VJHemOnc Podcast

Today’s podcast focuses on the role of BTK inhibitors (BTKis) in the treatment of mantle cell lymphoma (MCL). You will hear from experts Krish Patel, MD, Providence Swedish Cancer Institute, Seattle, WA, Marek Trněný, MD, PhD, Charles University Hospital, Prague, Czech Republic, Michael Wang, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, and Craig Portell, MD, University of Virginia, Charlottesville, VA. They share updates on trials investigating BTKis in the frontline treatment of MCL, including the ECHO (NCT02972840), SHINE (NCT01776840), and TRIANGLE (NCT02858258) studies. They then go on to discuss how these agents are optimally sequenced and give advice for managing cardiac toxicities associated with BTKis.  

The post Exploring the role of BTK inhibitors in mantle cell lymphoma: sequencing & managing adverse events appeared first on VJHemOnc.

Menin inhibitors are emerging as a promising therapeutic approach in acute myeloid leukemia (AML), particularly in patients with specific genetic mutations such as KMT2A-rearranged and NPM1-mutated AML. These inhibitors disrupt the leukemogenic signaling pathways that drive leukemia cell proliferation by blocking the actions of menin. They can help restore regular gene expression and halt the progression of AML.

In this podcast episode, you will hear updates on menin inhibitors in AML from the 6th International Workshop on Acute Leukemias (iwAL), which took place in Phoenix, AZ. Experts Joshua Zeidner, MD, UNC Lineberger Comprehensive Cancer Center, Chapel Hill, NC, and Eunice Wang, MD, Roswell Park Comprehensive Cancer Center, Buffalo, NY, delve into current data on the four menin inhibitors being investigated in AML. They then go on to discuss the development of resistance to this drug class and the potential value of these agents in the post-transplant setting

The post An update on menin inhibition in AML from iwAL 2024: current data, mechanisms of resistance, & more! appeared first on VJHemOnc.

Today’s podcast features discussions from the 21st International Workshop on Non-Hodgkin Lymphoma (iwNHL) which took place in Nice, France. You will hear updates on the use of CAR T-cell therapy in non-Hodgkin lymphoma (NHL) from experts Catherine Bollard, MBChB, MD, FRACP, FRCPA, Children’s National Health System, Washington, DC, Stephen Schuster, MD, University of Pennsylvania, Philadelphia, PA, and Jason Westin, MD, FACP, The University of Texas MD Anderson Cancer Center, Houston, TX. They discuss where CAR-T fits into the treatment landscape, managing toxicities, and the potential of allogeneic CAR-T products.

You will also hear from Stephen Ansell, MD, PhD, Mayo Clinic, Rochester, MN, Marion Subklewe, MD, Ludwig-Maximilians-University of Munich, Munich, Germany, Martin Hutchings, MD, PhD, Copenhagen University Hospital, Copenhagen, Denmark, and Krish Patel, MD, Swedish Cancer Institute, Seattle, WA, who share insights into the use of bispecific antibodies in the treatment of NHL. Their discussion focuses on comparisons between CAR-T and bispecifics and the unique challenges of using bispecific antibodies, including mitigating toxicities. They also mention exciting combination approaches with antibody-drug conjugates and co-stimulatory agents.

The post CAR T-cells and bispecific antibodies in the treatment of NHL: updates from iwNHL 2024 appeared first on VJHemOnc.

Today’s podcast features a discussion with leading experts Harry Erba, MD, PhD, Duke University, Durham, NC, Farhad Ravandi, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, and Thomas Cluzeau, MD, PhD, Central University Hospital of Nice, Nice, France, on strategies to prolong remission in acute myeloid leukemia (AML). They focus on the roles of intensive chemotherapy, allogeneic stem cell transplantation, and maintenance therapies. Key topics include optimizing initial therapy to achieve deeper remissions, the benefits of using measurable residual disease (MRD) assays to tailor post-remission treatments, and exploring new maintenance options such as targeted agents.

The post Prolonging remission in AML: current approaches & future outlooks appeared first on VJHemOnc.

Welcome to the final episode of VJHemOnc’s Blood Cancer Awareness Month special series!

This episode focuses on the role of artificial intelligence (AI) in personalizing blood cancer care. Carsten Niemann, MD, PhD, Copenhagen University Hospital, Copenhagen, Denmark, discusses the value of AI in hematological oncology and how it is currently used in the clinic. He then shares details of a treatment infection model for chronic lymphocytic leukemia (CLL) that has been deployed in his institution. Gareth Morgan, MD, PhD, FRCP, FRCPath, NYU Langone, New York City, NY, delves into the role of AI in the classification of multiple myeloma and the prediction of patients who will need transplantation. He also touches on the use of AI to better understand genomic data.

