Intermittent energy restriction (IER) and periodic fasting (PF) has become a popular dietary trend and topic of research for metabolic outcomes and weight loss. This episode, editor-in-chief Dr. Douglas Taren speaks with featured article authors Elske van den Burg and Marjolein Schoonakker on their systematic review summarizing current knowledge of the effects of IER and PF in patients with T2D on markers of metabolic control and the need for glucose-lowering medication.