Glioblastoma multiforme (GBM) remains one of the deadliest brain cancers, with survival measured in months despite surgery, radiation, and chemotherapy. But what if the key isn’t just in attacking tumor cells directly, but in reshaping their fuel supply?

In this episode of The Health Pulse, we uncover the fascinating science showing how GBM cells depend almost exclusively on glucose and glutamine for survival. Unlike healthy brain tissue, these cancer cells struggle to adapt when forced to use ketone bodies as fuel—a weakness that can potentially be exploited.

We explore how ketogenic diets, fasting, caloric restriction, and metabolic-targeted compounds may tilt the terrain against cancer, making tumors more vulnerable to conventional therapies while protecting healthy tissue. With promising results in animal studies and encouraging signs in early human trials, this metabolic strategy represents a paradigm shift in cancer treatment.

While more research is needed, this episode offers hopeful insights into how altering the metabolic environment may open new therapeutic possibilities for GBM patients.

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