveler Samples to Include Flu, RSV, and Other Respiratory Viruses https://www.cdc.gov/media/releases/2023/s1107-testing-respiratory-viruses.html

GeoSentinel https://geosentinel.org/

Travellers and Influenza: Risks and Prevention https://pubmed.ncbi.nlm.nih.gov/28077609/

Join Drs Forest Arnold and Edward Walsh as they discuss risk factors and complications of RSV in adults.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/998278). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

RSV Surveillance & Research https://www.cdc.gov/rsv/research/index.html

Respiratory Viral Infections in the Elderly https://pubmed.ncbi.nlm.nih.gov/33749408/

Structure and Function of Respiratory Syncytial Virus Surface Glycoproteins https://pubmed.ncbi.nlm.nih.gov/24362685/

Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus https://pubmed.ncbi.nlm.nih.gov/24179220/

Respiratory Syncytial Virus Vaccines: A Review of the Candidates and the Approved Vaccines https://pubmed.ncbi.nlm.nih.gov/37887775/

Efficacy and Safety of a Bivalent RSV Prefusion F Vaccine in Older Adults https://pubmed.ncbi.nlm.nih.gov/37018468/

Efficacy and Safety of an mRNA-Based RSV PreF Vaccine in Older Adults https://pubmed.ncbi.nlm.nih.gov/38091530/

Respiratory Syncytial Virus Prefusion F Protein Vaccine in Older Adults https://pubmed.ncbi.nlm.nih.gov/36791160/

Vaccine Adverse Event Reporting System https://vaers.hhs.gov/reportevent.html

RSV ACIP Vaccine Recommendations https://www.cdc.gov/vaccines/hcp/acip-recs/vacc-specific/rsv.html

Rates of RSV are rising in rural communities. How are rural healthcare providers responding? Join Drs Forest Arnold and Brittanie West as they discuss.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/985982). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Respiratory Syncytial Virus Infection https://emedicine.medscape.com/article/971488-overview

Hemoglobin A1c Testing https://emedicine.medscape.com/article/2049478-overview

The Utility of Point of Care Ultrasonography (POCUS) https://pubmed.ncbi.nlm.nih.gov/34840746/

Bedside Lung Ultrasound in Emergency Protocol as a Diagnostic Tool in Patients of Acute Respiratory Distress Presenting to Emergency Department https://pubmed.ncbi.nlm.nih.gov/29937643/

Noncardiogenic Pulmonary Edema Imaging https://emedicine.medscape.com/article/360932-overview

Procalcitonin (PCT) https://emedicine.medscape.com/article/2096589-overview

RSV-associated Hospitalization Surveillance Network https://www.cdc.gov/rsv/research/rsv-net/dashboard.html

Evaluation of the Alinity m Resp-4-Plex Assay for the Detection of Severe Acute Respiratory Syndrome Coronavirus 2, Influenza A Virus, Influenza B Virus, and Respiratory Syncytial Virus https://pubmed.ncbi.nlm.nih.gov/35107357/

State-level Estimates of COPD https://www.cdc.gov/copd/data-and-statistics/state-estimates.html

ACIP Recommendations https://www.cdc.gov/vaccines/acip/recommendations.html

CDC Recommends a Powerful New Tool to Protect Infants From the Leading Cause of Hospitalization https://www.cdc.gov/media/releases/2023/p-0803-new-tool-prevent-infant-hospitalization-.html

Evidence to Recommendations for Nirsevimab https://www.cdc.gov/vaccines/acip/meetings/downloads/slides-2023-02/slides-02-23/rsv-pediatric-04-jones-508.pdf

Dr Barney Graham, Time's 2021 Hero of the Year for his work on the COVID-19 vaccine, joins Dr Forest Arnold in this episode covering the groundbreaking work done to develop an RSV vaccine.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/985981). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Respiratory Syncytial Virus Infection https://emedicine.medscape.com/article/971488-overview

Field Evaluation of a Respiratory Syncytial Virus Vaccine and a Trivalent Parainfluenza Virus Vaccine in a Pediatric Population https://pubmed.ncbi.nlm.nih.gov/4305200/

Structure and Function of Respiratory Syncytial Virus Surface Glycoproteins https://pubmed.ncbi.nlm.nih.gov/24362685/

Identification and Characteristics of Fusion Peptides Derived From Enveloped Viruses https://pubmed.ncbi.nlm.nih.gov/34497798/

Brief History and Characterization of Enhanced Respiratory Syncytial Virus Disease https://pubmed.ncbi.nlm.nih.gov/26677198/

Structure-based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus https://pubmed.ncbi.nlm.nih.gov/24179220/

FDA Approves First Respiratory Syncytial Virus (RSV) Vaccine https://www.fda.gov/news-events/press-announcements/fda-approves-first-respiratory-syncytial-virus-rsv-vaccine