References

Niemann C, Levin M-D, Österborg A, et al. The CLL Treatment Infection Model – Clinical Prospective Validation as Part of the Prevent-Acall Trial. Hemasphere. 2023;7(Suppl):e1432517.

The post A focus on the use of artificial intelligence to personalize blood cancer care appeared first on VJHemOnc.

Welcome to the third episode of VJHemOnc’s Blood Cancer Awareness Month special series! 

The focus of this episode is pediatric acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). You will hear from Michele Redell, MD, Texas Children’s Cancer Center, Baylor College of Medicine, Houston, TX, who shares insights into the Pediatric Acute Leukemia (PedAL) Screening Trial and challenges that remain in the treatment of AML. Mark Litzow, MD, Mayo Clinic, Rochester, MN, discusses a study investigating drug responses in children compared to adults. Finally, Christina Peters, MD, St. Anna Children’s Hospital, Vienna, Austria, speaks on the FORUM trial (NCT01949129) and CAR-T therapy for pediatric patients. 

The post A focus on pediatric leukemias: trials, treatments, & challenges appeared first on VJHemOnc.

Welcome to the second episode of VJHemOnc’s Blood Cancer Awareness Month special series! 

Today’s episode focuses on the psychosocial impacts of living with blood cancer. First, you will hear from Lorna Warwick, BA, Lymphoma Coalition, Toronto, Canada, who shares the work of the Lymphoma Coalition Global Patient Survey. Next, you will hear insights from Surabhi Chaturvedi, MBACP, King’s College Hospital NHS Foundation Trust, London, UK, who is a senior psychotherapist in hematological oncology. Finally, Charlie Craddock, CBE, FRCP, FRCPath, University of Birmingham, Birmingham, UK, will discuss the psychosocial impacts of transplantation in acute myeloid leukemia (AML). 

The post A focus on the psychosocial impacts of living with blood cancer appeared first on VJHemOnc.

Welcome to the first episode of VJHemOnc’s Blood Cancer Awareness Month special series! 

This episode focuses on global perspectives of blood cancers and addresses the disparities that exist in awareness, diagnosis, and treatment. First, Lalit Kumar, MD, MBBS, Artemis Hospital, New Delhi, India, discusses challenges that exist in the management of blood cancers in India, and programs that are in place to address these. Joseph Mikhael, MD, MEd, FRCPC, FACP, Translational Genomics Research Institute (TGen), Phoenix, AZ, then goes on to address racial disparities in the treatment of multiple myeloma in America. Amrutha Sridhar, MBBS, University College London Hospitals, London, UK, discusses socioeconomic and racial disparities in myeloma trial recruitment, followed by Brian Koffman, MDCM (retired), MS Ed, CLL Society, Inc., Chula Vista, CA, who shares insights into a survey investigating global disparities in access to treatment and resources for patients with chronic lymphocytic leukemia in low-income countries.

The post Global perspectives on blood cancers: addressing disparities in awareness, diagnosis, and treatment appeared first on VJHemOnc.

Polycythemia vera (PV) and essential thrombocythemia (ET) are myeloproliferative neoplasms (MPNs) characterized by the overproduction of red blood cells and platelets, respectively, due to mutations in hematopoietic stem cells.

This podcast features a discussion from the 2nd International Workshop on Myelodysplastic Syndromes & Myeloproliferative Neoplasms (iwMDS/iwMPNs). Experts Andrew Kuykendall, MD, Moffitt Cancer Center, Tampa, FL; Lucia Masarova, MD, The University of Texas MD Anderson Cancer Center, Houston, TX; and Kristen Pettit, MD, University of Michigan, Ann Arbor, MI, share insights into the management of PV and ET. They focus on treating the adolescent and young adult (AYA) population, defining goals when treating patients, and the feasibility of assessing long-term outcomes in clinical trials. Additionally, they emphasize collaborative research approaches and explore the potential for early interventions at the stage of clonal hematopoiesis in AYA patients.

The post Insights into PV and ET: treating the AYA population, defining goals when treating patients, & more appeared first on VJHemOnc.

This week’s VJHemOnc podcast brings you updates in hemophilia from the 32nd Congress of the International Society on Thrombosis and Haemostasis (ISTH), held in Bangkok, Thailand, and virtually.

You hear from experts Omolade Awodu, MBChB, MD, FMCPath, University of Benin, Benin City, Nigeria, who discusses key hemophilia clinical trials in 2024, Radek Kaczmarek, PhD, Indiana University School of Medicine, Indianapolis, IN, who gives an overview of gene therapies for hemophilia, and Matteo Luciani, MD, Bambino Gesù Children’s Hospital, Rome, Italy, who shares insights into the remaining challenges for patients with hemophilia.

The post Hemophilia updates from ISTH 2024: ongoing clinical trials, emerging gene therapies & remaining challenges appeared first on VJHemOnc.