Vaccine-associated Enhanced Disease: Case Definition and Guidelines for Data Collection, Analysis, and Presentation of Immunization Safety Data https://pubmed.ncbi.nlm.nih.gov/33637387/

Th1 and Th2 Responses: What Are They? https://pubmed.ncbi.nlm.nih.gov/10938051/

Cytokine Pathways in Allergic Disease https://pubmed.ncbi.nlm.nih.gov/22301949/

Treatment therapies for adults with RSV have been elusive, but there are promising breakthroughs on the horizon. Join Drs Forest Arnold and Richard Plemper as they discuss.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/985980). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Cell Entry of Enveloped Viruses https://pubmed.ncbi.nlm.nih.gov/21927634/

Product Review on the Monoclonal Antibody Palivizumab for Prevention of Respiratory Syncytial Virus Infection https://pubmed.ncbi.nlm.nih.gov/28605249/

Palivizumab for Preventing Severe Respiratory Syncytial Virus (RSV) Infection in Children https://pubmed.ncbi.nlm.nih.gov/34783356/

Nirsevimab: A Promising Therapy for RSV https://pubmed.ncbi.nlm.nih.gov/35544094/

Nirsevimab for Prevention of RSV in Healthy Late-preterm and Term Infants https://pubmed.ncbi.nlm.nih.gov/35235726/

Oral GS-5806 Activity in a Respiratory Syncytial Virus Challenge Study https://pubmed.ncbi.nlm.nih.gov/25140957/

A Phase 2b, Randomized, Double-blind, Placebo-controlled Multicenter Study Evaluating Antiviral Effects, Pharmacokinetics, Safety, and Tolerability of Presatovir in Hematopoietic Cell Transplant Recipients With Respiratory Syncytial Virus Infection of the Lower Respiratory Tract https://pubmed.ncbi.nlm.nih.gov/31915807/

Ark Biopharmaceutical Presents Positive Results in Phase 3 AIRFLO Study of Ziresovir in RSV-infected Hospitalized Infants at 12th International RSV Symposium https://www.globenewswire.com/en/news-release/2022/10/07/2530040/0/en/Ark-Biopharmaceutical-Presents-Positive-Results-in-Phase-3-AIRFLO-Study-of-Ziresovir-in-RSV-Infected-Hospitalized-Infants-at-12th-International-RSV-Symposium.html

Structural Insight Into Paramyxovirus and Pneumovirus Entry Inhibition https://pubmed.ncbi.nlm.nih.gov/32245118/

Molnupiravir for Treatment of COVID-19 https://pubmed.ncbi.nlm.nih.gov/35134041/

NIH COVID-19 Treatment Guidelines—Molnupiravir https://www.covid19treatmentguidelines.nih.gov/therapies/antivirals-including-antibody-products/molnupiravir/

Quantitative Efficacy Paradigms of the Influenza Clinical Drug Candidate EIDD-2801 in the Ferret Model https://pubmed.ncbi.nlm.nih.gov/31945316/

Compound Summary Molnupiravir https://pubchem.ncbi.nlm.nih.gov/compound/Molnupiravir

RSV infection before or after bone marrow transplantation or CAR T-cell therapy can be challenging to manage. Tune in to hear experts Drs Forest Arnold and Melody Smith discuss.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/985979). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Respiratory Syncytial Virus Infection https://emedicine.medscape.com/article/971488-overview

Hematopoietic Stem Cell Transplantation (HSCT) https://emedicine.medscape.com/article/208954-overview

Cancer Immunotherapy With Chimeric Antigen Receptor (CAR) T Cells https://emedicine.medscape.com/article/2500108-overview

Respiratory Syncytial Virus Hospitalization Surveillance Network (RSV-NET) https://www.cdc.gov/rsv/research/rsv-net/index.html

Diagnosis of Respiratory Syncytial Virus Infection: Comparison of Reverse Transcription-PCR to Viral Culture and Serology in Adults With Respiratory Illness https://pubmed.ncbi.nlm.nih.gov/11880399/

Conditioning Regimen https://www.cancer.gov/publications/dictionaries/cancer-terms/def/conditioning-regimen

Ribavirin (Rx) https://reference.medscape.com/drug/rebetol-ribasphere-ribavirin-342625

FDA Approves First Respiratory Syncytial Virus (RSV) Vaccine https://www.fda.gov/news-events/press-announcements/fda-approves-first-respiratory-syncytial-virus-rsv-vaccine

Graft Versus Host Disease (GVHD) https://emedicine.medscape.com/article/429037-overview

Infections After Hematopoietic Stem Cell Transplantation https://emedicine.medscape.com/article/1013470-overview#a5